2. Gene
  3. Spsb2 - splA/ryanodine receptor domain and SOCS box containing 2 Gene

Spsb2 - splA/ryanodine receptor domain and SOCS box containing 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: C9; SSB2; Grcc9

基因 ID: 14794 | 基因类型: protein coding

关于 Spsb2

功能概要

This gene encodes a member of the SSB family of proteins that contain a central SPRY (repeats in splA and ryanodine receptors) domain and a C-terminal SOCS (suppressor of cytokine signaling) box. The encoded protein is an adaptor protein in the E3 ubiquitin Ligase complex that ubiquitinates inducible nitric oxide synthase and targets it for proteasomal degradation. Mice lacking the encoded protein exhibit lower blood urea nitrogen levels and mild thrombocytopenia due to reduced platelet production. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Spsb2 基因产物(10)

mRNA Protein Name
NM_001306050.2 NP_001292979.1 SPRY domain-containing SOCS box protein 2 isoform 1
NM_001306051.2 NP_001292980.1 SPRY domain-containing SOCS box protein 2 isoform 1
NM_001306052.2 NP_001292981.1 SPRY domain-containing SOCS box protein 2 isoform 1
NM_001306053.2 NP_001292982.1 SPRY domain-containing SOCS box protein 2 isoform 2
NM_001409886.1 NP_001396815.1 SPRY domain-containing SOCS box protein 2 isoform 1
NM_001409887.1 NP_001396816.1 SPRY domain-containing SOCS box protein 2 isoform 1
NM_001409888.1 NP_001396817.1 SPRY domain-containing SOCS box protein 2 isoform 2
NM_001409889.1 NP_001396818.1 SPRY domain-containing SOCS box protein 2 isoform 2
NM_001409890.1 NP_001396819.1 SPRY domain-containing SOCS box protein 2 isoform 2
NM_013539.3 NP_038567.1 SPRY domain-containing SOCS box protein 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16369487 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
20603330 MGI
involved in ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
20603330 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

SPRY domain-containing SOCS box protein 2

gene-rich cluster protein C9

Spsb2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Spsb2 O88838 PAWR Homo sapiens Q96IZ0
NMR
20561531
种属间
Spsb2 O88838 PAWR Homo sapiens Q96IZ0
Anti Tag CoIP
16369487
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P10383 SPSB2-iNOS inhibitory cyclic peptide-1 99.81% 否
HY-P10383A SPSB2-iNOS inhibitory cyclic peptide-1 TFA / 否
HY-P10384 SPSB2-iNOS inhibitory cyclic peptide-2 Inhibitor / 否
HY-P10384A SPSB2-iNOS inhibitory cyclic peptide-2 TFA / 否
HY-P10385 SPSB2-iNOS inhibitory cyclic peptide-3 / 否
HY-P10385A SPSB2-iNOS inhibitory cyclic peptide-3 TFA / 否
HY-RS13727 SPSB2 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Spsb2 NCBI NCBI:84727
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