2. Gene
  3. PLB1 - phospholipase B1 Gene

PLB1 - phospholipase B1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷脂酶 B1

种属: Homo sapiens

同用名: PLB; PLB/LIP

基因 ID: 151056 | 基因类型: protein coding

关于 PLB1

Cytogenetic location: 2p23.2 Genomic coordinates (GRCh38): 2:28,496,060-28,644,142 (from NCBI)

This gene has 12 transcripts (splice variants) and 211 orthologues. Biased expression in small intestine (RPKM 8.9), bone marrow (RPKM 1.8) and 8 other tissues.

功能概要

该基因编码膜相关磷脂酶，通过去除甘油磷脂的 sn-1 和 sn-2 脂肪酸显示溶血磷脂酶和磷脂酶 A2 活性。此外，它还具有脂肪酶和视黄酯水解酶活性。编码的蛋白质高度保守，由一个大的糖基化细胞外结构域组成，该结构域由四个串联同源结构域组成，然后是将酶锚定在膜上的疏水片段和一个短的 C 末端胞质尾部。该基因已被确定为类风湿性关节炎的候选风险基因。[RefSeq 提供，2016 年 7 月]

This gene encodes a membrane-associated Phospholipase that displays lysophospholipase and Phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays Lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been identified as a candidate rheumatoid arthritis risk gene. [provided by RefSeq, Jul 2016]

PLB1 基因产物(2)

mRNA Protein Name
NM_001170585.2 NP_001164056.1 phospholipase B1, membrane-associated isoform 2 precursor
NM_153021.5 NP_694566.4 phospholipase B1, membrane-associated isoform 1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PLB1 蛋白结构

Lipase_GDSL

Lipase_GDSL: GDSL-like Lipase/Acylhydrolase (394 - 667)

Lipase_GDSL

Lipase_GDSL: GDSL-like Lipase/Acylhydrolase (741 - 1015)

Lipase_GDSL

Lipase_GDSL: GDSL-like Lipase/Acylhydrolase (1097 - 1361)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1458 a.a.
蛋白主名 其他名称

phospholipase B1, membrane-associated

lysophospholipase

关联疾病

疾病名称 别名
Fungal Meningitis

Meningitis, Fungal

Mycotic Meningitis
Denture Stomatitis

Stomatitis, Denture

Denture Sore Mouth
Cryptococcal Meningitis

Meningitis, Cryptococcal

Meningitis Cryptococcal
Cryptococcosis

Cryptococcus Neoformans Infection

Torulosis

Busse-Buschke'S Disease

Cryptococcal Infection

European Cryptococcosis

Torula

Infection By Cryptococcus Neoformans

Cryptococcosis Infection

European Blastomycosis

European Blastomycotic Infection

European Blastomycoses Infection

Torula Histolytica Infection
Mucinous Bronchioloalveolar Adenocarcinoma

Bronchiolo-Alveolar Carcinoma, Mucinous
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Opportunistic Mycosis

Opportunistic Mycoses

Opportunistic Systemic Mycoses
Fungal Infectious Disease

Mycoses

Mycosis
Amyotrophic Lateral Sclerosis Type 6

Amyotrophic Lateral Sclerosis 6, Autosomal Recessive

Als6

Amyotrophic Lateral Sclerosis 6, With Or Without Frontotemporal Dementia

Autosomal Recessive Amyotrophic Lateral Sclerosis 6

Sclerosis, Lateral, Amyotrophic, Type Type 6

Amyotrophic Lateral Sclerosis 6
Meningoencephalitis

Acquired Toxoplasmal Meningoencephalitis

Meningoencephalitis Due To Acquired Toxoplasmosis

Meningoencephalitis Due To Toxoplasmosis

Toxoplasma Meningoencephalitis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10649 PLB1 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PLB1 VGNC VGNC:76137
Bos taurus PLB1 VGNC VGNC:32977
Felis catus PLB1 VGNC VGNC:64205
Rattus norvegicus PLB1 RGD RGD:621565
Mus musculus PLB1 MGD MGI:1922406
Canis familiaris PLB1 VGNC VGNC:44641
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