2. Gene
  3. Nf1 - neurofibromin 1 Gene

Nf1 - neurofibromin 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Dsk9; Nf-1; Mhdadsk9; E030030H24Rik

基因 ID: 18015 | 基因类型: protein coding

关于 Nf1

功能概要

Enables GTPase activator activity. Involved in negative regulation of fibroblast proliferation. Acts upstream of or within several processes, including animal organ development; modulation of chemical synaptic transmission; and nervous system development. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and integumental system. Used to study juvenile myelomonocytic leukemia and neurofibromatosis. Human ortholog(s) of this gene implicated in autistic disorder; hematologic Cancer (multiple); nervous system Cancer (multiple); neurofibromatosis 1; and neurofibromatosis-Noonan syndrome. Orthologous to human NF1 (neurofibromin 1). [provided by Alliance of Genome Resources, Apr 2022]

Nf1 基因产物(1)

mRNA Protein Name
NM_010897.2 NP_035027.1 neurofibromin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activator activity IGI
IGI: 通过遗传相互作用推断
15665300 MGI
enables GTPase activator activity IMP
IMP: 通过突变表型推断
8563750 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16405917 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of MAPK cascade IMP
IMP: 通过突变表型推断
16644864 MGI
acts upstream of or within MAPK cascade IMP
IMP: 通过突变表型推断
14724565 MGI
acts upstream of Rac protein signal transduction IGI
IGI: 通过遗传相互作用推断
15665300 MGI
acts upstream of Ras protein signal transduction IGI
IGI: 通过遗传相互作用推断
15665300 MGI
acts upstream of or within Ras protein signal transduction IGI
IGI: 通过遗传相互作用推断
10845775 MGI
acts upstream of Ras protein signal transduction IMP
IMP: 通过突变表型推断
11246230 MGI
acts upstream of or within Ras protein signal transduction IMP
IMP: 通过突变表型推断
8563750 MGI
acts upstream of or within Schwann cell development IMP
IMP: 通过突变表型推断
9001241 MGI
acts upstream of Schwann cell migration IGI
IGI: 通过遗传相互作用推断
14724565 MGI
acts upstream of Schwann cell migration IMP
IMP: 通过突变表型推断
14724565 MGI
acts upstream of Schwann cell proliferation IGI
IGI: 通过遗传相互作用推断
9001241 MGI
acts upstream of Schwann cell proliferation IMP
IMP: 通过突变表型推断
9001241 MGI
acts upstream of or within actin cytoskeleton organization IGI
IGI: 通过遗传相互作用推断
15665300 MGI
acts upstream of or within actin cytoskeleton organization IMP
IMP: 通过突变表型推断
16405917 MGI
acts upstream of or within adrenal gland development IMP
IMP: 通过突变表型推断
16906226 MGI
acts upstream of or within amygdala development IGI
IGI: 通过遗传相互作用推断
25242307 MGI
acts upstream of angiogenesis IGI
IGI: 通过遗传相互作用推断
16648142 MGI
acts upstream of apoptotic process IMP
IMP: 通过突变表型推断
15944386 MGI
acts upstream of or within artery morphogenesis IMP
IMP: 通过突变表型推断
7926784 MGI
acts upstream of astrocyte differentiation IMP
IMP: 通过突变表型推断
9878702 MGI
acts upstream of or within brain development IMP
IMP: 通过突变表型推断
10419687 MGI
acts upstream of or within camera-type eye morphogenesis IMP
IMP: 通过突变表型推断
7926784 MGI
acts upstream of or within cell communication IMP
IMP: 通过突变表型推断
10442636 MGI
acts upstream of cell migration IGI
IGI: 通过遗传相互作用推断
14724565 MGI
acts upstream of cell migration IMP
IMP: 通过突变表型推断
14724565 MGI
acts upstream of cell population proliferation IGI
IGI: 通过遗传相互作用推断
9001241 MGI
acts upstream of cell population proliferation IMP
IMP: 通过突变表型推断
8563750 MGI
acts upstream of or within cellular response to heat IDA
IDA: 通过直接分析推断
20661302 MGI
acts upstream of or within cerebral cortex development IMP
IMP: 通过突变表型推断
11297510 MGI
acts upstream of or within collagen fibril organization IMP
IMP: 通过突变表型推断
10383727 MGI
acts upstream of endothelial cell proliferation IGI
