DDB2 - damage specific DNA binding protein 2 Gene

中文名称：损伤特异性 DNA 结合蛋白 2

种属: Homo sapiens

同用名: XPE; DDBB; UV-DDB2

基因 ID: 1643 | 基因类型: protein coding

关于 DDB2

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:47,214,454-47,239,217 (from NCBI)

This gene has 16 transcripts (splice variants), 190 orthologues and is associated with 60 phenotypes. Ubiquitous expression in skin (RPKM 32.0), esophagus (RPKM 13.6) and 24 other tissues.

功能概要

该基因编码的蛋白质是修复紫外线损伤 DNA 所必需的。该蛋白是参与核苷酸切除修复的异二聚体蛋白复合物的较小亚基，该复合物介导组蛋白 H3 和 H4 的泛素化，从而促进细胞对 DNA 损伤的反应。该亚基似乎是 DNA 结合所必需的。该基因的突变导致着色性干皮病互补组 E，这是一种隐性疾病，其特征是对紫外线的敏感性增加和皮肤癌发展的高易感性，在某些情况下还伴有神经系统异常。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2014 年 7 月]

This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin Cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

DDB2 基因产物(6)

mRNA	Protein	Name
NM_000107.3	NP_000098.1	DNA damage-binding protein 2 isoform WT
NM_001300734.2	NP_001287663.1	DNA damage-binding protein 2 isoform D1
NM_001399874.1	NP_001386803.1	DNA damage-binding protein 2 isoform WT
NM_001399875.1	NP_001386804.1	DNA damage-binding protein 2 isoform WT
NM_001399876.1	NP_001386805.1	DNA damage-binding protein 2 isoform D1
NM_001399878.1	NP_001386807.1	DNA damage-binding protein 2 isoform 3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
contributes to damaged DNA binding	IDA IDA: 通过直接分析推断	22334663	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9418871	GOA
enables protein-containing complex binding	IPI IPI: 通过物理相互作用推断	11564863	GOA
contributes to ubiquitin-protein transferase activity	IDA IDA: 通过直接分析推断	12732143	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage response	EXP EXP: 通过实验结果推断	22118460	GOA
involved in UV-damage excision repair	IDA IDA: 通过直接分析推断	14751237	GOA
involved in cellular response to UV	EXP EXP: 通过实验结果推断	22118460	GOA
involved in nucleotide-excision repair	IDA IDA: 通过直接分析推断	19109893	GOA
involved in protein autoubiquitination	IDA IDA: 通过直接分析推断	12732143	GOA
involved in protein polyubiquitination	IDA IDA: 通过直接分析推断	12732143	GOA
involved in response to UV	IDA IDA: 通过直接分析推断	12732143	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Cul4-RING E3 ubiquitin ligase complex	IMP IMP: 通过突变表型推断	16949367	GOA
part of Cul4A-RING E3 ubiquitin ligase complex	EXP EXP: 通过实验结果推断	22118460	GOA
part of Cul4B-RING E3 ubiquitin ligase complex	IDA IDA: 通过直接分析推断	22334663	GOA
located in nucleus	IDA IDA: 通过直接分析推断	14751237	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	12732143	GOA
is active in site of DNA damage	IDA IDA: 通过直接分析推断	19109893	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DDB2 蛋白结构

WD40

0
100
200
300
400
427 a.a.

蛋白主名

其他名称

DNA damage-binding protein 2

DDB p48 subunit

DDB2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	DDB2	Q92466	XPC	Homo sapiens	Q01831-1	Pull Down	22039351
种属内	DDB2	Q92466	XPC	Homo sapiens	Q01831-1	Anti Tag CoIP	22039351
种属内	DDB2	Q92466	DDB1	Homo sapiens	Q16531	X-Ray Diffraction	19109893
种属内	DDB2	Q92466	DDB1	Homo sapiens	Q16531	Anti Tag CoIP	22039351
种属内	DDB2	Q92466	DDB1	Homo sapiens	Q16531	Anti Tag CoIP	28514442
种属内	DDB2	Q92466	DDB1	Homo sapiens	Q16531	Anti Tag CoIP	33961781
种属内	DDB2	Q92466	DDB1	Homo sapiens	Q16531	Anti Bait CoIP	17041588
种属内	DDB2	Q92466	DDB1	Homo sapiens	Q16531	Anti Bait CoIP	16473935
种属内	DDB2	Q92466	E2F1	Homo sapiens	Q01094	Anti Tag CoIP	9418871
种属内	DDB2	Q92466	E2F1	Homo sapiens	Q01094	Pull Down	9418871
种属内	DDB2	Q92466	CUL4A	Homo sapiens	Q13619	Anti Tag CoIP	28514442
种属内	DDB2	Q92466	CUL4A	Homo sapiens	Q13619	Anti Tag CoIP	33961781
种属内	DDB2	Q92466	CUL4A	Homo sapiens	Q13619	Anti Bait CoIP	16473935
种属内	DDB2	Q92466	CUL4A	Homo sapiens	Q13619	Anti Tag CoIP	26496610

