PARP4 - poly(ADP-ribose) polymerase family member 4 Gene

中文名称：聚 (ADP-核糖) 聚合酶家族成员 4

种属: Homo sapiens

同用名: PH5P; p193; ARTD4; PARPL; VPARP; VWA5C; PARP-4; VAULT3; ADPRTL1

关于 PARP4

功能概要

该基因编码聚 (ADP-核糖基) 转移酶样 1 蛋白，能够催化聚 (ADP-核糖基) 化反应。该蛋白质具有与聚 (ADP-核糖基) 转移酶同源的催化结构域，但缺少激活聚 (ADP-核糖基) 转移酶 C 末端催化结构域的 N 末端 DNA 结合结构域。由于该蛋白质不能直接结合 DNA，因此其转移酶活性可能会被其他因素激活，例如由广泛的羧基末端介导的蛋白质-蛋白质相互作用。[RefSeq 提供，2008 年 7 月]

This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008]