2. Gene
  3. CST5 - cystatin D Gene

CST5 - cystatin D Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：胱抑素 D

种属: Homo sapiens

基因 ID: 1473 | 基因类型: protein coding

关于 CST5

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:23,875,934-23,879,748 (from NCBI)

This gene has 1 transcript (splice variant), 122 orthologues and 11 paralogues. Restricted expression toward salivary gland (RPKM 368.3).

功能概要

胱抑素超家族包括含有多个胱抑素样序列的蛋白质。一些成员是活性半胱氨酸蛋白酶抑制剂，而其他成员则失去或可能从未获得这种抑制活性。超家族中有三个抑制家族，包括 1 型胱抑素 (stefins) 、2 型胱抑素和激肽原。 2 型胱抑素蛋白是一类半胱氨酸蛋白酶抑制剂，存在于多种人体体液和分泌物中。 20 号染色体上的胱抑素基因座包含大多数 2 型胱抑素基因和假基因。该基因位于胱抑素位点，编码唾液和眼泪中的一种蛋白质。编码的蛋白质可能对口腔中存在的蛋白酶起保护作用。[RefSeq 提供，2008 年 7 月]

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine Protease Inhibitors, while Others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein found in saliva and tears. The encoded protein may play a protective role against proteinases present in the oral cavity. [provided by RefSeq, Jul 2008]

CST5 基因产物(1)

mRNA Protein Name
NM_001900.5 NP_001891.2 cystatin-D precursor

CST5 蛋白结构

Cystatin

Cystatin: Cystatin domain (32 - 128)

  • 0
  • 100
  • 142 a.a.
蛋白主名 其他名称

cystatin-D

cystatin 5

重组 CST5 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70020 Cystatin D/CST5 Protein, Human (HEK293, His) P28325 (G21-V142) ≥95%

关联疾病

疾病名称 别名
Cerebral Amyloid Angiopathy, Cst3-Related

Cerebral Amyloid Angiopathy

Hereditary Cerebral Hemorrhage With Amyloidosis

Hchwa

Hereditary Cystatin C Amyloid Angiopathy

Cerebral Amyloid Angiopathy, Familial

Amyloidosis, Cerebroarterial, Icelandic Type

Amyloidosis Vi

Cerebral Hemorrhage, Hereditary, With Amyloidosis

Cst3-Related Cerebral Amyloid Angiopathy

Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant

Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant

Caa, Familial

Cerebral Amyloid Angiopathy, Genetic

Acys Amyloidosis

Cst3-Related Amyloidosis

Cystatin Amyloidosis

Hchwa, Icelandic Type

Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type

Amyloidosis 6

AMYL6

Acys

Caa

Cerebral Amyloid Angiopathy Cst3-Related

Cerebroarterial Amyloidosis Icelandic Type

Cystatin C Amyloidosis

Hccaa

Hchwai

Hchwa-I

Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type

Cerebral Amyloid Angiopathy Familial

Angiopathy, Amyloid, Cerebral, Cst3-Related

Hereditary Cerebral Amyloid Angiopathy, Icelandic Type

Familial Cerebral Amyloid Angiopathy

Cerebral Amyloid Angiopathy, Hereditary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03266 CST5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CST5 RGD RGD:1310978
Mus musculus CST5 MGD MGI:1930004
Macaca mulatta CST5 VGNC VGNC:71530
Others CST5 NCBI
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