2. Gene
  3. BROX - BRO1 domain and CAAX motif containing Gene

BROX - BRO1 domain and CAAX motif containing Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 BRO1 结构域和 CAAX 基序

种属: Homo sapiens

同用名: C1orf58

基因 ID: 148362 | 基因类型: protein coding

关于 BROX

This gene has 9 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in colon (RPKM 10.5), brain (RPKM 10.3) and 25 other tissues.

功能概要

位于细胞外外泌体。 [由基因组资源联盟提供，2022 年 4 月]

Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

BROX 基因产物(6)

mRNA Protein Name
NM_001288579.2 NP_001275508.1 BRO1 domain-containing protein BROX isoform b
NM_001288580.2 NP_001275509.1 BRO1 domain-containing protein BROX isoform b
NM_001288581.2 NP_001275510.1 BRO1 domain-containing protein BROX isoform c
NM_001375661.1 NP_001362590.1 BRO1 domain-containing protein BROX isoform a
NM_001375758.1 NP_001362687.1 BRO1 domain-containing protein BROX isoform d
NM_144695.4 NP_653296.2 BRO1 domain-containing protein BROX isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22162750 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mitotic nuclear membrane reassembly IMP
IMP: 通过突变表型推断
34818527 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nuclear envelope IDA
IDA: 通过直接分析推断
34818527 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BROX 蛋白结构

BRO1

BRO1: BRO1-like domain (63 - 357)

  • 0
  • 100
  • 200
  • 300
  • 411 a.a.
蛋白主名 其他名称

BRO1 domain-containing protein BROX

BROX 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
BROX Q5VW32 CHMP5 Homo sapiens Q9NZZ3-1
FPS
22484091
种属内
BROX Q5VW32 CHMP5 Homo sapiens Q9NZZ3-1
Anti Tag CoIP
22484091
种属内
BROX Q5VW32 CHMP5 Homo sapiens Q9NZZ3-1
X-Ray Diffraction
22484091
种属内
BROX Q5VW32 TCEA1 Homo sapiens P23193
Anti Tag CoIP
33961781
种属内
BROX Q5VW32 TCEA1 Homo sapiens P23193
Anti Tag CoIP
28514442
种属内
BROX Q5VW32 CHMP4B Homo sapiens Q9H444
X-Ray Diffraction
22484091
种属内
BROX Q5VW32 CHMP4B Homo sapiens Q9H444
Anti Tag CoIP
22484091
种属内
BROX Q5VW32 CHMP4B Homo sapiens Q9H444
FPS
22484091
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Central Nervous System Sarcoma

Sarcoma Of The Cns
Developmental And Epileptic Encephalopathy 12

Epileptic Encephalopathy, Early Infantile, 12

DEE12

Eiee12

Early Infantile Epileptic Encephalopathy 12

Developmental And Epileptic Encephalopathy, 12

Encephalopathy, Epileptic, Early Infantile, Type 12
Breast Ductal Adenoma
Methemoglobinemia And Ambiguous Genitalia

METAG

Methemoglobinemia Type Iv

Isolated 17,20-Lyase Deficiency, Pure

Methemoglobinemia Due To Deficiency Of Cytochrome B5

Methemoglobinemia Type 4

Methemoglobinemia Type Iv, Formerly

Methemoglobinemia Due To Deficiency Of Cytochrome B5, Formerly

Pure Isolated 17,20-Lyase Deficiency

Methemoglobinemia, Type Iv
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01627 BROX Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22111 Brox Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28633 Brox Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus BROX VGNC VGNC:26571
Felis catus BROX VGNC VGNC:60180
Canis familiaris BROX VGNC VGNC:38532
Rattus norvegicus BROX RGD RGD:1307161
Macaca mulatta BROX VGNC VGNC:70399
Mus musculus BROX MGD MGI:1918928
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