1. Gene
  2. CTSL - cathepsin L Gene

CTSL - cathepsin L Gene

中文名称:组织蛋白酶 L

种属: Homo sapiens

同用名: MEP; CATL; CTSL1

基因 ID: 1514 | 基因类型: protein coding

关于 CTSL

Cytogenetic location: 9q21.33 Genomic coordinates (GRCh38): 9:87,726,119-87,731,469 (from NCBI)

This gene has 43 transcripts (splice variants), 708 orthologues and 12 paralogues. Broad expression in placenta (RPKM 162.6), kidney (RPKM 60.4) and 23 other tissues.

功能概要

该基因编码的蛋白质是一种溶酶体半胱氨酸蛋白酶,在细胞内蛋白质分解代谢中起主要作用。其底物包括胶原蛋白和弹性蛋白,以及 alpha-1 蛋白酶抑制剂,这是中性粒细胞弹性蛋白酶活性的主要控制元素。编码的蛋白质涉及多种病理过程,包括肌病和心肌缺血中的肌原纤维坏死,以及肾小管对蛋白尿的反应。这种蛋白质是肽酶 C1 家族的一员,是由二硫键连接的重链和轻链组成的二聚体,均由单一蛋白质前体产生。此外,这种蛋白质会切割 SARS-CoV-2 刺突蛋白的 S1 亚基,这是病毒进入细胞所必需的。[RefSeq 提供,2020 年 8 月]

The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil Elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and LIGHT chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell. [provided by RefSeq, Aug 2020]

CTSL 基因产物(10)

mRNA Protein Name
NM_001257971.2 NP_001244900.1 procathepsin L isoform 1 preproprotein
NM_001382767.1 NP_001369696.1 procathepsin L isoform 4 precursor
NM_001257972.2 NP_001244901.1 procathepsin L isoform 1 preproprotein
NM_001912.5 NP_001903.1 procathepsin L isoform 1 preproprotein
NM_001382768.1 NP_001369697.1 procathepsin L isoform 4 precursor
NM_001382766.1 NP_001369695.1 procathepsin L isoform 4 precursor
NM_001382758.1 NP_001369687.1 procathepsin L isoform 3
NM_145918.3 NP_666023.1 procathepsin L isoform 1 preproprotein
NM_001382757.1 NP_001369686.1 procathepsin L isoform 1 preproprotein
NM_001257973.2 NP_001244902.1 procathepsin L isoform 2

CTSL 蛋白结构

Inhibitor_I29

Inhibitor_I29: Cathepsin propeptide inhibitor domain (I29) (29 - 88)

Peptidase_C1

Peptidase_C1: Papain family cysteine protease (115 - 332)

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  • 333 a.a.
蛋白主名 其他名称

procathepsin L

cathepsin L1

major excreted protein

重组 CTSL 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7754 Cathepsin L1 Protein, Human (HEK293, His) P07711 (T18-V333) ≥95%

关联疾病

疾病名称 别名
Taeniasis

Beef Tapeworm Infection

Infection By Taeniarhynchus Saginatus

Taenia Saginata Infectious Disease

Taenia Saginata Infection

Pork Tapeworm Infection

Armed Tapeworm Infection

Infection By Taenia Solium

Intestinal Taenia Solium Infection

Pork Tapeworm

Taenia Solium Taeniasis

Adult Pork Tapeworm Infection

Adult Pork Tapeworm

Beef Tapeworm

Infection By Taenia Saginata

Unarmed Tapeworm Infection

Taenia Saginata Taeniasis

Infection Due To Adult Tapeworm Taenia Saginata

Mediocanellata Taenia Infection

Infestation By Taenia Saginata

Infestation By Taenia Mediocanellata

Monieziasis
Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis

Batten Disease

Ncl

Neuronal Ceroid-Lipofuscinoses

Lipofuscinosis, Ceroid, Neuronal

Juvenile Neuronal Ceroid Lipofuscinosis

Cerebromacular Dystrophy

Cerebromacular Degeneration

Ceroid-Lipofuscinosis

Ncl - [Neuronal Ceroid Lipofuscinosis]

