2. Gene
  3. SESN3 - sestrin 3 Gene

SESN3 - sestrin 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：sestrin 3

种属: Homo sapiens

同用名: SEST3

基因 ID: 143686 | 基因类型: protein coding

关于 SESN3

Cytogenetic location: 11q21 Genomic coordinates (GRCh38): 11:95,165,513-95,232,475 (from NCBI)

This gene has 6 transcripts (splice variants), 161 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 14.9), lymph node (RPKM 14.4) and 24 other tissues.

功能概要

该基因编码压力诱导蛋白 sestrin 家族的成员。编码的蛋白质降低了由 RAC-α 丝氨酸/苏氨酸蛋白激酶 (Akt) 和 FOXO 转录因子下游的活化 Ras 诱导的细胞内活性氧水平。该蛋白质是正常调节血糖、胰岛素抵抗所必需的，并在肥胖症的脂质储存中发挥作用。可变剪接导致多个转录本变体。[RefSeq 提供，2012 年 10 月]

This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular Reactive Oxygen Species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FOXO transcription factor. The protein is required for normal regulation of blood glucose, Insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

SESN3 基因产物(2)

mRNA Protein Name
NM_001271594.2 NP_001258523.1 sestrin-3 isoform 2
NM_144665.4 NP_653266.2 sestrin-3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25263562 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to amino acid starvation IMP
IMP: 通过突变表型推断
25263562 GOA
involved in cellular response to glucose starvation IMP
IMP: 通过突变表型推断
25263562 GOA
involved in negative regulation of TORC1 signaling IMP
IMP: 通过突变表型推断
25263562 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of GATOR2 complex IDA
IDA: 通过直接分析推断
25263562 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
25263562 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SESN3 蛋白结构

PA26

PA26: PA26 p53-induced protein (sestrin) (38 - 492)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 492 a.a.
蛋白主名 其他名称

sestrin-3

关联疾病

疾病名称 别名
Endometrial Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Endometrium

Adenosquamous Carcinoma Of The Endometrium

Endometrial Adenosquamous Cancer

Endometrial Adenosquamous Cell Carcinoma
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-175352 Nurr1 Agonist 14 / Phase 2
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12736 SESN3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21753 Sesn3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28271 Sesn3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus SESN3 VGNC VGNC:34490
Rattus norvegicus SESN3 RGD RGD:1309470
Macaca mulatta SESN3 VGNC VGNC:77291
Canis familiaris SESN3 VGNC VGNC:46049
Felis catus SESN3 VGNC VGNC:65036
Mus musculus SESN3 MGD MGI:1922997
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z