种属间: 跨种属相互作用 种属内: 同种属相互作用

DDB2 抗体

目录号	产品名	应用	反应物种
HY-P82382	DDB2 Antibody (YA2127)	WB, IHC-P, ICC/IF, FC	Human

关联疾病

疾病名称

别名

Xeroderma Pigmentosum, Complementation Group E

Xeroderma Pigmentosum V	Xp5
Xeroderma Pigmentosum, Group E, Ddb-Negative Subtype	Xpe
Xp, Group E	Xeroderma Pigmentosum, Type 5
Xeroderma Pigmentosum Complementation Group E	XP-E
Xp Group E

Xeroderma Pigmentosum Group E

Xeroderma Pigmentosum, Group E	Xeroderma Pigmentosum V
Xp Group E	Xp5
Xpe	Xeroderma Pigmentosum, Complementation Group E

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Skin Carcinoma

Skin Cancer	Carcinoma Of Skin
Ca - Skin Cancer	Cancer Of Skin
Malignant Neoplasm Of Skin	Melanoma And Non-Melanoma Skin Cancer
Skin Cancers	Cancer, Skin

Cockayne Syndrome

Cockayne'S Syndrome	Dwarfism-Retinal Atrophy-Deafness Syndrome
Neill-Dingwall Syndrome	Progeria-Like Syndrome
Progeroid Nanism	Cs

Xeroderma Pigmentosum, Complementation Group C

Xeroderma Pigmentosum, Group C	XPC
Xpcc	Xeroderma Pigmentosum Iii
Xp3	Xeroderma Pigmentosum Group C
Xp Group C	Xp, Group C
Xeroderma Pigmentosum, Type 3	Xeroderma Pigmentosum Complementation Group C
XP-C

Xeroderma Pigmentosum, Complementation Group F

Xeroderma Pigmentosum, Group F	Xeroderma Pigmentosum Vi
Xp6	Xeroderma Pigmentosum, Type F/Cockayne Syndrome
XPF	Xp, Group F
Xeroderma Pigmentosum Group F	Xp Group F
Xeroderma Pigmentosum, Type 6	Xeroderma Pigmentosum Complementation Group F
XP-F	Xeroderma Pigmentosum Type F/Cockayne Syndrome
XPF/CS

Xeroderma Pigmentosum, Complementation Group G

Xeroderma Pigmentosum, Group G	Xeroderma Pigmentosum Vii
Xp7	XPG
Xeroderma Pigmentosum Group G	Xp Group G
Xp, Group G	Xpgc
Xeroderma Pigmentosum, Group G/Cockayne Syndrome	Xeroderma Pigmentosum, Type 7
Xeroderma Pigmentosum Complementation Group G	XP-G
Xp-G/Cs	Xeroderma Pigmentosum Group G/Cockayne Syndrome

Cockayne Syndrome A

Cockayne Syndrome Type 1	Cockayne Syndrome, Type A
Cockayne Syndrome Type I	CSA
Cockayne Syndrome Classic Form	Cockayne Syndrome Classical
Cockayne Syndrome Type A	Ckn1

Uv-Sensitive Syndrome

Uvss	Uv Sensitive Syndrome
Ultraviolet Sensitive Syndrome

Xeroderma Pigmentosum, Complementation Group A

Xeroderma Pigmentosum Group A	Xp1
Xeroderma Pigmentosum, Group A	XPA
Xeroderma Pigmentosum I	Xeroderma Pigmentosum Complementation Group A
Xp Group A	Xp, Group A
Xeroderma Pigmentosum 1	Xeroderma Pigmentosum, Type 1
XP-A

Cockayne Syndrome B

Cockayne Syndrome Type 2	Cockayne Syndrome, Type B
Cockayne Syndrome Type Ii	CSB
Cockayne Syndrome 2	Cockayne Syndrome Type B
Ckn2	Cockayne Syndrome, Type Ii

De Sanctis-Cacchione Syndrome

Xerodermic Idiocy	Xeroderma Pigmentosum With Neurologic Manifestation
DSC	Xerodermic Idiocy Of De Sanctis And Cacchione

Trichothiodystrophy 3, Photosensitive

TTD3	Trichothiodystrophy, Complementation Group A
Ttda	Photosensitive Trichothiodystrophy 3
Trichothiodystrophy Complementation Group A

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Trichothiodystrophy

Ttd	Amish Brittle Hair Syndrome
Bids Syndrome	Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome
Ibids	Pibids
Trichothiodystrophy Syndromes

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03607	DDB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS18473	Ddb2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS24954	Ddb2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	DDB2	VGNC	VGNC:39830
Mus musculus	DDB2	MGD	MGI:1355314
Bos taurus	DDB2	VGNC	VGNC:27942
Felis catus	DDB2	VGNC	VGNC:61387
Rattus norvegicus	DDB2	RGD	RGD:1310164
Others	DDB2	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DDB2 - damage specific DNA binding protein 2 Gene

关于 DDB2

功能概要

DDB2 基因产物(6)

DDB2 蛋白结构

DDB2 蛋白互作信息

DDB2 抗体

关联疾病

直系同源

热门区域

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DDB2 - damage specific DNA binding protein 2 Gene

关于 DDB2

功能概要

DDB2 基因产物(6)

DDB2 蛋白结构

DDB2 蛋白互作信息

DDB2 抗体

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

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Q

S

T

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