Amaurotic Familial Idiocy

Amaurotic Idiocy

Amaurotic Idiot

Neuronal Lipofuscinosis

Pigmentary Retinal Lipoid Neuronal Heredodegeneration

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Ischemia

Acute Coronary Syndrome

Aortic Aneurysm, Familial Abdominal, 1

Abdominal Aortic Aneurysm

Aortic Aneurysm, Familial Abdominal 1

Aneurysm, Abdominal Aortic

AAA

Aortic Aneurysm, Abdominal

AAA1

Aortic Aneurysm, Familial Abdominal

Aortic Aneurysm Abdominal

Abdominal Aortic Aneurysms

Abdominal Aortic Aneurysm Without Mention Of Perforation Or Rupture

Abdomen Aneurysm

Abdominal Aorta Aneurysm

Aneurysm Of Abdominal Aorta

Aortic Abdomen Aneurysm

Aaa - [Abdominal Aortic Aneurysm]

Abdominal Aneurysm

Abdominal Aorta Aneurysm Rupture

Abdominal Aorta Aneurysm Ruptured

Abdominal Aortic Aneurysm Which Has Ruptured

Ruptured Aaa

Abdomen Aorta Aneurysm Ruptured

Abdomen Aorta Rupture

Abdomen Aortic Aneurysm Rupture

Abdomen Aneurysm Rupture

Abdomen Aortic Aneurysm Ruptured

Abdomen Aortic Rupture

Abdominal Aorta Rupture

Abdominal Aortic Rupture

Rupture Abdomen Aorta Aneurysm

Rupture Abdominal Aortic Aneurysm

Ruptured Abdomen Aneurysm

Ruptured Abdomen Aorta

Ruptured Abdomen Aortic

Ruptured Abdominal Aneurysm

Ruptured Abdominal Aorta

Ruptured Abdominal Aortic

Ruptured Aorta Abdominalis Aneurysm

False Abdomen Aorta Aneurysm Ruptured

False Abdominal Aortic Aneurysm Ruptured

False Abdominal Aorta Aneurysm Ruptured

False Abdomen Aortic Aneurysm Ruptured

Tick Infestation

Tick Infestations

Fascioliasis

Fasciola Hepatica Infection

Infection By Fasciola

Sheep Liver Fluke Infection

Liver Flukes

Fasciola Infestation

Sheep Liver Fluke Disease

Liver Fluke Infestation

Liver Flukes Nos

Liver Fluke Infection

Liver Fluke Disease

Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site

Toxocariasis

Toxocara Infection

Visceral Larva Migrans

Larva Migrans, Visceral

Infection By Toxascaris

Larva Migrans Visceral

Larva Migrans Visceralis

Toxocaral Visceral Larva Migrans

Visceral Larva Migrans Syndrome

Toxocara Infestation

Heterophyiasis

Heterophyes Infectious Disease

Trichomoniasis

Trichomonas Infection

Trichomonas Infections

Disease Due To Trichomonadidae

Infection By Trichomonas

Trichomonadosis

Trichomonas Pruritus

Trichomonosis

Tricomoniasis

Gingival Overgrowth

Gingival Enlargement

Gingival Hyperplasia

Gingival Bulge

Gingival Enlargement Nos

Gingival Hypertrophy

Gum Hypertrophy

Hyperplasia Gum

Gingival Thickening

Hyperplasia Of Gingiva

Hypertrophy Of Gingiva

Hypertrophy Of Mucous Membrane Of Gums

Vascular Disease

Vascular Diseases

Aneurysm

Spinal Cord Ischemia

Spinal Cord Vascular Diseases

Vascular Tissue Disease

Vascular Anomaly

Parasitic Helminthiasis Infectious Disease

Helminthiasis

Intestinal Helminthiasis

Helminth Infection

Helminthosis

Worm Infection

Worm Infections

Helminth Infections

Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata

Parasitic Enteritis

Metazoal Dysentery

Intestinal Worms Nos

Ebola Hemorrhagic Fever

Ebola Virus Disease

Viral Hemorrhagic Fever

Hemorrhagic Fever, Ebola

Ehf

Ebola Fever

Ebola

Hemorrhagic Fevers, Viral

Ebola Haemorrhagic Fever

Ebod - [Ebola Disease]

Evd - [Ebola Virus Disease]

