CYP2C8 - cytochrome P450 family 2 subfamily C member 8 Gene

中文名称：细胞色素 P450 家族 2 亚家族 C 成员 8

种属: Homo sapiens

同用名: CPC8; CYPIIC8; CYP2C8DM; MP-12/MP-20

基因 ID: 1558 | 基因类型: protein coding

关于 CYP2C8

Cytogenetic location: 10q23.33 Genomic coordinates (GRCh38): 10:95,036,772-95,069,497 (from NCBI)

This gene has 12 transcripts (splice variants), 30 orthologues, 15 paralogues and is associated with 59 phenotypes. Restricted expression toward liver (RPKM 350.3).

功能概要

该基因编码细胞色素 P450 酶超家族的成员。细胞色素 P450 蛋白是单加氧酶，可催化许多涉及药物代谢和胆固醇、类固醇和其他脂质合成的反应。该蛋白质定位于内质网，其表达由苯巴比妥诱导。已知该酶可代谢许多异生素，包括抗惊厥药物美芬妥英、苯并 (a) 芘、7-乙氧基香豆素和抗癌药物紫杉醇。该基因位于染色体 10q24 上的细胞色素 P450 基因簇内。已发现该基因的几种转录变体编码几种不同的亚型。[RefSeq 提供，2010 年 11 月]

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of Cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

CYP2C8 基因产物(4)

mRNA	Protein	Name
NM_000770.3	NP_000761.3	cytochrome P450 2C8 isoform a precursor
NM_001198853.1	NP_001185782.1	cytochrome P450 2C8 isoform b
NM_001198854.1	NP_001185783.1	cytochrome P450 2C8 isoform c
NM_001198855.1	NP_001185784.1	cytochrome P450 2C8 isoform b

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables arachidonate epoxygenase activity	IDA IDA: 通过直接分析推断	7574697	GOA
enables caffeine oxidase activity	IDA IDA: 通过直接分析推断	18619574	GOA
enables estrogen 16-alpha-hydroxylase activity	IDA IDA: 通过直接分析推断	14559847	GOA
enables monooxygenase activity	IDA IDA: 通过直接分析推断	15766564	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32814053	GOA
enables retinoic acid 4-hydroxylase activity	IDA IDA: 通过直接分析推断	11093772	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in epoxygenase P450 pathway	IDA IDA: 通过直接分析推断	7574697	GOA
involved in estrogen metabolic process	IDA IDA: 通过直接分析推断	12865317	GOA
involved in icosanoid biosynthetic process	IDA IDA: 通过直接分析推断	15766564	GOA
involved in lipid hydroxylation	IDA IDA: 通过直接分析推断	14559847	GOA
involved in organic acid metabolic process	IDA IDA: 通过直接分析推断	19651758	GOA
involved in oxidative demethylation	IDA IDA: 通过直接分析推断	18619574	GOA
involved in retinoic acid metabolic process	IDA IDA: 通过直接分析推断	11093772	GOA
involved in steroid metabolic process	IDA IDA: 通过直接分析推断	14559847	GOA
involved in xenobiotic catabolic process	IDA IDA: 通过直接分析推断	18619574	GOA
involved in xenobiotic metabolic process	IDA IDA: 通过直接分析推断	19651758	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CYP2C8 蛋白结构

p450

0
100
200
300
400
490 a.a.

蛋白主名

其他名称

cytochrome P450 2C8

P450 form 1

关联疾病

疾病名称

别名

Drug Metabolism, Altered, Cyp2c8-Related

{Drug Metabolism, Altered, Cyp2c8-Related}

Osteonecrosis Of The Jaw

Sulfamethoxazole Allergy

Smx Allergy	Smz Allergy
Sulphamethoxazole Allergy

Gout

Gouty Arthritis	Articular Gout
Gouty Arthropathy	Arthritis, Gouty
Arthritis Gouty	Idiopathic Gout
Idiopathic Gout, Unspecified Site	Gouty Bursitis
Uratic Arthritis	Gout Nos
Gouty	Gouty Diathesis

Osteonecrosis

Bone Necrosis	Avascular Necrosis Of Bone
Aseptic Necrosis	Necrosis Of Bone Nos
Aseptic Osteonecrosis	Aseptic Necrosis Of Bone, Site Unspecified
Aseptic Or Avascular Bone Necrosis	Aseptic Necrosis Of Bone
Necrotic Bone	Necrotizing Bone
Spontaneous Osteonecrosis	Osteoradionecrosis

Hypertrophy Of Tongue Papillae

Tongue Papillary Hypertrophy

Hypertrophy Of Foliate Papillae

Smallpox

Variola	Ordinary Smallpox
Alastrim	Amaas

Coumarin Resistance

Warfarin Resistance	Warfarin Sensitivity
Coumadin Sensitivity	Warfarin Response
Poor Metabolism Of Coumarin	Coumarin, Poor Metabolism Of
CMRES

