2. Gene
  3. Gcg - glucagon Gene

Gcg - glucagon Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Glu; PPG; GLP-1

基因 ID: 14526 | 基因类型: protein coding

关于 Gcg

功能概要

This gene encodes glucagon, a pancreatic hormone that counteracts the action of Insulin in the bloodstream. The encoded protein is processed to generate glucagon and two Other glucagon-like peptides, GLP1 and GLP2. Glucagon stimulates gluconeogenesis, glycogenolysis and lipolysis. GLP1 induces secretion of Insulin, suppresses glucagon secretion and inhibits feeding. GLP2 induces intestinal absorption of glucose by stimulating the growth of intestinal cells and preventing Apoptosis. [provided by RefSeq, Apr 2015]

Gcg 基因产物(1)

mRNA Protein Name
NM_008100.4 NP_032126.1 pro-glucagon preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables receptor ligand activity IDA
IDA: 通过直接分析推断
30380405 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
19915011 MGI
involved in cellular response to glucagon stimulus IDA
IDA: 通过直接分析推断
30380405 MGI
acts upstream of gluconeogenesis IDA
IDA: 通过直接分析推断
24051374 MGI
involved in glucose homeostasis IDA
IDA: 通过直接分析推断
22037645 MGI
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
19915011 MGI
acts upstream of or within negative regulation of execution phase of apoptosis IDA
IDA: 通过直接分析推断
19915011 MGI
involved in negative regulation of intrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
19915011 MGI
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
19915011 MGI
involved in positive regulation of calcium ion import IDA
IDA: 通过直接分析推断
19915011 MGI
acts upstream of or within positive regulation of gluconeogenesis IDA
IDA: 通过直接分析推断
24051374 MGI
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IDA
IDA: 通过直接分析推断
19915011 MGI
involved in positive regulation of peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
19915011 MGI
involved in positive regulation of peptidyl-threonine phosphorylation IDA
IDA: 通过直接分析推断
19915011 MGI
involved in positive regulation of protein binding IDA
IDA: 通过直接分析推断
19915011 MGI
involved in positive regulation of protein kinase activity IDA
IDA: 通过直接分析推断
19915011 MGI
involved in protein kinase A signaling IMP
IMP: 通过突变表型推断
19915011 MGI
acts upstream of or within regulation of insulin secretion IDA
IDA: 通过直接分析推断
14736883 MGI
involved in regulation of insulin secretion IDA
IDA: 通过直接分析推断
22037645 MGI
involved in response to activity IDA
IDA: 通过直接分析推断
22037645 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
17928203 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
17693256 MGI
is active in plasma membrane IDA
IDA: 通过直接分析推断
30380405 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

pro-glucagon

glucagon-like peptide I

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-109556 Insulin Detemir Activator ≥95.0% 否
HY-118874 Oblimersen / 否
Clinical Phase
生物活性分子 (4)
目录号 产品名 作用方式
纯度 Phase
HY-132596 Tivanisiran Inhibitor 97.48% Phase 3
HY-148100 Emapticap pegol Inhibitor 91.38% Phase 2
HY-P10031A SAR441255 TFA Agonist 99.93% Phase 1
HY-P10031 SAR441255 Agonist 99.77% Phase 1
Pre-clinical Phase
生物活性分子 (11)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-109528 Fomivirsen sodium Inhibitor ≥99.0% 否
HY-150738 ODN 2088 Antagonist 98.82% 否
HY-150217 CpG ODN 10101 99.44% 否
HY-150736 ODN 20844 Inhibitor 92.60% 否
HY-150748 ODN D-SL01 Agonist 99.94% 否
HY-148412 Monarsen Inhibitor / 否
HY-150213 ODN BW001 Inhibitor / 否
HY-P5074 GRPP (human) Agonist / 否
HY-RS05323 GCG Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17156 Gcg Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23606 Gcg Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gcg NCBI NCBI:2641
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