Ebola Virus Haemorrhagic Fever

Vhf - [Viral Haemorrhagic Fever] Nos

Viral Haemorrhagic Fever, Not Otherwise Specified

Papillon-Lefevre Syndrome

Papillon-Lefevre Disease

Papillon-Lefèvre Syndrome

PLS

Keratosis Palmoplantaris With Periodontopathia

PALS

Papillon Lefevre Syndrome

Keratosis Palmoplantar-Periodontopathy Syndrome

Papillon-Lefvre Syndrome

Hyperkeratosis Palmoplantaris With Periodontosis

Keratoris Palmoplantaris With Periodontopathia

Keratosis Palmoplantar - Periodontopathy

Palmar-Plantar Hyperkeratosis And Concomitant Periodontal Destruction

Palmoplantar Keratoderma With Periodontosis

Palsy

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Covid-19

2019 Novel Coronavirus

2019-Ncov Infection

Covid19

Sars-Cov-2 Infection

Wuhan Coronavirus Infection

Wuhan Seafood Market Pneumonia Virus Infection

Sleeping Sickness

African Trypanosomiasis

African Sleeping Sickness

Trypanosomiasis, Human East-African

Trypanosomiasis, East African

Trypanosomiasis African

Trypanosomiasis, African

Human African Trypanosomiasis

Middle East Respiratory Syndrome

Mers

Mers - [Middle East Respiratory Syndrome]

Sparganosis

Infection By Sparganum

Larval Diphyllobothriasis

Spirometrosis

Infection By Spirometra Larvae

Larval Dibothriocephaliasis

Sparganosis - Larval Diphyllobothriasis

Spirometriosis

Larval Dibothriocephalus Infestation

Larval Diphyllobothrium Infestation

Larval Dibothriocephalus

Infection Due To Sparganum

Larval Fish Tapeworm Infection

Spirometra Larvae Infestation

Sparganum Infestation

Larval Bothriocephalus Infestation

Metagonimiasis

Trematode Infections

Infection By Metagonimus Yokogawai

Metagonimus Yokogawai Infection

Severe Acute Respiratory Syndrome

Sars

Sars-Cov Infection

Sars-1

Sar Deficiency

Sars - [Severe Acute Respiratory Syndrome]

