NEK7 - NIMA related kinase 7 Gene

中文名称：NIMA 相关激酶 7

种属: Homo sapiens

基因 ID: 140609 | 基因类型: protein coding

关于 NEK7

Cytogenetic location: 1q31.3 Genomic coordinates (GRCh38): 1:198,156,998-198,322,420 (from NCBI)

This gene has 8 transcripts (splice variants), 209 orthologues and 8 paralogues. Ubiquitous expression in heart (RPKM 38.5), fat (RPKM 31.8) and 24 other tissues.

功能概要

NIMA 相关激酶与 Aspergillus nidulans ‘never in Mitosis A’ 基因的基因产物具有高度氨基酸序列同一性，该基因控制有丝分裂的启动。[OMIM 提供，2002 年 7 月]

NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in Mitosis A' gene, which controls initiation of Mitosis.[supplied by OMIM, Jul 2002]

NEK7 基因产物(1)

mRNA	Protein	Name
NM_133494.3	NP_598001.1	serine/threonine-protein kinase Nek7

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables molecular function activator activity	IDA IDA: 通过直接分析推断	19941817	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	26188091	GOA
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	19941817	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of NLRP3 inflammasome complex assembly	IDA IDA: 通过直接分析推断	31189953	GOA
acts upstream of or within positive regulation of telomere maintenance	IMP IMP: 通过突变表型推断	21531765	GOA
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	12840024	GOA
involved in regulation of mitotic cell cycle	IDA IDA: 通过直接分析推断	19941817	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in microtubule organizing center	IDA IDA: 通过直接分析推断	17586473	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NEK7 蛋白结构

Pkinase

0
100
200
302 a.a.

蛋白主名

其他名称

serine/threonine-protein kinase Nek7

NIMA (never in mitosis gene a)-related kinase 7

NEK7 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NEK7	Q8TDX7	HUWE1	Homo sapiens	Q7Z6Z7-2	Y2H Pooling	32814053
种属内	NEK7	Q8TDX7	HUWE1	Homo sapiens	Q7Z6Z7-2	Validated Y2H	32814053
种属内	NEK7	Q8TDX7	HUWE1	Homo sapiens	Q7Z6Z7-2	Y2H Array	32814053
种属内	NEK7	Q8TDX7	USP12	Homo sapiens	O75317	Y2H Pooling	32814053
种属内	NEK7	Q8TDX7	USP12	Homo sapiens	O75317	Validated Y2H	32814053
种属内	NEK7	Q8TDX7	USP12	Homo sapiens	O75317	Y2H Array	32814053
种属内	NEK7	Q8TDX7	ISY1	Homo sapiens	Q9ULR0	Validated Y2H	32814053
种属内	NEK7	Q8TDX7	ISY1	Homo sapiens	Q9ULR0	Y2H Array	32814053
种属内	NEK7	Q8TDX7	ISY1	Homo sapiens	Q9ULR0	Y2H Pooling	32814053
种属内	NEK7	Q8TDX7	MGC39372	Homo sapiens	Q8TB02	Validated Y2H	32814053
种属内	NEK7	Q8TDX7	MGC39372	Homo sapiens	Q8TB02	Y2H Array	32814053
种属内	NEK7	Q8TDX7	MGC39372	Homo sapiens	Q8TB02	Y2H Pooling	32814053
种属内	NEK7	Q8TDX7	TMPO	Homo sapiens	P42166	Pull Down	32707033
种属内	NEK7	Q8TDX7	PGK1	Homo sapiens	P00558	Pull Down	32707033
种属内	NEK7	Q8TDX7	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
种属内	NEK7	Q8TDX7	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
种属内	NEK7	Q8TDX7	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 NEK7 蛋白

目录号	产品名	蛋白编号	纯度
HY-P75935	NEK7 Protein, Human (sf9, His-GST)	Q8TDX7-1 (M1-S302)	≥95%

NEK7 抗体

目录号	产品名	应用	反应物种
HY-P81615	NEK7 Antibody (YA1360)	WB, IP	Mouse, Rat

关联疾病

疾病名称

别名

Muckle-Wells Syndrome

MWS	Urticaria-Deafness-Amyloidosis Syndrome
Uda Syndrome	Neutrophilic Urticaria
Urticaria, Deafness And Amyloidosis	Cryopyrin-Associated Periodic Syndrome 2
Caps2	Muckle Wells Syndrome
Urticaria-Deafness-Amyloidosis	Cryopyrin-Associated Periodic Syndromes

Cinca Syndrome

CINCA	Nomid
Cryopyrin-Associated Periodic Syndrome 3	Chronic Neurologic Cutaneous And Articular Syndrome
Multisystem Inflammatory Disease, Neonatal-Onset	Caps3
Chronic Infantile Neurological Cutaneous Articular Syndrome	Infantile-Onset Multisystem Inflammatory Disease
Iomid Syndrome	Neonatal-Onset Multisystem Inflammatory Disease
Nomid Syndrome	Prieur-Griscelli Syndrome
Neonatal Onset Multisystem Inflammatory Disease	Chronic Infantile Neurological, Cutaneous And Articular Syndrome
Iomid	Infantile Onset Multisystem Inflammatory Disease
Prieur Griscelli Syndrome	Chronic Infantile Neurological Cutaneous And Articular Syndrome
Chronic, Infantile, Neurological, Cutaneous, Articular Syndrome	Chronic Infantile Neurologic Cutaneous And Articular Syndrome
Chronic Infantile Neurological, Cutaneous, And Articular Syndrome	Cryopyrin-Associated Periodic Syndromes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-172162	LC-04-045	Degrader	99.56%	否
HY-163358	SLC3037	Inhibitor	99.85%	否
HY-175452	MRT-3486	Degrader	/	否
HY-174270	NLRP3-IN-79	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	NEK7	VGNC	VGNC:107901
Rattus norvegicus	NEK7	RGD	RGD:1311160
Mus musculus	NEK7	MGD	MGI:1890645
Macaca mulatta	NEK7	VGNC	VGNC:81484
Bos taurus	NEK7	VGNC	VGNC:31998
Canis familiaris	NEK7	VGNC	VGNC:43734
Others	NEK7	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4