1. Gene
  2. Fzd4 - frizzled class receptor 4 Gene

Fzd4 - frizzled class receptor 4 Gene

种属: Mus musculus

同用名: Fz4

基因 ID: 14366 | 基因类型: protein coding

关于 Fzd4

功能概要

Enables Wnt-activated receptor activity; Wnt-protein binding activity; and cytokine binding activity. Involved in several processes, including cell surface receptor signaling pathway involved in cell-cell signaling; regulation of transcription, DNA-templated; and vasculature development. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; regulation of signal transduction; and vasculature development. Located in several cellular components, including cell-cell junction; dendrite; and glutamatergic synapse. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; nervous system; and sensory organ. Used to study Norrie disease and exudative vitreoretinopathy. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy 1. Orthologous to human FZD4 (Frizzled class receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Fzd4 基因产物(1)

mRNA Protein Name
NM_008055.4 NP_032081.3 frizzled-4 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Wnt receptor activity IPI
IPI: 通过物理相互作用推断
16163358 MGI
enables Wnt-protein binding IPI
IPI: 通过物理相互作用推断
12490564 MGI
enables cytokine binding IPI
IPI: 通过物理相互作用推断
15035989 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
15195140 MGI
enables signaling receptor activity IGI
IGI: 通过遗传相互作用推断
25424568 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Norrin signaling pathway IDA
IDA: 通过直接分析推断
15035989 MGI
involved in Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
25424568 MGI
acts upstream of or within angiogenesis IGI
IGI: 通过遗传相互作用推断
27823583 MGI
acts upstream of or within angiogenesis IMP
IMP: 通过突变表型推断
27823583 MGI
acts upstream of or within blood vessel development IMP
IMP: 通过突变表型推断
19837032 MGI
acts upstream of or within canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
16115200 MGI
involved in canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
19001373 MGI
acts upstream of or within cell population proliferation IMP
IMP: 通过突变表型推断
25414188 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: 通过表达模式推断
20439489 MGI
involved in cerebellum vasculature morphogenesis IMP
IMP: 通过突变表型推断
15035989 MGI
acts upstream of or within endothelial cell differentiation IMP
IMP: 通过突变表型推断
23217714 MGI
acts upstream of or within establishment of blood-brain barrier IGI
IGI: 通过遗传相互作用推断
30478038 MGI
acts upstream of or within establishment of blood-brain barrier IMP
IMP: 通过突变表型推断
23217714 MGI
involved in extracellular matrix-cell signaling IDA
IDA: 通过直接分析推断
15035989 MGI
acts upstream of or within locomotion involved in locomotory behavior IMP
IMP: 通过突变表型推断
11425903 MGI
acts upstream of or within luteinization IMP
IMP: 通过突变表型推断
16093361 MGI
involved in negative regulation of cell-substrate adhesion IMP
IMP: 通过突变表型推断
18156211 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
15035989 MGI
acts upstream of or within positive regulation of JUN kinase activity IGI
IGI: 通过遗传相互作用推断
15195140 MGI
involved in positive regulation of neuron projection arborization IGI
IGI: 通过遗传相互作用推断
25424568 MGI
acts upstream of or within progesterone secretion IMP
IMP: 通过突变表型推断
16093361 MGI
acts upstream of or within regulation of vascular endothelial growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
16093361 MGI
acts upstream of or within response to hypoxia IMP
IMP: 通过突变表型推断
25414188 MGI
acts upstream of or within retina vasculature development in camera-type eye IMP
IMP: 通过突变表型推断
23217714 MGI
acts upstream of or within retina vasculature morphogenesis in camera-type eye IGI
IGI: 通过遗传相互作用推断
19837032 MGI
acts upstream of or within retina vasculature morphogenesis in camera-type eye IMP
IMP: 通过突变表型推断
19837032 MGI
involved in retinal blood vessel morphogenesis IMP
IMP: 通过突变表型推断
15035989 MGI
acts upstream of or within sensory perception of sound IMP
IMP: 通过突变表型推断
11425903 MGI
acts upstream of or within substrate adhesion-dependent cell spreading IMP
IMP: 通过突变表型推断
18156211 MGI
acts upstream of or within vasculogenesis IMP
IMP: 通过突变表型推断
16093361 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell-cell junction IDA
IDA: 通过直接分析推断
15195140 MGI
located in dendrite IMP
IMP: 通过突变表型推断
25424568 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
16501258 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
15035989 MGI
located in plasma membrane IMP
IMP: 通过突变表型推断
18156211 MGI
is active in synapse IDA
IDA: 通过直接分析推断
16501258 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

frizzled-4

frizzled homolog 4

fz-4

mFz4

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Fzd4 NCBI NCBI:8322
Rattus norvegicus Fzd4 NCBI NCBI:64558