Lmx1b - LIM homeobox transcription factor 1 beta Gene

种属: Mus musculus

同用名: Icst; LMX1.1; LMX1.2

关于 Lmx1b

功能概要

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including memory; olfactory behavior; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including Collagen fibril organization; nervous system development; and trabecular meshwork development. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; hemolymphoid system; limb; and limb bud. Used to study nail-patella syndrome. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and nail-patella syndrome. Orthologous to human LMX1B (LIM homeobox transcription factor 1 beta). [provided by Alliance of Genome Resources, Apr 2022]