2. Gene
  3. Dvl1 - dishevelled segment polarity protein 1 Gene

Dvl1 - dishevelled segment polarity protein 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Dvl; mKIAA4029

基因 ID: 13542 | 基因类型: protein coding

关于 Dvl1

功能概要

The protein encoded by this gene is a member of the Dishevelled family of proteins. These proteins have an N-terminal Dishevelled/Axin domain, a Dishevelled, EGL-10, Plextrin domain, a central PDZ domain, and a C-terminal domain of approximately 200 Amino acids. They regulate both canonical and non-canonical Wnt signaling as well as planar cell polarity pathways. Mice deficient for this gene are viable and fertile but display reduced social interaction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Dvl1 基因产物(2)

mRNA Protein Name
NM_001356381.1 NP_001343310.1 segment polarity protein dishevelled homolog DVL-1 isoform 2
NM_010091.5 NP_034221.3 segment polarity protein dishevelled homolog DVL-1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables beta-catenin binding IDA
IDA: 通过直接分析推断
21880741 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11113207 MGI
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
22899650 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway IDA
IDA: 通过直接分析推断
14966280 MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway IGI
IGI: 通过遗传相互作用推断
14966280 MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway IMP
IMP: 通过突变表型推断
16116426 MGI
acts upstream of or within axon extension IDA
IDA: 通过直接分析推断
18716223 MGI
acts upstream of or within axon guidance IDA
IDA: 通过直接分析推断
18716223 MGI
acts upstream of or within axonogenesis IDA
IDA: 通过直接分析推断
14734535 MGI
involved in canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
14648878 MGI
involved in canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
10409711 MGI
involved in canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
11742004 MGI
acts upstream of or within cochlea morphogenesis IGI
IGI: 通过遗传相互作用推断
16116426 MGI
acts upstream of or within collateral sprouting IDA
IDA: 通过直接分析推断
18716223 MGI
acts upstream of or within convergent extension involved in neural plate elongation IGI
IGI: 通过遗传相互作用推断
16571627 MGI
acts upstream of or within convergent extension involved in organogenesis IGI
IGI: 通过遗传相互作用推断
16116426 MGI
acts upstream of or within convergent extension involved in organogenesis IMP
IMP: 通过突变表型推断
16116426 MGI
acts upstream of or within cytoplasmic microtubule organization IDA
IDA: 通过直接分析推断
14648878 MGI
acts upstream of or within cytoplasmic microtubule organization IGI
IGI: 通过遗传相互作用推断
14648878 MGI
acts upstream of or within dendrite morphogenesis IMP
IMP: 通过突变表型推断
15608632 MGI
involved in heart looping IGI
IGI: 通过遗传相互作用推断
22841628 MGI
acts upstream of or within negative regulation of protein phosphorylation IGI
IGI: 通过遗传相互作用推断
9271238 MGI
acts upstream of or within neuromuscular junction development IGI
IGI: 通过遗传相互作用推断
12165471 MGI
acts upstream of or within neurotransmitter secretion IGI
IGI: 通过遗传相互作用推断
16818724 MGI
involved in outflow tract morphogenesis IGI
IGI: 通过遗传相互作用推断
22841628 MGI
acts upstream of or within positive regulation of neuron projection development IMP
IMP: 通过突变表型推断
15548427 MGI
acts upstream of or within positive regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
24305805 MGI
involved in postsynapse organization IDA
IDA: 通过直接分析推断
21670302 MGI
involved in postsynapse organization IMP
IMP: 通过突变表型推断
21670302 MGI
acts upstream of or within prepulse inhibition IMP
IMP: 通过突变表型推断
9298901 MGI
involved in presynapse assembly IDA
IDA: 通过直接分析推断
16818724 MGI
involved in presynapse assembly IMP
IMP: 通过突变表型推断
16818724 MGI
acts upstream of or within protein localization to microtubule IGI
IGI: 通过遗传相互作用推断
18716223 MGI
involved in protein stabilization IGI
IGI: 通过遗传相互作用推断
26359454 MGI
acts upstream of or within receptor clustering IGI
IGI: 通过遗传相互作用推断
12165471 MGI
involved in regulation of postsynapse organization IDA
IDA: 通过直接分析推断
23826333 MGI
involved in regulation of postsynapse organization IMP
IMP: 通过突变表型推断
23826333 MGI
acts upstream of or within regulation of protein phosphorylation IGI
IGI: 通过遗传相互作用推断
14734535 MGI
involved in regulation of synaptic vesicle exocytosis IDA
IDA: 通过直接分析推断
26400647 MGI
involved in regulation of synaptic vesicle exocytosis IMP
IMP: 通过突变表型推断
26400647 MGI
acts upstream of or within skeletal muscle acetylcholine-gated channel clustering IMP
IMP: 通过突变表型推断
19020093 MGI
acts upstream of or within social behavior IMP
IMP: 通过突变表型推断
9298901 MGI
acts upstream of or within synapse organization IGI
IGI: 通过遗传相互作用推断
16818724 MGI
acts upstream of or within synapse organization IMP
IMP: 通过突变表型推断
16818724 MGI
acts upstream of positive effect synaptic vesicle exocytosis IMP
IMP: 通过突变表型推断
16818724 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
26400647 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: 通过突变表型推断
26400647 MGI
part of Wnt signalosome IDA
IDA: 通过直接分析推断
22899650 MGI
located in axon IDA
IDA: 通过直接分析推断
14734535 MGI
located in clathrin-coated vesicle IDA
IDA: 通过直接分析推断
17005174 MGI
colocalizes with cytoplasm IDA
IDA: 通过直接分析推断
12138115 MGI
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
11113207 MGI
is active in cytosol IDA
IDA: 通过直接分析推断
21189423 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
21670302 MGI
is active in glutamatergic synapse IEP
IEP: 通过表达模式推断
21670302 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
21670302 MGI
located in microtubule cytoskeleton IDA
IDA: 通过直接分析推断
14734535 MGI
is active in neuronal dense core vesicle EXP
EXP: 通过实验结果推断
21321602 MGI
is active in neuronal dense core vesicle IDA
IDA: 通过直接分析推断
21321602 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
12138115 MGI
is active in postsynaptic density IDA
IDA: 通过直接分析推断
21670302 MGI
is active in postsynaptic density IEP
IEP: 通过表达模式推断
21670302 MGI
is active in presynapse IDA
IDA: 通过直接分析推断
16818724 MGI
is active in presynapse IMP
IMP: 通过突变表型推断
16818724 MGI
located in synapse IDA
IDA: 通过直接分析推断
16818724 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

segment polarity protein dishevelled homolog DVL-1

DSH homolog 1

dishevelled, dsh homolog 1

dishevelled-1

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04076 DVL1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20720 Dvl1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27232 Dvl1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dvl1 NCBI NCBI:1855
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