Junb - jun B proto-oncogene Gene

中文名称：Jun B 原癌基因

种属: Mus musculus

关于 Junb

功能概要

该基因编码的蛋白可启动 DNA 结合转录激活因子活性、RNA 聚合酶 II 特异性和 RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性。参与 RNA 聚合酶 II 对转录的正调控。作用于几个过程的上游或内部，包括蜕膜化；胚胎发育；和成骨细胞增殖。预测位于核质中。预计是转录因子 AP-1 复合体的一部分。以多种结构表达，包括消化系统；心血管系统;中枢神经系统;泌尿生殖系统；和淋巴系统腺体。用于研究系统性红斑狼疮。与人类 JUNB 同源（JunB 原癌基因，AP-1 转录因子亚基）。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including decidualization; embryo development; and osteoblast proliferation. Predicted to be located in nucleoplasm. Predicted to be part of transcription factor AP-1 complex. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and hemolymphoid system gland. Used to study systemic lupus erythematosus. Orthologous to human JUNB (JunB proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Apr 2022]