2. Gene
  3. UPP2 - uridine phosphorylase 2 Gene

UPP2 - uridine phosphorylase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：尿苷磷酸化酶 2

种属: Homo sapiens

同用名: UP2; UPASE2; UDRPASE2

基因 ID: 151531 | 基因类型: protein coding

关于 UPP2

Cytogenetic location: 2q24.1 Genomic coordinates (GRCh38): 2:157,995,179-158,136,154 (from NCBI)

This gene has 4 transcripts (splice variants), 187 orthologues and 1 paralogue. Restricted expression toward kidney (RPKM 10.8).

功能概要

启用脱氧尿苷磷酸化酶活性；相同的蛋白质结合活性；和尿苷磷酸化酶活性。参与 dCMP 分解代谢过程和尿苷分解代谢过程。位于 III 型中间丝。 [由基因组资源联盟提供，2022 年 4 月]

Enables deoxyuridine Phosphorylase activity; identical protein binding activity; and uridine Phosphorylase activity. Involved in dCMP catabolic process and uridine catabolic process. Located in type III intermediate filament. [provided by Alliance of Genome Resources, Apr 2022]

UPP2 基因产物(2)

mRNA Protein Name
NM_001135098.2 NP_001128570.1 uridine phosphorylase 2 isoform b
NM_173355.4 NP_775491.1 uridine phosphorylase 2 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables deoxyuridine phosphorylase activity IDA
IDA: 通过直接分析推断
12849978 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
21855639 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables uridine phosphorylase activity IDA
IDA: 通过直接分析推断
12849978 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in dCMP catabolic process IDA
IDA: 通过直接分析推断
12849978 GOA
involved in uridine catabolic process IDA
IDA: 通过直接分析推断
12849978 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in type III intermediate filament IDA
IDA: 通过直接分析推断
11278417 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UPP2 蛋白结构

PNP_UDP_1

PNP_UDP_1: Phosphorylase superfamily (61 - 309)

  • 0
  • 100
  • 200
  • 317 a.a.
蛋白主名 其他名称

uridine phosphorylase 2

UPase 2

UPP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
UPP2 O95045 SIAH1 Homo sapiens Q8IUQ4
Validated Y2H
25416956
种属内
UPP2 O95045 UPP2 Homo sapiens O95045
Y2H Array
29892012
种属内
UPP2 O95045 SIAH1 Homo sapiens Q8IUQ4
Y2H Array
25416956
种属内
UPP2 O95045 UPP2 Homo sapiens O95045
Y2H Array
31515488
种属内
UPP2 O95045 CCZ1B Homo sapiens P86790
Anti Tag CoIP
33961781
种属内
UPP2 O95045 UPP2 Homo sapiens O95045
Y2H Array
25416956
种属内
UPP2 O95045 SIAH1 Homo sapiens Q8IUQ4
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Myopathy, Myosin Storage, Autosomal Dominant

MSMA

Myopathy, Hyaline Body, Autosomal Dominant

Myopathy With Lysis Of Type I Myofibrils

Autosomal Dominant Hyaline Body Myopathy

Hyaline Body Myopathy Autosomal Dominant
Terminal Osseous Dysplasia

Terminal Osseous Dysplasia And Pigmentary Defects

Terminal Osseous Dysplasia-Pigmentary Defects Syndrome

Todpd

TOD

Odpd

Odpf Syndrome

Osseous Dysplasia, Digital, With Facial Pigmentary Defects And Multiple Frenula

Odpf

Digital Osseous Dysplasia With Facial Pigmentary Defects And Multiple Frenula

Terminal Osseous Dysplasia With Pigmentary Defects

Dcd

Digitocutaneous Dysplasia

Terminal Osseous Dysplasia And Pigmentary Defect Syndrome

Osseous Dysplasia And Pigmentary Defects
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15491 UPP2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21452 Upp2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27970 Upp2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta UPP2 VGNC VGNC:79372
Rattus norvegicus UPP2 RGD RGD:1308188
Bos taurus UPP2 VGNC VGNC:36689
Mus musculus UPP2 MGD MGI:1923904
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