2. PROTAC Protein Tyrosine Kinase/RTK JAK/STAT Signaling PI3K/Akt/mTOR Stem Cell/Wnt MAPK/ERK Pathway
  3. PROTACs EGFR Akt ERK
  4. ZSH-2117

ZSH-2117 是一种共价选择性 EGFR PROTAC 降解剂，在 Ba/F3-EGFRL858R/T790M/C797S 细胞中的 DC50 为 45 nM。ZSH-2117 显著抑制细胞增殖，并降低下游 EGFR 信号通路的 AKT 和 ERK 蛋白水平。ZSH-2117 有效抑制 Ba/F3-EGFRL858R/T790M/C797S 异种移植小鼠模型中的肿瘤生长。粉色：EGFR ligand (HY-175162)；蓝色：NEDD4 ligase ligand (HY-175159)；黑色：linker

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ZSH-2117 Chemical Structure

ZSH-2117 Chemical Structure

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ZSH-2117 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

查看 Akt 亚型特异性产品:

查看所有亚型
Akt Akt1 Akt2 Akt3

查看 ERK 亚型特异性产品:

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ERK ERK1 ERK2 ERK5 ERK8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ZSH-2117 is a covalent and selective EGFR PROTAC degrader with a DC50 of 45 nM in Ba/F3-EGFRL858R/T790M/C797S cells. ZSH-2117 significantly inhibits cell proliferation and reduces the downstream EGFR signaling proteins level of AKT and ERK. ZSH-2117 effectively inhibits tumor growth in Ba/F3-EGFRL858R/T790M/C797S xenograft mice model[1]. Pink: EGFR ligand (HY-175162); Blue: NEDD4 ligase ligand (HY-175159); Black: linker

分子量

762.08

Formula

C36H39BrClN8O2P
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ZSH-2117 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZSH-2117ZSH2117ZSH 2117PROTACsEGFRAktERKEpidermal growth factor receptorErbB-1HER1PKBProtein kinase BExtracellular signal regulated kinasesInhibitorsAntitumorBa/F3-EGFRL858R/T790M/C797S cellsBa/F3-EGFRL858R/T790M/C797S xenograft mice modelInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-174415
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