2. Others Vitamin D Related/Nuclear Receptor Epigenetics PI3K/Akt/mTOR
  3. Isotope-Labeled Compounds Estrogen Receptor/ERR Histone Methyltransferase Thyroid Hormone Receptor PI3K Akt mTOR Androgen Receptor
  4. 4,4'-Sulfonyldiphenol-d8

4,4'-Sulfonyldiphenol-d8  (Synonyms: Bisphenol S (4,4'-Sulfonyldiphenol)-d8)

目录号: HY-W011927S 纯度: 98.88%
COA 产品使用指南 技术支持

4,4'-Sulfonyldiphenol-d8 (Bisphenol S (4,4'-Sulfonyldiphenol)-d8) 是 4,4'-Sulfonyldiphenol (HY-W011927) 的氘代物。4,4'-Sulfonyldiphenol 是一种 Bisphenol A (HY-18260) 的替代品，常被广泛应用于工业和消费品中。4,4'-Sulfonyldiphenol 是一种雌激素受体 (ER) 激动剂，且能够竞争性结合甲状腺激素受体 (TR)，其对于 TRα 和 TRβ 的 IC50 值分别为 2650 μM 和 2294 μM，从而影响乳腺发育，降低胎儿睾丸中雄激素受体 (AR) 的表达。4,4'-Sulfonyldiphenol 通过上调 EZH2 介导的 PI3K/AKT/mTOR 通路促进胶质母细胞瘤的进展。4,4'-Sulfonyldiphenol 在慢性暴露下可通过上调 JunB 和 Atf3 导致小鼠肝脏显著脂质沉积和血脂异常，低剂量时具有致肥胖作用。4,4'-Sulfonyldiphenol 通过改变肠道微生物组诱发肠道炎症。4,4'-Sulfonyldiphenol 加速斑马鱼胚胎幼虫动脉粥样硬化的进展。

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4,4'-Sulfonyldiphenol-d<sub>8</sub>

4,4'-Sulfonyldiphenol-d8 Chemical Structure

CAS No. : 2483831-28-1

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1 mg ￥1600
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Other Forms of 4,4'-Sulfonyldiphenol-d8:

4,4'-Sulfonyldiphenol-d8 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

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  • 生物活性

  • 纯度 & 产品资料

生物活性

4,4'-Sulfonyldiphenol-d8 (Bisphenol S (4,4'-Sulfonyldiphenol)-d8) is the deuterium labeled 4,4'-Sulfonyldiphenol (HY-W011927).4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone), a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC50 values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

4,4'-Sulfonyldiphenol-d8 相关抗体:
分子量

258.32

Formula

C12H2D8O4S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 98.88%

COA (292 KB) HNMR (166 KB) RP-HPLC (343 KB)

产品使用指南 (1538 KB)

4,4'-Sulfonyldiphenol-d8 相关分类

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Keywords:

4,4'-Sulfonyldiphenol-d82483831-28-1Bisphenol S (4,4'-Sulfonyldiphenol)-d8Isotope-Labeled CompoundsEstrogen Receptor/ERRHistone MethyltransferaseThyroid Hormone ReceptorPI3KAktmTORAndrogen ReceptorTHRPhosphoinositide 3-kinasePKBProtein kinase BMammalian target of RapamycinEstrogen receptorEndocrine disruptorNipple retentionMammary epitheliumTwo hit modelInhibitorinhibitorinhibit

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