2. Gene
  3. Htt - huntingtin Gene

Htt - huntingtin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Hd; Hdh; IT15; C430023I11Rik

基因 ID: 15194 | 基因类型: protein coding

关于 Htt

功能概要

Enables diazepam binding activity. Involved in several processes, including postsynapse to nucleus signaling pathway; regulation of cAMP-dependent protein kinase activity; and regulation of protein localization to nucleus. Acts upstream of or within several processes, including carboxylic acid metabolic process; positive regulation of cilium assembly; and transport along microtubule. Located in several cellular components, including centriole; inclusion body; and perinuclear region of cytoplasm. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; olfactory epithelium; peripheral nervous system; retina; and testis. Used to study Huntington's disease. Human ortholog(s) of this gene implicated in Huntington's disease and Parkinson's disease. Orthologous to human HTT (Huntingtin). [provided by Alliance of Genome Resources, Apr 2022]

Htt 基因产物(1)

mRNA Protein Name
NM_010414.3 NP_034544.1 huntingtin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables diazepam binding IMP
IMP: 通过突变表型推断
10082833 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
9599014 MGI
enables transcription factor binding IPI
IPI: 通过物理相互作用推断
18595722 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within G protein-coupled dopamine receptor signaling pathway IMP
IMP: 通过突变表型推断
17715336 MGI
acts upstream of or within anatomical structure morphogenesis IMP
IMP: 通过突变表型推断
16109169 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: 通过突变表型推断
16109169 MGI
acts upstream of or within associative learning IMP
IMP: 通过突变表型推断
17284197 MGI
acts upstream of or within axo-dendritic transport IMP
IMP: 通过突变表型推断
15340079 MGI
acts upstream of or within brain development IMP
IMP: 通过突变表型推断
16978870 MGI
acts upstream of or within cellular senescence IMP
IMP: 通过突变表型推断
16403806 MGI
acts upstream of or within central nervous system development IMP
IMP: 通过突变表型推断
9398841 MGI
acts upstream of or within citrulline metabolic process IMP
IMP: 通过突变表型推断
17213233 MGI
acts upstream of or within determination of adult lifespan IMP
IMP: 通过突变表型推断
11062468 MGI
acts upstream of or within embryo development IMP
IMP: 通过突变表型推断
9398841 MGI
acts upstream of or within endoplasmic reticulum organization IMP
IMP: 通过突变表型推断
16256944 MGI
acts upstream of or within endoplasmic reticulum to Golgi vesicle-mediated transport IMP
IMP: 通过突变表型推断
11092755 MGI
acts upstream of or within endosomal transport IMP
IMP: 通过突变表型推断
11092755 MGI
acts upstream of or within gastrulation IMP
IMP: 通过突变表型推断
7550343 MGI
acts upstream of or within gene expression IMP
IMP: 通过突变表型推断
30391555 MGI
acts upstream of or within grooming behavior IMP
IMP: 通过突变表型推断
10778856 MGI
acts upstream of or within hormone metabolic process IMP
IMP: 通过突变表型推断
10078572 MGI
acts upstream of or within insulin secretion IMP
IMP: 通过突变表型推断
10078572 MGI
acts upstream of or within lactate biosynthetic process from pyruvate IMP
IMP: 通过突变表型推断
17708681 MGI
acts upstream of or within learning IMP
IMP: 通过突变表型推断
16624677 MGI
acts upstream of or within learning or memory IMP
IMP: 通过突变表型推断
16403806 MGI
acts upstream of or within locomotory behavior IMP
IMP: 通过突变表型推断
7774020 MGI
acts upstream of or within mitochondrial transport IMP
IMP: 通过突变表型推断
15340079 MGI
acts upstream of or within mitochondrion organization IMP
IMP: 通过突变表型推断
11092755 MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis IMP
IMP: 通过突变表型推断
11092755 MGI
acts upstream of or within negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
15242649 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
7550343 MGI
acts upstream of or within neural plate formation IMP
IMP: 通过突变表型推断
7774020 MGI
acts upstream of or within neurogenesis IMP
IMP: 通过突变表型推断
11062468 MGI
NOT acts upstream of or within neuron development IMP