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

Focal Glomerulosclerosis

Fsgs

Segmental Glomerulosclerosis

Glomerulosclerosis, Focal Segmental

Fgs

Focal Glomerular Sclerosis

Familial Idiopathic Nephrotic Syndrome

Focal Sclerosis With Hyalinosis

Glomerulosclerosis, Focal

Glomerulosclerosis Focal

Glomerulosclerosis, Segmental, Focal

Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Amebiasis

Amoebiasis

Entamoebiasis

Chronic Intestinal Amebiasis

Amoebiasis, Unspecified

Amebic Colitis

Amoebic Enteritis

Infection Due To Entamoeba Histolytica

Amoebic Infection

Disease Due To Endamoebidae

Amoebiasis Nos

Keratosis Follicularis Spinulosa Decalvans, Autosomal Dominant

Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans

KFSD

Parasitic Protozoa Infectious Disease

Protozoan Infections

Mastigophora Infectious Disease

Sarcomastigophora Infectious Disease

Coronavirus Infectious Disease
Dicrocoeliasis

Disease Due To Dicrocoeliidae

Lancet Fluke Infection

Dicroceliosis

Lancet Fluke Disease

Lancet Fluke Infestation

Leukodystrophy

Leukodystrophies

Unverricht-Lundborg Syndrome

Unverricht-Lundborg Disease

Epm1

Myoclonic Epilepsy Of Unverricht And Lundborg

Myoclonus Progressive Epilepsy Of Unverricht And Lundborg

Unverricht - Lundborg Disease

Unverricht'S Disease

Epilepsy, Progressive Myoclonic Type 1

Epilepsy, Progressive Myoclonus 1

Progressive Myoclonus Epilepsy Baltic Myoclonic Epilepsy

Baltic Myoclonic Epilepsy

Baltic Myoclonus

Baltic Myoclonus Epilepsy

Lundborg-Unverricht Syndrome

Mediterranean Myoclonic Epilepsy

Pme

Progressive Myoclonic Epilepsy

Progressive Myoclonus Epilepsy 1

Uld

Myoclonic Epilepsies, Progressive

Benign Meningioma

Meningioma, Benign

Progressive Myoclonus Epilepsy

Pme

Progressive Myoclonic Epilepsy

Myoclonic Epilepsies, Progressive

Unverricht-Lundborg Syndrome

Paragonimiasis

Infection By Paragonimus

Lung Fluke Disease

Lung Fluke Infection

Pulmonary Paragonimiasis

Paragonimus Westermani Infection

Pulmonary Distomiasis

Parasitic Haemoptysis

Oriental Lung Fluke Disease

Endemic Haemoptysis

Paragonimosis

Pulmonary Distomatosis

Lung Fluke Disorder

Infestation By Paragonimus

Infection Due To Paragonimus Species

Infestation Due To Paragonimus Species

Oriental Lung Fluke Infestation

Endemic Oriental Haemoptysis

Pycnodysostosis

Pyknodysostosis

PKND

Pycd

Toulouse-Lautrec Syndrome

Marburg Hemorrhagic Fever

Marburg Virus Disease

Marburg Disease

Green Monkey Disease

Mhf

Vervet Monkey Disease

Mard - [Marburg Disease]

Mvd - [Marburg Virus Disease]

Marburg Haemorrhagic Fever

Mhf - [Marburg Haemorrhagic Fever]

Trypanosomiasis
Cysticercosis

Neurocysticercosis

Submacular Cysticercosis

Intestinal Taenia Solium Infection

Pork Tapeworm Infection

Tapeworm Infection: Intestinal Taenia Solum

Tapeworm Infection: Pork

Tenia Solium Infectious Disease

Taeniasis

Tenia Solium Infection

Cysticerciasis Infection Due To Larval Form Of Taenia Solium

Parasitic Ectoparasitic Infectious Disease

Ectoparasitic Infestations

Ectoparasitism

Mandibular Cancer

Mandibular Neoplasms

Malignant Neoplasm Of Inferior Maxilla

Malignant Neoplasm Of Lower Jaw Bone

Malignant Neoplasm Of Mandible

Mandible Cancer

Mandibular Neoplasm

Neoplasm Of Mandible

Clonorchiasis

Oriental Liver Fluke Disease

Clonorchis Liver Infection

Clonorchiosis

Chinese Liver Fluke Disease

Hepatic Distomiasis Due To Clonorchis Sinensis

Infection Due To Clonorchis Sinensis

Hepatic Distomiasis

Hepatic Distomatosis

Chinese Liver Fluke Disorder

Oriental Liver Fluke Disorder

Clonorchis Infestation

Chinese Liver Fluke Infestation

Liver Fluke Disease Due To Clonorchis Sinensis

Oriental Liver Fluke Infestation

Metachromatic Leukodystrophy

Arylsulfatase A Deficiency

MLD

Arsa Deficiency

Sulfatide Lipidosis

Metachromatic Leukoencephalopathy

Cerebral Sclerosis, Diffuse, Metachromatic Form

Cerebroside Sulfatase Deficiency

Leukodystrophy, Metachromatic

Pseudoarylsulfatase A Deficiency

Leukodystrophy Metachromatic

Sulfatidosis

Metachromatic Leukodystrophy, Late Infantile

Metachromatic Leukodystrophy Variant

Deficiency Of Cerebroside-Sulfatase

Scholz Cerebral Sclerosis

Sulfatide Lipoidosis

Cerebral Sclerosis Diffuse Metachromatic Form

Arylsulfatase A Deficiency Disease

Cerebroside Sulphatase Deficiency Disease

Greenfield Disease

Metachromatic Leukodystrophy, Adult

Metachromatic Leukodystrophy, Juvenile

Leukodystrophy Metachromatic Adult

Leukodystrophy Metachromatic Juvenile

Leukodystrophy Metachromatic Late Infantile

Metachromatic Leukodystrophy, Adult Type

Metachromatic Leukodystrophy, Juvenile Type

Metachromatic Leukodystrophy, Infant

Greenfield'S Disease

Primary Amebic Meningoencephalitis

Pam

Naegleria Fowleri Infection

Meningoencephalitis Caused By Naegleria Fowleri

Primary Amoebic Meningoencephalitis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta CTSL VGNC VGNC:71560
Mus musculus CTSL MGD MGI:88564
Rattus norvegicus CTSL RGD RGD:2448
Others CTSL NCBI