IGI: 通过遗传相互作用推断
16644864 MGI
acts upstream of endothelial cell proliferation IMP
IMP: 通过突变表型推断
16288202 MGI
acts upstream of or within extracellular matrix organization IMP
IMP: 通过突变表型推断
16835260 MGI
acts upstream of extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: 通过突变表型推断
15039234 MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors IGI
IGI: 通过遗传相互作用推断
15039234 MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors IMP
IMP: 通过突变表型推断
15039234 MGI
acts upstream of fibroblast proliferation IMP
IMP: 通过突变表型推断
10383727 MGI
acts upstream of or within forebrain astrocyte development IMP
IMP: 通过突变表型推断
15944386 MGI
acts upstream of or within forebrain morphogenesis IMP
IMP: 通过突变表型推断
11297510 MGI
acts upstream of or within gamma-aminobutyric acid secretion, neurotransmission IGI
IGI: 通过遗传相互作用推断
25242307 MGI
acts upstream of glial cell proliferation IGI
IGI: 通过遗传相互作用推断
10973261 MGI
acts upstream of glial cell proliferation IMP
IMP: 通过突变表型推断
10442636 MGI
acts upstream of or within glutamate secretion, neurotransmission IGI
IGI: 通过遗传相互作用推断
25242307 MGI
acts upstream of or within hair follicle maturation IMP
IMP: 通过突变表型推断
25340873 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
7920653 MGI
acts upstream of leukocyte apoptotic process IMP
IMP: 通过突变表型推断
17053831 MGI
acts upstream of or within liver development IMP
IMP: 通过突变表型推断
7926784 MGI
acts upstream of or within long-term synaptic potentiation IGI
IGI: 通过遗传相互作用推断
16271875 MGI
acts upstream of or within long-term synaptic potentiation IMP
IMP: 通过突变表型推断
16271875 MGI
acts upstream of mast cell apoptotic process IGI
IGI: 通过遗传相互作用推断
15039234 MGI
acts upstream of mast cell proliferation IGI
IGI: 通过遗传相互作用推断
10620616 MGI
acts upstream of or within metanephros development IMP
IMP: 通过突变表型推断
7926784 MGI
acts upstream of or within myelination in peripheral nervous system IMP
IMP: 通过突变表型推断
10586246 MGI
acts upstream of myeloid cell apoptotic process IMP
IMP: 通过突变表型推断
17053831 MGI
acts upstream of myeloid leukocyte migration IGI
IGI: 通过遗传相互作用推断
17053831 MGI
acts upstream of or within negative regulation of MAP kinase activity IGI
IGI: 通过遗传相互作用推断
10620616 MGI
acts upstream of or within negative regulation of MAP kinase activity IMP
IMP: 通过突变表型推断
11297510 MGI
acts upstream of or within negative regulation of MAPK cascade IMP
IMP: 通过突变表型推断
16644864 MGI
acts upstream of or within negative regulation of Rac protein signal transduction IGI
IGI: 通过遗传相互作用推断
15665300 MGI
acts upstream of or within negative regulation of Ras protein signal transduction IGI
IGI: 通过遗传相互作用推断
15665300 MGI
acts upstream of or within negative regulation of Ras protein signal transduction IMP
IMP: 通过突变表型推断
11246230 MGI
acts upstream of or within negative regulation of Schwann cell migration IGI
IGI: 通过遗传相互作用推断
14724565 MGI
acts upstream of or within negative regulation of Schwann cell migration IMP
IMP: 通过突变表型推断
14724565 MGI
acts upstream of or within negative regulation of Schwann cell proliferation IGI
IGI: 通过遗传相互作用推断
9001241 MGI
acts upstream of or within negative regulation of Schwann cell proliferation IMP
IMP: 通过突变表型推断
9001241 MGI
acts upstream of or within negative regulation of angiogenesis IGI
IGI: 通过遗传相互作用推断
16648142 MGI
acts upstream of or within negative regulation of astrocyte differentiation IMP
IMP: 通过突变表型推断
9878702 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
10591652 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
8563750 MGI
acts upstream of or within negative regulation of cell-matrix adhesion IGI
IGI: 通过遗传相互作用推断
17053831 MGI
acts upstream of or within negative regulation of endothelial cell proliferation IMP
