2. Vitamin D Related/Nuclear Receptor Immunology/Inflammation Apoptosis Neuronal Signaling Membrane Transporter/Ion Channel
  3. Nuclear Hormone Receptor 4A/NR4A SOD IAP Survivin Calcium Channel
  4. Nurr1 Agonist 14

Nurr1 Agonist 14 (Compound 32) 是一种 Nurr1 激动剂，其对 Nurr1 的 EC50 为 0.09 μM。Nurr1 Agonist 14 具有显著的神经保护活性，且不受残留 DHODH 抑制的影响。Nurr1 Agonist 14 可上调多巴胺能神经元中的神经保护基因，包括 SOD2、SESN3、BIRC5、XIAP、FLRT2 和 CRMP4。Nurr1 Agonist 14 可用于研究神经退行性疾病，例如阿尔茨海默病 (AD)、帕金森病 (PD) 和多发性硬化症 (MS)。

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Nurr1 Agonist 14

Nurr1 Agonist 14 Chemical Structure

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Nurr1 Agonist 14 相关抗体

Top Publications Citing Use of Products

查看 Nuclear Hormone Receptor 4A/NR4A 亚型特异性产品:

查看所有亚型
Nur77/NR4A1 Nurr1/NR4A2

查看 IAP 亚型特异性产品:

查看所有亚型
cIAP cIAP-1 cIAP-2 XIAP

查看 Calcium Channel 亚型特异性产品:

查看所有亚型
N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nurr1 Agonist 14 (Compound 32) is a Nurr1 agonist with an EC50 of 0.09  μM for Nurr1. Nurr1 Agonist 14 has significant neuroprotective activity with no influence of residual DHODH inhibition. Nurr1 Agonist 14 upregulates neuroprotective genes including SOD2, SESN3, BIRC5, XIAP, FLRT2 and CRMP4 in dopaminergic neurons. Nurr1 Agonist 14 can be used for neurodegenerative diseases such as Alzheimer′s disease (AD), Parkinson′s disease (PD) and multiple sclerosis (MS) research[1].

IC50 & Target[1]

XIAP

 

Nurr1/NR4A2

0.09 μM (EC50)

分子量

379.39

Formula

C20H18FN5O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nurr1 Agonist 14 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nurr1 Agonist 14Nuclear Hormone Receptor 4A/NR4ASODIAPSurvivinCalcium ChannelNuclear Hormone Receptor 4ANerve Growth Factor IB-like ReceptorSuperoxide DismutaseCa2+ channelsCa channelsAgonistNurr1NeuroprotectiveDHODH inhibitionDopaminergic neuronsNeurodegenerative diseasesADPDMSInhibitorinhibitorinhibit

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