Cathepsin L1 蛋白, Human (HEK293, His)

Cathepsin L1 Protein, Human (HEK293, His) is a major cysteine protease that plays a major role in intracellular protein catabolism.

组织蛋白酶 L1 是寄生虫分泌的一种主要半胱氨酸蛋白酶，在其致病性的各个方面发挥着关键作用。例如，组织蛋白酶 L1 通过将宿主蛋白分解代谢为可吸收的肽来参与营养获取，通过裂解纤连蛋白、层粘连蛋白和天然胶原蛋白等间质基质蛋白，促进寄生虫通过宿主肠道和肝脏的迁移，并参与通过裂解免疫球蛋白使宿主免疫防御失活。组织蛋白酶 L1 会抑制受感染实验动物的 Th1 免疫反应，使它们容易同时受到细菌感染^[1]。

Biological activity has been tested in vitro.

Human

HEK293

C-6*His

P07711 (T18-V333)

1514  [NCBI]

TLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTVHHHHHH

Approximately 34 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filter solution of 20 mM HAc-NaAc, 150 mM NaCl, pH 4.5.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.

• [1]. Panat Anuracpreeda, et al. Production and characterization of a monoclonal antibody against recombinant cathepsin L1 of Fasciola gigantica. Acta Trop. 2014 Aug;136:1-9.  [Content Brief]