CYP4A11 - cytochrome P450 family 4 subfamily A member 11 Gene

中文名称：细胞色素 P450 家族 4 亚家族 A 成员 11

种属: Homo sapiens

同用名: CP4Y; CYP4A2; CYP4AII; CYPIVA11

基因 ID: 1579 | 基因类型: protein coding

关于 CYP4A11

Cytogenetic location: 1p33 Genomic coordinates (GRCh38): 1:46,929,188-46,941,476 (from NCBI)

This gene has 8 transcripts (splice variants), 376 orthologues and 12 paralogues. Biased expression in liver (RPKM 280.4) and kidney (RPKM 130.2).

功能概要

该基因编码细胞色素 P450 酶超家族的成员。细胞色素 P450 蛋白是单加氧酶，可催化许多涉及药物代谢和胆固醇、类固醇和其他脂质合成的反应。这种蛋白质定位于内质网并羟基化中链脂肪酸，如月桂酸盐和肉豆蔻酸盐。已发现该基因的多个转录变体。[RefSeq 提供，2016 年 1 月]

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]

CYP4A11 基因产物(3)

mRNA	Protein	Name
NM_000778.4	NP_000769.2	cytochrome P450 4A11 isoform 1
NM_001319155.2	NP_001306084.1	cytochrome P450 4A11 isoform 2
NM_001363587.2	NP_001350516.1	cytochrome P450 4A11 isoform 3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables alkane 1-monooxygenase activity	IDA IDA: 通过直接分析推断	18433732	GOA
enables arachidonate epoxygenase activity	IDA IDA: 通过直接分析推断	9618440	GOA
enables leukotriene-B4 20-monooxygenase activity	IDA IDA: 通过直接分析推断	9799565	GOA
enables long-chain fatty acid omega-hydroxylase activity	IDA IDA: 通过直接分析推断	15145985	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in arachidonate metabolic process	IDA IDA: 通过直接分析推断	10660572	GOA
involved in epoxygenase P450 pathway	IDA IDA: 通过直接分析推断	9618440	GOA
involved in leukotriene metabolic process	IDA IDA: 通过直接分析推断	9799565	GOA
involved in long-chain fatty acid metabolic process	IDA IDA: 通过直接分析推断	18433732	GOA
involved in positive regulation of icosanoid secretion	IMP IMP: 通过突变表型推断	18391101	GOA
involved in pressure natriuresis	IEP IEP: 通过表达模式推断	10660572	GOA
involved in renal water homeostasis	IEP IEP: 通过表达模式推断	10660572	GOA
involved in sodium ion homeostasis	IEP IEP: 通过表达模式推断	10660572	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in apical plasma membrane	IDA IDA: 通过直接分析推断	10660572	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	10660572	GOA
located in intracellular membrane-bounded organelle	IDA IDA: 通过直接分析推断	9618440	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CYP4A11 蛋白结构

p450

0
100
200
300
400
519 a.a.

蛋白主名

其他名称

cytochrome P450 4A11

20-HETE synthase

CYP4A11 抗体

目录号	产品名	应用	反应物种
HY-P82342	Cytochrome P450 4A/CYP4A11 Antibody (YA2087)	WB, IHC-P, IP	Human, Mouse, Rat

关联疾病

疾病名称

别名

Peroxisomal Acyl-Coa Oxidase Deficiency

Pseudoneonatal Adrenoleukodystrophy	Straight-Chain Acyl-Coa Oxidase Deficiency
Pseudoadrenoleukodystrophy	PSEUDO-NALD
Pseudo-Neonatal Adrenoleukodystrophy	Acyl-Coa Oxidase Deficiency
Peroxisomal Acyl-Coenzyme A Oxidase	Acyl-Coenzyme A Oxidase Deficiency
Adrenoleukodystrophy, Pseudoneonatal	Deficiency, Peroxisomal Acyl-Coa Oxidase

Bietti Crystalline Corneoretinal Dystrophy

BCD	Bietti Crystalline Dystrophy
Bietti Tapetoretinal Degeneration With Marginal Corneal Dystrophy	Bietti Crystalline Retinopathy
Bietti'S Crystalline Dystrophy	Crystalline Retinopathy
Dystrophy, Corneoretinal, Crystalline, Bietti

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Gliosarcoma

Glioblastoma With Sarcomatous Component

Sarcomatous Glioblastoma

Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis	Congenital Ichthyosiform Erythroderma
Li	Congenital Nonbullous Ichthyosiform Erythroderma
Arci	Congenital Lamellar Ichthyosis
Nonbullous Congenital Ichthyosiform Erythroderma	Cie
Congenital Non-Bullous Ichthyosiform Erythroderma	Erythrodermic Ichthyosis
Nbcie	Ncie
Non-Bullous Congenital Ichthyosiform Erythroderma	Collodion Baby
Ichthyosis, Lamellar	Non Bullous Congenital Ichthyosiform Erythroderma
Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form	Ichthyosiform Erythroderma, Congenital, Nonbullous, 1
Collodion Baby Syndrome	Ichthyoses, Lamellar
Nbie	Nonbullous Ichthyosiform Erythroderma
Classic Lamellar Ichthyosis	Ichthyosiform Erythroderma Nonbullous Congenital
Ichthyosiform Erythroderma Congenital	Ichthyosis, Congenital, Autosomal Recessive
Ichthyosiform Erythroderma, Congenital	Collodion Fetus
Non-Bullous Ichthyosiform Erythroderma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-156876	20-HETE inhibitor-2	Inhibitor	98.12%	否
HY-151810	TP0472993	Inhibitor	98.22%	否
HY-151809	CYP4A11/CYP4F2-IN-1	Inhibitor	99.82%	否
HY-149770	CYP4A11/CYP4F2-IN-2	Inhibitor	/	否
HY-E70477	Human CYP4A11,Low-Reductase		/	否
HY-E70478	Human CYP4A11,High-Reductase		/	否
HY-RS03476	CYP4A11 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS03478	CYP4F11 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-W472509	11-HETE	Activator	/	否

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CYP4A11 - cytochrome P450 family 4 subfamily A member 11 Gene

关于 CYP4A11

功能概要

CYP4A11 基因产物(3)

CYP4A11 蛋白结构

CYP4A11 抗体

关联疾病

热门区域

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CYP4A11 - cytochrome P450 family 4 subfamily A member 11 Gene

关于 CYP4A11

功能概要

CYP4A11 基因产物(3)

CYP4A11 蛋白结构

CYP4A11 抗体

关联疾病

相关产品

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z