IMP: 通过突变表型推断
10037472 MGI
acts upstream of or within neuron development IMP
IMP: 通过突变表型推断
7774020 MGI
acts upstream of or within olfactory lobe development IMP
IMP: 通过突变表型推断
12926013 MGI
acts upstream of or within paraxial mesoderm formation IMP
IMP: 通过突变表型推断
16109169 MGI
acts upstream of or within peptide hormone secretion IMP
IMP: 通过突变表型推断
10078572 MGI
acts upstream of or within positive regulation of motile cilium assembly IMP
IMP: 通过突变表型推断
21985783 MGI
acts upstream of or within positive regulation of non-motile cilium assembly IMP
IMP: 通过突变表型推断
21985783 MGI
involved in postsynapse to nucleus signaling pathway IDA
IDA: 通过直接分析推断
20739295 MGI
involved in postsynapse to nucleus signaling pathway IEP
IEP: 通过表达模式推断
20739295 MGI
involved in postsynapse to nucleus signaling pathway IMP
IMP: 通过突变表型推断
20739295 MGI
acts upstream of or within protein localization to centrosome IMP
IMP: 通过突变表型推断
21985783 MGI
acts upstream of or within protein localization to nucleus IMP
IMP: 通过突变表型推断
11092755 MGI
acts upstream of or within quinolinate biosynthetic process IMP
IMP: 通过突变表型推断
16697652 MGI
involved in regulation of cAMP-dependent protein kinase activity IMP
IMP: 通过突变表型推断
21768291 MGI
involved in regulation of gene expression IMP
IMP: 通过突变表型推断
21768291 MGI
involved in regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
21768291 MGI
involved in regulation of protein localization to nucleus IMP
IMP: 通过突变表型推断
21768291 MGI
acts upstream of or within regulation of synaptic plasticity IMP
IMP: 通过突变表型推断
10196373 MGI
acts upstream of or within response to calcium ion IMP
IMP: 通过突变表型推断
15935052 MGI
acts upstream of or within social behavior IMP
IMP: 通过突变表型推断
10196365 MGI
acts upstream of or within spermatogenesis IMP
IMP: 通过突变表型推断
11062468 MGI
acts upstream of or within striatum development IMP
IMP: 通过突变表型推断
11030759 MGI
acts upstream of or within urea cycle IMP
IMP: 通过突变表型推断
17213233 MGI
acts upstream of or within vesicle transport along microtubule IDA
IDA: 通过直接分析推断
15242649 MGI
acts upstream of or within visual learning IMP
IMP: 通过突变表型推断
7774020 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
8757264 MGI
located in centriole IDA
IDA: 通过直接分析推断
21985783 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
7647777 MGI
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
15242649 MGI
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
25738228 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
20739295 MGI
is active in glutamatergic synapse IEP
IEP: 通过表达模式推断
20739295 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
20739295 MGI
located in inclusion body IDA
IDA: 通过直接分析推断
15615787 MGI
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
25738228 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

huntingtin

HD protein homolog

Huntington disease gene homolog

huntington disease protein homolog

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-132579 Tominersen 94.13% Phase 3
HY-132593 Rovanersen / Phase 2
Pre-clinical Phase
生物活性分子 (17)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-16009 Buntanetap 99.71% 否
HY-156650 Votoplam Modulator 99.51% 否
HY-132579A Tominersen sodium 97.36% 否
HY-136780 SEN177 Inhibitor 98.76% 否
HY-156103 mHTT-IN-2 Inhibitor 99.35% 否
HY-150236 FITC-labeled Tominersen sodium Inhibitor 95.72% 否
HY-132593A Rovanersen sodium 95.58% 否
HY-16009B Buntanetap L-Tartrate 98.93% 否
HY-143792 HTT-D3 Inhibitor / 否
HY-10542A (Z)-GW 5074 Inhibitor / 否
HY-P10822 ED11 Inhibitor / 否
HY-RS06490 HTT Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS13311 SLC6A4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS13312 Slc6a4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-W792458 MADAM Ligand / 否
HY-RS18021 Htt Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24494 Htt Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Htt NCBI NCBI:3064
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