2. Gene
  3. Lpin1 - lipin 1 Gene

Lpin1 - lipin 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: fld; Lipin1

基因 ID: 14245 | 基因类型: protein coding

关于 Lpin1

功能概要

Enables several functions, including histone deacetylase binding activity; peroxisome proliferator activated receptor binding activity; and phosphatidate Phosphatase activity. Involved in several processes, including mitochondrial fission; positive regulation of cold-induced thermogenesis; and triglyceride mobilization. Acts upstream of or within several processes, including actin Cytoskeleton reorganization; positive regulation of histone deacetylation; and ruffle organization. Located in endoplasmic reticulum; mitochondrial outer membrane; and nuclear membrane. Part of transcription regulator complex. Is expressed in liver; nervous system; olfactory epithelium; and tooth. Used to study lipodystrophy. Orthologous to human LPIN1 (lipin 1). [provided by Alliance of Genome Resources, Apr 2022]

Lpin1 基因产物(4)

mRNA Protein Name
NM_001130412.1 NP_001123884.1 phosphatidate phosphatase LPIN1 isoform a
NM_001355598.1 NP_001342527.1 phosphatidate phosphatase LPIN1 isoform b
NM_015763.4 NP_056578.2 phosphatidate phosphatase LPIN1 isoform b
NM_172950.3 NP_766538.2 phosphatidate phosphatase LPIN1 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
IDA: 通过直接分析推断
20385772 MGI
enables histone deacetylase binding IDA
IDA: 通过直接分析推断
20385772 MGI
enables peroxisome proliferator activated receptor binding IPI
IPI: 通过物理相互作用推断
16950137 MGI
enables phosphatidate phosphatase activity IDA
IDA: 通过直接分析推断
17158099 MGI
enables phosphatidate phosphatase activity IGI
IGI: 通过遗传相互作用推断
24133206 MGI
enables phosphatidate phosphatase activity IMP
IMP: 通过突变表型推断
24133206 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16950137 MGI
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
16950137 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within actin cytoskeleton organization IMP
IMP: 通过突变表型推断
10438476 MGI
acts upstream of or within cellular lipid metabolic process IMP
IMP: 通过突变表型推断
22337502 MGI
acts upstream of or within cellular response to insulin stimulus IMP
IMP: 通过突变表型推断
10438476 MGI
involved in fatty acid catabolic process IDA
IDA: 通过直接分析推断
16950137 MGI
acts upstream of or within immune response IMP
IMP: 通过突变表型推断
22337502 MGI
acts upstream of or within lipid metabolic process IMP
IMP: 通过突变表型推断
2722772 MGI
involved in mitochondrial fission IDA
IDA: 通过直接分析推断
21397848 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
20385772 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: 通过突变表型推断
23028044 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16950137 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
20385772 MGI
acts upstream of or within regulation of fat cell differentiation IMP
IMP: 通过突变表型推断
11138012 MGI
acts upstream of or within ruffle organization IMP
IMP: 通过突变表型推断
10438476 MGI
involved in triglyceride biosynthetic process IMP
IMP: 通过突变表型推断
24133206 MGI
involved in triglyceride mobilization IDA
IDA: 通过直接分析推断
16950137 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
19753306 MGI
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
26475860 MGI
is active in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
17105729 MGI
located in mitochondrial outer membrane IDA
IDA: 通过直接分析推断
21397848 MGI
located in nuclear membrane IDA
IDA: 通过直接分析推断
22134922 MGI
located in nucleus IDA
IDA: 通过直接分析推断
11138012 MGI
part of transcription regulator complex IDA
IDA: 通过直接分析推断
20385772 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

phosphatidate phosphatase LPIN1

fatty liver dystrophy protein

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07769 LPIN1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19455 Lpin1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25948 Lpin1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Lpin1 NCBI NCBI:23175
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