Gilbert Syndrome

Gilbert Disease	Gilbert'S Disease
Gilbert'S Syndrome	Cholemia, Familial
Familial Nonhemolytic Jaundice	Meulengracht Syndrome
Gilbert Syndrome, Susceptibility To	Hyperbilirubinemia, Gilbert Type
Hblrg	Hyperbilirubinemia, Arias Type
Hyperbilirubinemia I	Constitutional Hyperbilirubinemia
Gilbert-Meulengracht Syndrome	Hereditary Nonhemolytic Jaundice
Hyperbilirubinemia Arias Type	Hyperbilirubinemia Type 1
Constitutional Liver Dysfunction	Gilbert-Lereboullet Syndrome
Hyperbilirubinemia 1	Unconjugated Benign Bilirubinemia
GILBS	Gilberts Syndrome
Familial Nonhaemolytic Jaundice	Constitutional Hyperbilirubinaemia
Hereditary Nonhaemolytic Bilirubinaemia	Familial Nonhaemolytic Bilirubinaemia
Idiopathic Hyperbilirubinaemia	Icterus Intermittens Juvenilis
Chronic Intermittent Juvenile Jaundice	Low-Grade Chronic Hyperbilirubinaemia Syndrome
Benign Unconjugated Bilirubinaemia Syndrome	Hereditary Nonhaemolytic Jaundice
Idiopathic Unconjugated Hyperbilirubinaemia	Gilbert--Lereboullet Syndrome
Constitutional Hepatic Dysfunction	Meulengracht Icterus
Cholaemia Familiaris Simplex	Familial Cholaemia
Congenital Familial Cholaemia	Physiologic Cholaemia
Hyperbilirubinaemia Type 1	Gilbert Cholaemia

Bilirubin Metabolic Disorder

Hyperbilirubinemia	Hereditary Hyperbilirubinemia
Hyperbilirubinemia, Hereditary	Hyperbilirubinaemia

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-17356	Fenofibrate		99.97%	是

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-129993	Gemfibrozil 1-O-β-glucuronide	Inhibitor	99.87%	否
HY-N0319	Salvianolic acid C	Inhibitor	99.94%	否
HY-W013268	(S)-(+)-N-3-Benzylnirvanol	Inhibitor	99.54%	否
HY-117026	LKY-047	Inhibitor	99.94%	否
HY-148352	BAY-4931	Antagonist	98.72%	否
HY-114759	MS-PPOH	Inhibitor	99.05%	否
HY-100641	4-Hydroxytolbutamide		99.69%	否
HY-135331	N-Desmethyl-Apalutamide		99.68%	否
HY-100641S	4-Hydroxytolbutamide-d9		99.29%	否
HY-135335	3'-Hydroxy Repaglinide		98.09%	否
HY-70002AS	N-desmethyl Enzalutamide-d6	Antagonist	97.95%	否
HY-17356R	Fenofibrate (Standard)		99.91%	否
HY-135334	ACP-5862	Inhibitor	98.32%	否
HY-163438	BKIDC-1553	Inhibitor	99.65%	否
HY-163996	DD202-114		98.47%	否
HY-116862	Dibenzylfluorescein		99.54%	否
HY-135335S	3'-Hydroxy Repaglinide-d5		99.46%	否
HY-17356S	Fenofibrate-d6		99.70%	否
HY-W754151	N-Desmethyl apalutamide-d4		99.63%	否
HY-135810A	Cletoquine oxalate	Inhibitor	99.63%	否
HY-141530	Clopidogrel-β-D-glucuronide	Inhibitor	/	否
HY-124542	5-Hydroxydiclofenac	Inducer	98.0%	否
HY-135331S	N-Desmethyl-Apalutamide-15N,d4		/	否
HY-135810	Cletoquine	Inhibitor	/	否
HY-135810S	Cletoquine-d4	Inhibitor	/	否
HY-135810S1	Cletoquine-d4-1	Inhibitor	/	否
HY-155376	mTOR inhibitor-14	Inhibitor	/	否
HY-17356G	Fenofibrate (GMP)		/	否
HY-17356S1	Fenofibrate-d4		/	否
HY-RS03459	CYP2C8 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-W699866	Gemfibrozil 1-O-β-glucuronide-d6		/	否
HY-W777442	Cletoquine-d4 Oxalate	Inhibitor	/	否
HY-117160	4-trans-Hydroxy-glibenclamide	Inhibitor	/	否
HY-119311	Ketopioglitazone	Agonist	/	否
HY-135334S	ACP-5862-d4	Inhibitor	/	否
HY-17356S2	Fenofibrate-13C6		/	否
HY-W587878	Thujopsene		/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	CYP2C8	RGD	RGD:1308166

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CYP2C8 - cytochrome P450 family 2 subfamily C member 8 Gene

关于 CYP2C8

功能概要

CYP2C8 基因产物(4)

CYP2C8 蛋白结构

关联疾病

直系同源

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CYP2C8 - cytochrome P450 family 2 subfamily C member 8 Gene

关于 CYP2C8

功能概要

CYP2C8 基因产物(4)

CYP2C8 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z