RAET1E - retinoic acid early transcript 1E Gene

中文名称：视黄酸早期转录物 1E

种属: Homo sapiens

同用名: RL-4; LETAL; ULBP4; N2DL-4; NKG2DL4; RAET1E2; bA350J20.7

关于 RAET1E

功能概要

该基因属于 RAET1 家族，由主要组织相容性复合体 (MHC) I 类相关基因组成，位于染色体 6q24.2-q25.3 的簇中。该蛋白和 RAET1G 蛋白与其他 RAET1 蛋白的不同之处在于，它们在 C 末端具有 I 型跨膜序列，而不是糖基磷脂酰肌醇锚定序列。该蛋白作为 NKG2D 受体的配体发挥作用，该受体在多种类型的免疫细胞表面表达，并参与先天性和适应性免疫反应。已发现该基因编码不同亚型的可变剪接转录本变体。[RefSeq 提供，2011 年 8 月]

This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]