IMP: 通过突变表型推断
16288202 MGI
acts upstream of or within negative regulation of fibroblast proliferation IMP
IMP: 通过突变表型推断
10383727 MGI
involved in negative regulation of fibroblast proliferation IMP
IMP: 通过突变表型推断
20154697 MGI
acts upstream of or within negative regulation of glial cell proliferation IGI
IGI: 通过遗传相互作用推断
10973261 MGI
acts upstream of or within negative regulation of glial cell proliferation IMP
IMP: 通过突变表型推断
10442636 MGI
acts upstream of or within negative regulation of leukocyte migration IGI
IGI: 通过遗传相互作用推断
17053831 MGI
acts upstream of or within negative regulation of mast cell proliferation IGI
IGI: 通过遗传相互作用推断
10620616 MGI
acts upstream of or within negative regulation of neuroblast proliferation IMP
IMP: 通过突变表型推断
7926784 MGI
acts upstream of or within negative regulation of neurotransmitter secretion IGI
IGI: 通过遗传相互作用推断
16298082 MGI
acts upstream of or within negative regulation of neurotransmitter secretion IMP
IMP: 通过突变表型推断
16298082 MGI
acts upstream of or within negative regulation of oligodendrocyte differentiation IMP
IMP: 通过突变表型推断
15944386 MGI
acts upstream of or within negative regulation of osteoclast differentiation IGI
IGI: 通过遗传相互作用推断
17053831 MGI
acts upstream of or within negative regulation of protein import into nucleus IMP
IMP: 通过突变表型推断
12469121 MGI
acts upstream of or within negative regulation of protein kinase activity IGI
IGI: 通过遗传相互作用推断
17053831 MGI
acts upstream of or within negative regulation of protein kinase activity IMP
IMP: 通过突变表型推断
16835260 MGI
acts upstream of or within negative regulation of stem cell proliferation IGI
IGI: 通过遗传相互作用推断
10591653 MGI
acts upstream of or within negative regulation of vascular associated smooth muscle cell migration IGI
IGI: 通过遗传相互作用推断
16644864 MGI
acts upstream of or within neural tube development IGI
IGI: 通过遗传相互作用推断
10419687 MGI
acts upstream of neuroblast proliferation IMP
IMP: 通过突变表型推断
7926784 MGI
acts upstream of neuron apoptotic process IGI
IGI: 通过遗传相互作用推断
10845775 MGI
acts upstream of neuron apoptotic process IMP
IMP: 通过突变表型推断
7671302 MGI
acts upstream of neurotransmitter secretion IGI
IGI: 通过遗传相互作用推断
16298082 MGI
acts upstream of neurotransmitter secretion IMP
IMP: 通过突变表型推断
16298082 MGI
acts upstream of or within observational learning IGI
IGI: 通过遗传相互作用推断
25242307 MGI
acts upstream of oligodendrocyte differentiation IMP
IMP: 通过突变表型推断
15944386 MGI
acts upstream of or within osteoblast differentiation IMP
IMP: 通过突变表型推断
16893911 MGI
acts upstream of osteoclast differentiation IGI
IGI: 通过遗传相互作用推断
17053831 MGI
acts upstream of or within peripheral nervous system development IMP
IMP: 通过突变表型推断
10419687 MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
14724565 MGI
acts upstream of or within pigmentation IGI
IGI: 通过遗传相互作用推断
10620616 MGI
acts upstream of or within pigmentation IMP
IMP: 通过突变表型推断
10594763 MGI
acts upstream of or within positive regulation of GTPase activity IMP
IMP: 通过突变表型推断
8563750 MGI
acts upstream of or within positive regulation of adenylate cyclase activity IMP
IMP: 通过突变表型推断
11788835 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
15944386 MGI
acts upstream of or within positive regulation of endothelial cell proliferation IGI
IGI: 通过遗传相互作用推断
16644864 MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: 通过突变表型推断
15039234 MGI
acts upstream of or within positive regulation of leukocyte apoptotic process IMP
IMP: 通过突变表型推断
17053831 MGI
acts upstream of or within positive regulation of mast cell apoptotic process IGI
IGI: 通过遗传相互作用推断
15039234 MGI
acts upstream of or within positive regulation of myeloid cell apoptotic process IMP
