2. Gene
  3. SDE2 - SDE2 telomere maintenance homolog Gene

SDE2 - SDE2 telomere maintenance homolog Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SDE2 端粒维护同系物

种属: Homo sapiens

同用名: C1orf55; dJ671D7.1

基因 ID: 163859 | 基因类型: protein coding

关于 SDE2

This gene has 1 transcript (splice variant), 199 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 11.6), thyroid (RPKM 7.7) and 25 other tissues.

功能概要

启用受损的 DNA 结合活性。参与多个过程，包括细胞对紫外线的反应；有丝分裂 G1 DNA 损伤检查点信号；和蛋白质泛素化。位于多种细胞成分中，包括高尔基体；胞质溶胶；和核斑点。 [由基因组资源联盟提供，2022 年 4 月]

Enables damaged DNA binding activity. Involved in several processes, including cellular response to UV; mitotic G1 DNA damage checkpoint signaling; and protein ubiquitination. Located in several cellular components, including Golgi apparatus; cytosol; and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]

SDE2 基因产物(1)

mRNA Protein Name
NM_152608.4 NP_689821.3 replication stress response regulator SDE2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables damaged DNA binding IDA
IDA: 通过直接分析推断
27906959 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
24981860 GOA
enables snoRNA binding IDA
IDA: 通过直接分析推断
34365507 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to UV IDA
IDA: 通过直接分析推断
27906959 GOA
involved in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
IMP: 通过突变表型推断
34365507 GOA
involved in mRNA cis splicing, via spliceosome IMP
IMP: 通过突变表型推断
34365507 GOA
involved in mitotic G1 DNA damage checkpoint signaling IDA
IDA: 通过直接分析推断
27906959 GOA
involved in protein processing IDA
IDA: 通过直接分析推断
27906959 GOA
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
27906959 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
34365507 GOA
located in nucleus IDA
IDA: 通过直接分析推断
27906959 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SDE2 蛋白结构

Telomere_Sde2

Telomere_Sde2: Telomere stability and silencing (64 - 166)

Telomere_Sde2_2

Telomere_Sde2_2: Telomere stability C-terminal (385 - 444)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 451 a.a.
蛋白主名 其他名称

replication stress response regulator SDE2

UPF0667 protein C1orf55

SDE2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SDE2 Q6IQ49 HSPBAP1 Homo sapiens Q96EW2
TAP
24981860
种属内
SDE2 Q6IQ49 HSPBAP1 Homo sapiens Q96EW2
Anti Bait CoIP
24981860
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Meningeal Melanomatosis

Leptomeningeal Melanomatosis
Meningeal Melanoma

Melanoma Of The Leptomeninges

Leptomeningeal Melanoma
Malignant Leptomeningeal Tumor

Malignant Leptomeningeal Tumour

Malignant Tumor Of Leptomeninges

Malignant Tumour Of Leptomeninges

Malignant Leptomeningeal Neoplasm
Junctional Epidermolysis Bullosa

Epidermolysis Bullosa, Junctional

Jeb

Epidermolysis Bullosa Atrophicans

Congenital Junctional Epidermolysis Bullosa

Epidermolysis Bullosa Junctional

Junctional Eb - [Epidermolysis Bullosa]

Jeb - [Junctional Epidermolysis Bullosa]

Lucidolytic Epidermolysis Bullosa
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12586 SDE2 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SDE2 VGNC VGNC:100135
Bos taurus SDE2 VGNC VGNC:34384
Mus musculus SDE2 MGD MGI:2384788
Felis catus SDE2 VGNC VGNC:64948
Rattus norvegicus SDE2 RGD RGD:1305572
Canis familiaris SDE2 VGNC VGNC:45946
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