2. Gene
  3. Ptpn6 - protein tyrosine phosphatase, non-receptor type 6 Gene

Ptpn6 - protein tyrosine phosphatase, non-receptor type 6 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: me; hcp; Hcph; Ptp1C; SHP-1; 70Z-SHP; SH-PTP1; PTPTY-42

基因 ID: 15170 | 基因类型: protein coding

关于 Ptpn6

功能概要

Enables several functions, including phosphotyrosine residue binding activity; protein domain specific binding activity; and protein tyrosine Phosphatase activity. Involved in epididymis development; negative regulation of interleukin-6 production; and negative regulation of tumor necrosis factor production. Acts upstream of or within several processes, including hemopoiesis; negative regulation of protein phosphorylation; and regulation of lymphocyte activation. Located in cell-cell junction. Part of alpha-beta T cell receptor complex. Is expressed in several structures, including central nervous system; retina; and thymus primordium. Orthologous to human PTPN6 (protein tyrosine Phosphatase non-receptor type 6). [provided by Alliance of Genome Resources, Apr 2022]

Ptpn6 基因产物(2)

mRNA Protein Name
NM_001077705.2 NP_001071173.1 tyrosine-protein phosphatase non-receptor type 6 isoform b
NM_013545.3 NP_038573.2 tyrosine-protein phosphatase non-receptor type 6 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SH2 domain binding IDA
IDA: 通过直接分析推断
8632004 MGI
enables SH3 domain binding IDA
IDA: 通过直接分析推断
8632004 MGI
enables cell adhesion molecule binding IPI
IPI: 通过物理相互作用推断
19948503 MGI
enables phosphotyrosine residue binding IPI
IPI: 通过物理相互作用推断
10229828 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
8632004 MGI
enables protein tyrosine phosphatase activity IDA
IDA: 通过直接分析推断
8632004 MGI
enables protein tyrosine phosphatase activity IMP
IMP: 通过突变表型推断
11745335 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within B cell receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
23509253 MGI
acts upstream of or within B cell receptor signaling pathway IMP
IMP: 通过突变表型推断
9254656 MGI
acts upstream of MAPK cascade IMP
IMP: 通过突变表型推断
9064344 MGI
acts upstream of T cell proliferation IMP
IMP: 通过突变表型推断
9064344 MGI
acts upstream of T cell receptor signaling pathway IMP
IMP: 通过突变表型推断
9064344 MGI
involved in epididymis development IMP
IMP: 通过突变表型推断
11266449 MGI
acts upstream of or within hematopoietic progenitor cell differentiation IMP
IMP: 通过突变表型推断
24029230 MGI
acts upstream of or within intracellular signal transduction IDA
IDA: 通过直接分析推断
10229828 MGI
acts upstream of or within megakaryocyte development IMP
IMP: 通过突变表型推断
23509158 MGI
acts upstream of or within natural killer cell mediated cytotoxicity IMP
IMP: 通过突变表型推断
6971254 MGI
acts upstream of or within negative regulation of MAP kinase activity IMP
IMP: 通过突变表型推断
9064344 MGI
acts upstream of or within negative regulation of MAPK cascade IMP
IMP: 通过突变表型推断
9064344 MGI
acts upstream of or within negative regulation of T cell proliferation IMP
IMP: 通过突变表型推断
9064344 MGI
acts upstream of or within negative regulation of T cell receptor signaling pathway IMP
IMP: 通过突变表型推断
9064344 MGI
acts upstream of or within negative regulation of humoral immune response mediated by circulating immunoglobulin IMP
IMP: 通过突变表型推断
9254656 MGI
involved in negative regulation of inflammatory response to wounding IDA
IDA: 通过直接分析推断
27830702 MGI
involved in negative regulation of interleukin-6 production IGI
IGI: 通过遗传相互作用推断
17954568 MGI
involved in negative regulation of mast cell activation involved in immune response IDA
IDA: 通过直接分析推断
10026201 MGI
acts upstream of or within negative regulation of peptidyl-tyrosine phosphorylation IMP
IMP: 通过突变表型推断
9254656 MGI
involved in negative regulation of tumor necrosis factor production IGI
IGI: 通过遗传相互作用推断
17954568 MGI
acts upstream of peptidyl-tyrosine phosphorylation IMP
IMP: 通过突变表型推断
9254656 MGI
acts upstream of or within platelet aggregation IMP
IMP: 通过突变表型推断
23509158 MGI
acts upstream of or within platelet formation IGI
IGI: 通过遗传相互作用推断
23509158 MGI
acts upstream of or within positive regulation of cell adhesion mediated by integrin IMP
IMP: 通过突变表型推断
23509158 MGI
acts upstream of or within protein dephosphorylation IDA
IDA: 通过直接分析推断
8632004 MGI
acts upstream of or within protein dephosphorylation IMP
IMP: 通过突变表型推断
9064344 MGI
acts upstream of or within regulation of B cell differentiation IMP
IMP: 通过突变表型推断
9254656 MGI
acts upstream of or within regulation of release of sequestered calcium ion into cytosol IGI
IGI: 通过遗传相互作用推断
23509253 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of alpha-beta T cell receptor complex IDA
IDA: 通过直接分析推断
9064344 MGI
located in cell-cell junction IDA
IDA: 通过直接分析推断
23793062 MGI
is active in cytoplasm IDA
IDA: 通过直接分析推断
27830702 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tyrosine-protein phosphatase non-receptor type 6

SH2 phosphatase 1

hematopoietic cell protein-tyrosine phosphatase

motheaten

protein-tyrosine phosphatase 1C

重组 Ptpn6 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73649 SHP-1 Protein, Mouse (sf9, His-GST) P29351-2 (A207-K597) ≥95%

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-136657 SC-43 99.01% Phase 2
Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N4150 Quercetagitrin Inhibitor 98.34% 否
HY-RS11429 PTPN6 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17306 Ptpn6 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23761 Ptpn6 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ptpn6 NCBI NCBI:5777
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