IMP: 通过突变表型推断
17053831 MGI
acts upstream of or within positive regulation of neuron apoptotic process IGI
IGI: 通过遗传相互作用推断
10845775 MGI
acts upstream of or within positive regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
7671302 MGI
acts upstream of or within positive regulation of vascular associated smooth muscle cell proliferation IGI
IGI: 通过遗传相互作用推断
16644864 MGI
acts upstream of protein import into nucleus IMP
IMP: 通过突变表型推断
12469121 MGI
acts upstream of or within regulation of ERK1 and ERK2 cascade IGI
IGI: 通过遗传相互作用推断
16271875 MGI
acts upstream of or within regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
16271875 MGI
acts upstream of or within regulation of MAPK cascade IGI
IGI: 通过遗传相互作用推断
25242307 MGI
acts upstream of or within regulation of angiogenesis IMP
IMP: 通过突变表型推断
16288202 MGI
acts upstream of or within regulation of bone resorption IMP
IMP: 通过突变表型推断
17053831 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
10678181 MGI
acts upstream of or within regulation of cell-matrix adhesion IMP
IMP: 通过突变表型推断
16405917 MGI
acts upstream of or within regulation of gene expression IGI
IGI: 通过遗传相互作用推断
25242307 MGI
acts upstream of or within regulation of glial cell differentiation IMP
IMP: 通过突变表型推断
12904481 MGI
acts upstream of or within regulation of long-term neuronal synaptic plasticity IGI
IGI: 通过遗传相互作用推断
11793011 MGI
acts upstream of or within regulation of long-term neuronal synaptic plasticity IMP
IMP: 通过突变表型推断
11793011 MGI
acts upstream of or within regulation of long-term synaptic potentiation IGI
IGI: 通过遗传相互作用推断
25242307 MGI
involved in regulation of postsynapse organization IDA
IDA: 通过直接分析推断
22105171 MGI
involved in regulation of postsynapse organization IMP
IMP: 通过突变表型推断
22105171 MGI
acts upstream of or within regulation of synaptic transmission, GABAergic IGI
IGI: 通过遗传相互作用推断
11793011 MGI
acts upstream of or within response to hypoxia IMP
IMP: 通过突变表型推断
16288202 MGI
acts upstream of or within skeletal muscle tissue development IMP
IMP: 通过突变表型推断
7926784 MGI
acts upstream of or within smooth muscle tissue development IMP
IMP: 通过突变表型推断
7926784 MGI
acts upstream of or within spinal cord development IMP
IMP: 通过突变表型推断
16906226 MGI
acts upstream of stem cell proliferation IGI
IGI: 通过遗传相互作用推断
10591653 MGI
acts upstream of or within sympathetic nervous system development IMP
IMP: 通过突变表型推断
7926784 MGI
acts upstream of vascular associated smooth muscle cell migration IGI
IGI: 通过遗传相互作用推断
16644864 MGI
acts upstream of vascular associated smooth muscle cell proliferation IGI
IGI: 通过遗传相互作用推断
16644864 MGI
acts upstream of or within visual learning IGI
IGI: 通过遗传相互作用推断
9054942 MGI
acts upstream of or within visual learning IMP
IMP: 通过突变表型推断
11793011 MGI
acts upstream of or within wound healing IMP
IMP: 通过突变表型推断
10383727 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
15133494 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
22105171 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
22105171 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

neurofibromin

neurofibromatosis 1

neurofibromatosis-related protein NF-1

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-158115 NST-628 Inhibitor 98.61% 否
HY-113821 1-Naphthyl phosphate potassium salt Inhibitor / 否
HY-RS09233 NF1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-120614 BMS-186511 Inhibitor / 否
HY-156872 MTX-216 / 否
HY-RS17398 Nf1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23853 Nf1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nf1 NCBI NCBI:4763
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