2. Gene
  3. Mstn - myostatin Gene

Mstn - myostatin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Cmpt; Gdf8

基因 ID: 17700 | 基因类型: protein coding

关于 Mstn

功能概要

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Homozygous knockout mice for this gene exhibit increased muscle mass and bone density, and reduced adiposity. [provided by RefSeq, Jul 2016]

Mstn 基因产物(1)

mRNA Protein Name
NM_010834.3 NP_034964.1 growth/differentiation factor 8 preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables heparin binding IDA
IDA: 通过直接分析推断
19644449 MGI
enables identical protein binding IDA
IDA: 通过直接分析推断
28257634 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12595574 MGI
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
19644449 MGI
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
11459935 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cellular response to dexamethasone stimulus IDA
IDA: 通过直接分析推断
23752591 MGI
involved in myoblast migration involved in skeletal muscle regeneration IMP
IMP: 通过突变表型推断
19406121 MGI
involved in negative regulation of insulin receptor signaling pathway IMP
IMP: 通过突变表型推断
16182246 MGI
involved in negative regulation of kinase activity IMP
IMP: 通过突变表型推断
19357233 MGI
acts upstream of or within negative regulation of skeletal muscle tissue growth IMP
IMP: 通过突变表型推断
18286185 MGI
involved in negative regulation of skeletal muscle tissue growth IMP
IMP: 通过突变表型推断
9139826 MGI
involved in positive regulation of lamellipodium assembly IMP
IMP: 通过突变表型推断
19406121 MGI
involved in positive regulation of macrophage chemotaxis IMP
IMP: 通过突变表型推断
19406121 MGI
involved in skeletal muscle satellite cell differentiation IMP
IMP: 通过突变表型推断
26923583 MGI
involved in skeletal muscle tissue regeneration IMP
IMP: 通过突变表型推断
26923583 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
12595574 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
12595574 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

growth/differentiation factor 8

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08731 MSTN Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18142 Mstn Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24617 Mstn Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mstn NCBI NCBI:2660
Felis catus Mstn NCBI NCBI:101081322
Rattus norvegicus Mstn NCBI NCBI:29152
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