1. PI3K/Akt/mTOR Stem Cell/Wnt MAPK/ERK Pathway
  2. Akt ERK
  3. Insulin Detemir

Insulin Detemir 

目录号: HY-109556 纯度: ≥95.0%
COA 产品使用指南

Insulin Detemir 是一种人工胰岛素,具有控制血糖水平的作用。Insulin Detemir 通过激活 Akt 和细胞外信号调节激酶 (ERK) 依赖的-cat 和 CREB 信号通路,促进 Gcg 表达,从而刺激 GLP-1 的分泌。地特胰岛素可用于 2 型糖尿病的研究。

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Custom Peptide Synthesis

Insulin Detemir Chemical Structure

Insulin Detemir Chemical Structure

CAS No. : 169148-63-4

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Insulin Detemir is an artificial insulin, shows effect on controlling blood sugar levels. Insulin Detemir stimulates GLP-1 secretion as a consequence of enhanced Gcg expression by a mechanism involving activation of Akt- and/or extracellular signal-regulated kinase (ERK)-dependent-cat and CREB signaling pathways. Insulin Detemir can be used for type 2 diabetes research[1][2].

体外研究
(In Vitro)

Insulin Detemir (d-INS) (100 nM; 0.5-4 h) increases Gcg mRNA expression in primary fetal rat intestinal cell (FRIC) cultures, and (100 nM; 5 min and 10 min) induces rapid phosphorylation of Akt, as well[1].
Insulin Detemir (100 nM; 5-120 min) increases β-catenin phosphorylation, its nuclear translocation, and enhances cAMP response element-binding protein (CREB) phosphorylation in a phosphatidylinositol 3-kinase and/or mitogen-activated protein kinase kinase/extracellular signal-regulated kinase-sensitive manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: GLUTag cells
Concentration: 100 nM
Incubation Time: 0, 5, 10, 30, 60, and 120 min
Result: Stimulated CREB, ERK1/2, Akt and its downstream glycogen synthase kinase (GSK)-3 phosphorylation at 5 min and 10 min.
体内研究
(In Vivo)

Insulin Detemir (d-INS) (5 IU/kg; i.p.; once daily; 2 weeks) demonstrates weight-sparing effects compared with other insulin formulations, and shows a intestinal tissues preference, potentially involving the activation of insulin/-catenin/CREB signaling pathways[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Obese type 2 diabetic db/db mice[1]
Dosage: 5 IU/kg
Administration: Intraperitoneal injection; once daily for 2 weeks
Result: Decreased body weight of the mice after 14-day daily injection of d-INS (5 IU/kg) significantly compared with those injected with the same dose of human Insulin or saline.
Induced rapid phosphorylation of protein kinase B (Akt) in the gut L cells of normal mice.
Clinical Trial
Formula

C267H402N64O76S6

CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Store at 4°C, do not freeze

纯度 & 产品资料

纯度: ≥95.0%

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Insulin Detemir
目录号:
HY-109556
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