2. Gene
  3. CSF2RB - colony stimulating factor 2 receptor subunit beta Gene

CSF2RB - colony stimulating factor 2 receptor subunit beta Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：集落刺激因子 2 受体亚基 β

种属: Homo sapiens

同用名: CD131; IL3RB; IL5RB; SMDP5; CDw131; betaGMR

基因 ID: 1439 | 基因类型: protein coding

关于 CSF2RB

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:36,913,628-36,940,439 (from NCBI)

This gene has 3 transcripts (splice variants), 132 orthologues, 7 paralogues and is associated with 2 phenotypes. Biased expression in appendix (RPKM 40.5), lymph node (RPKM 21.2) and 12 other tissues.

功能概要

该基因编码的蛋白质是 IL-3、IL-5 和 CSF 的高亲和力受体的共同 β 链。据报道，该基因的缺陷与蛋白质肺泡蛋白沉积症 (PAP) 有关。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008]

CSF2RB 基因产物(2)

mRNA Protein Name
NM_000395.3 NP_000386.1 cytokine receptor common subunit beta isoform 2 precursor
NM_001410827.1 NP_001397756.1 cytokine receptor common subunit beta isoform 1 precursor

CSF2RB 蛋白结构

IL6Ra-bind

IL6Ra-bind: Interleukin-6 receptor alpha chain, binding (245 - 338)

fn3

fn3: Fibronectin type III domain (341 - 419)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 897 a.a.
蛋白主名 其他名称

cytokine receptor common subunit beta

GM-CSF/IL-3/IL-5 receptor common beta subunit

重组 CSF2RB 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73032 EPOR-CD131 Heterodimer Protein, Human (HEK293, Fc) P19235 (A25-P250)&P32927 (W17-W443) ≥95%
HY-P75608 CD131 Protein, Human (HEK293, His) P32927 (W17-W443) ≥95%

关联疾病

疾病名称 别名
Surfactant Metabolism Dysfunction, Pulmonary, 5

SMDP5

Pulmonary Alveolar Proteinosis 5

Pap Due To Csf2rb Deficiency

Csf2rb Deficiency

Pulmonary Surfactant Metabolism Dysfunction 5

Pap5

Surfactant Metabolism Dysfunction, Pulmonary, Type 5
Hereditary Pulmonary Alveolar Proteinosis

Congenital Pap

Congenital Pulmonary Alveolar Proteinosis

Pulmonary Alveolar Proteinosis, Congenital
Pulmonary Alveolar Proteinosis
Autosomal Dominant Beta Thalassemia

Inclusion Body Beta-Thalassemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03233 CSF2RB Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus CSF2RB VGNC VGNC:27756
Macaca mulatta CSF2RB VGNC VGNC:71518
Canis familiaris CSF2RB VGNC VGNC:39656
Rattus norvegicus CSF2RB RGD RGD:620189
Felis catus CSF2RB VGNC VGNC:61216
Others CSF2RB NCBI
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