2. Gene
  3. Idua - iduronidase, alpha-L Gene

Idua - iduronidase, alpha-L Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: 6030426D08

基因 ID: 15932 | 基因类型: protein coding

关于 Idua

功能概要

Enables L-iduronidase activity. Acts upstream of or within several processes, including glycosaminoglycan catabolic process; learning or memory; and skeletal system development. Located in extracellular space. Used to study mucopolysaccharidosis I and otitis media. Human ortholog(s) of this gene implicated in Scheie syndrome; mucopolysaccharidosis I; mucopolysaccharidosis Ih; and mucopolysaccharidosis Ih/s. Orthologous to human IDUA (alpha-L-iduronidase). [provided by Alliance of Genome Resources, Apr 2022]

Idua 基因产物(2)

mRNA Protein Name
NM_008325.4 NP_032351.2 alpha-L-iduronidase isoform 1 precursor
NM_172997.1 NP_766585.1 alpha-L-iduronidase isoform 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables L-iduronidase activity IDA
IDA: 通过直接分析推断
7698753 MGI
enables L-iduronidase activity IMP
IMP: 通过突变表型推断
15979918 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within adult locomotory behavior IMP
IMP: 通过突变表型推断
22580166 MGI
acts upstream of or within adult walking behavior IMP
IMP: 通过突变表型推断
22580166 MGI
acts upstream of or within bone development IMP
IMP: 通过突变表型推断
19751987 MGI
acts upstream of or within cartilage homeostasis IMP
IMP: 通过突变表型推断
19834056 MGI
acts upstream of or within cell morphogenesis IMP
IMP: 通过突变表型推断
9097952 MGI
acts upstream of or within chemical homeostasis IMP
IMP: 通过突变表型推断
9097952 MGI
acts upstream of or within dermatan sulfate catabolic process IDA
IDA: 通过直接分析推断
19751987 MGI
acts upstream of or within dermatan sulfate catabolic process IMP
IMP: 通过突变表型推断
19751987 MGI
involved in dermatan sulfate catabolic process IMP
IMP: 通过突变表型推断
19751987 MGI
acts upstream of or within extracellular matrix organization IMP
IMP: 通过突变表型推断
25410057 MGI
acts upstream of or within glycosaminoglycan catabolic process IDA
IDA: 通过直接分析推断
16979922 MGI
acts upstream of or within glycosaminoglycan catabolic process IMP
IMP: 通过突变表型推断
16979922 MGI
involved in heparan sulfate proteoglycan catabolic process IMP
IMP: 通过突变表型推断
15979918 MGI
acts upstream of or within heparin catabolic process IDA
IDA: 通过直接分析推断
19751987 MGI
acts upstream of or within heparin catabolic process IMP
IMP: 通过突变表型推断
19751987 MGI
acts upstream of or within limb morphogenesis IMP
IMP: 通过突变表型推断
9097952 MGI
acts upstream of or within locomotory behavior IMP
IMP: 通过突变表型推断
18022143 MGI
acts upstream of or within lysosome organization IMP
IMP: 通过突变表型推断
9097952 MGI
acts upstream of or within memory IMP
IMP: 通过突变表型推断
18022143 MGI
acts upstream of or within negative regulation of cartilage development IMP
IMP: 通过突变表型推断
19834056 MGI
acts upstream of or within negative regulation of secretion of lysosomal enzymes IDA
IDA: 通过直接分析推断
16979922 MGI
acts upstream of or within negative regulation of secretion of lysosomal enzymes IMP
IMP: 通过突变表型推断
16979922 MGI
acts upstream of or within positive regulation of bone resorption IMP
IMP: 通过突变表型推断
19834056 MGI
acts upstream of or within positive regulation of collagen catabolic process IMP
IMP: 通过突变表型推断
19834056 MGI
acts upstream of or within skeletal system morphogenesis IMP
IMP: 通过突变表型推断
9097952 MGI
acts upstream of or within visual learning IMP
IMP: 通过突变表型推断
18022143 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
16979922 MGI
is active in lysosomal lumen IMP
IMP: 通过突变表型推断
9660052 MGI
is active in lysosome IMP
IMP: 通过突变表型推断
19751987 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

alpha-L-iduronidase

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99530 Valanafusp alfa 98.42% Phase 2
Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06546 IDUA Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-W654272 4-Methylumbelliferyl-α-L-iduronide 2-sulfate sodium / 否
HY-RS17959 Idua Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24430 Idua Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P99694 Lepunafusp alfa Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Idua NCBI NCBI:3425
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