PRUNE2 - prune homolog 2 with BCH domain Gene

中文名称：用 BCH 域修剪同系物 2

种属: Homo sapiens

同用名: BMCC1; BNIPXL; C9orf65; KIAA0367

关于 PRUNE2

功能概要

该基因编码的蛋白质属于 B 细胞 CLL/淋巴瘤 2 和腺病毒 E1B 19 kDa 相互作用家族，其成员在许多细胞过程中发挥作用，包括细胞凋亡、细胞转化和突触功能。这种蛋白质的几种功能已得到证实，包括抑制 Ras 同系物家族成员 A 的活性，从而减少应激纤维的形成和抑制致癌细胞转化。这种蛋白质的高分子量亚型也已显示与衔接蛋白复合物 2、β-适应蛋白和内胚层标记物共定位，表明参与了内吞后贩运。在前列腺癌细胞中，该基因充当肿瘤抑制因子，其表达受前列腺癌抗原 3 调节，前列腺癌抗原 3 是该基因内含子中相对 DNA 链上的非蛋白质编码基因。前列腺癌抗原 3 通过形成双链 RNA 来调节该基因的水平，该双链 RNA 在 RNA 依赖性腺苷到肌苷 RNA 编辑中经历腺苷脱氨酶肌动蛋白。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 7 月]

The protein encoded by this gene belongs to the B-cell CLL/lymphoma 2 and adenovirus E1B 19 kDa interacting family, whose members play roles in many cellular processes including apotosis, cell transformation, and synaptic function. Several functions for this protein have been demonstrated including suppression of Ras homolog family member A activity, which results in reduced stress fiber formation and suppression of oncogenic cellular transformation. A high molecular weight isoform of this protein has also been shown to colocalize with Adaptor protein complex 2, beta-Adaptin and endodermal markers, suggesting an involvement in post-endocytic trafficking. In prostate Cancer cells, this gene acts as a tumor suppressor and its expression is regulated by prostate Cancer antigen 3, a non-protein coding gene on the opposite DNA strand in an intron of this gene. Prostate Cancer antigen 3 regulates levels of this gene through formation of a double-stranded RNA that undergoes Adenosine Deaminase actin on RNA-dependent adenosine-to-inosine RNA editing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]