2. Gene
  3. Nedd4 - neural precursor cell expressed, developmentally down-regulated 4 Gene

Nedd4 - neural precursor cell expressed, developmentally down-regulated 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Gm7265; Nedd4a; Nedd4-1; EG639396; KIAA0093; E430025J12Rik

基因 ID: 17999 | 基因类型: protein coding

关于 Nedd4

功能概要

Enables several functions, including ionotropic glutamate receptor binding activity; protein phosphorylated amino acid binding activity; and Sodium Channel Inhibitor activity. Involved in negative regulation of vascular endothelial growth factor receptor signaling pathway and regulation of dendrite morphogenesis. Acts upstream of or within several processes, including cellular protein metabolic process; circulatory system development; and neuromuscular junction development. Located in several cellular components, including cytosol; dendritic spine; and glutamatergic synapse. Part of ubiquitin Ligase complex. Is active in postsynaptic cytosol. Is expressed in several structures, including alimentary system; eye; genitourinary system; limb; and nervous system. Orthologous to human NEDD4 (NEDD4 E3 ubiquitin protein Ligase). [provided by Alliance of Genome Resources, Apr 2022]

Nedd4 基因产物(2)

mRNA Protein Name
NM_001357998.1 NP_001344927.1 E3 ubiquitin-protein ligase NEDD4 isoform 2
NM_010890.4 NP_035020.2 E3 ubiquitin-protein ligase NEDD4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ionotropic glutamate receptor binding IDA
IDA: 通过直接分析推断
25505317 MGI
enables phosphoserine residue binding IDA
IDA: 通过直接分析推断
10037602 MGI
enables phosphothreonine residue binding IDA
IDA: 通过直接分析推断
10037602 MGI
enables proline-rich region binding IPI
IPI: 通过物理相互作用推断
9305852 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10446181 MGI
enables sodium channel inhibitor activity IDA
IDA: 通过直接分析推断
10212229 MGI
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
9182527 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within T cell activation IMP
IMP: 通过突变表型推断
18931680 MGI
acts upstream of or within adaptive immune response IMP
IMP: 通过突变表型推断
18931680 MGI
acts upstream of or within blood vessel morphogenesis IGI
IGI: 通过遗传相互作用推断
20026598 MGI
acts upstream of or within blood vessel morphogenesis IMP
IMP: 通过突变表型推断
20026598 MGI
acts upstream of or within endocardial cushion development IGI
IGI: 通过遗传相互作用推断
20026598 MGI
acts upstream of or within endocardial cushion development IMP
IMP: 通过突变表型推断
20026598 MGI
acts upstream of establishment of localization in cell IDA
IDA: 通过直接分析推断
10212229 MGI
acts upstream of or within negative regulation of sodium ion transport IDA
IDA: 通过直接分析推断
10212229 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
20026598 MGI
involved in negative regulation of vascular endothelial growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
15060076 MGI
acts upstream of or within neuromuscular junction development IMP
IMP: 通过突变表型推断
19345204 MGI
acts upstream of or within outflow tract morphogenesis IGI
IGI: 通过遗传相互作用推断
20026598 MGI
acts upstream of or within outflow tract morphogenesis IMP
IMP: 通过突变表型推断
20026598 MGI
acts upstream of or within positive regulation of protein catabolic process IDA
IDA: 通过直接分析推断
11748237 MGI
acts upstream of or within protein monoubiquitination IDA
IDA: 通过直接分析推断
21920314 MGI
acts upstream of or within protein ubiquitination IDA
IDA: 通过直接分析推断
9182527 MGI
involved in regulation of dendrite morphogenesis IMP
IMP: 通过突变表型推断
20159449 MGI
acts upstream of or within regulation of synapse organization IMP
IMP: 通过突变表型推断
19345204 MGI
acts upstream of sodium ion transport IDA
IDA: 通过直接分析推断
10212229 MGI
acts upstream of or within ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
18931680 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
14973438 MGI
located in cytosol IDA
IDA: 通过直接分析推断
9182527 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
25505317 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
25505317 MGI
located in membrane IDA
IDA: 通过直接分析推断
14973438 MGI
is active in postsynaptic cytosol IDA
IDA: 通过直接分析推断
25505317 MGI
is active in postsynaptic cytosol IMP
IMP: 通过突变表型推断
25505317 MGI
part of ubiquitin ligase complex IPI
IPI: 通过物理相互作用推断
11042109 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

E3 ubiquitin-protein ligase NEDD4

HECT-type E3 ubiquitin transferase NEDD4

neural precursor cell expressed developmentally down-regulated protein 4

neural precursor cell expressed, developmentally down-regulated gene 4a

相关产品

Pre-clinical Phase
生物活性分子 (15)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-110204 Heclin Inhibitor 98.21% 否
HY-134417 NSC2805 Inhibitor 99.42% 否
HY-162809 XMU-MP-9 99.12% 否
HY-110174 NAB2 Degrader 99.69% 否
HY-153178 HECT E3-IN-1 Inhibitor 99.43% 否
HY-N10159 1-Benzyl-I3C 99.68% 否
HY-122046 Amb123203 98.87% 否
HY-174375 NEDD4-IN-1 / 否
HY-174415 ZSH-2117 / 否
HY-RS09179 NEDD4 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09180 NEDD4L Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS17116 Nedd4l Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS17232 Nedd4 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS23561 Nedd4l Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS23685 Nedd4 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nedd4 NCBI NCBI:4734
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