2. Gene
  3. Nfkbia - nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Gene

Nfkbia - nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Nfkbi

基因 ID: 18035 | 基因类型: protein coding

关于 Nfkbia

功能概要

Predicted to enable several functions, including NF-kappaB binding activity; nuclear localization sequence binding activity; and ubiquitin protein Ligase binding activity. Acts upstream of or within several processes, including lipopolysaccharide-mediated signaling pathway; negative regulation of Notch signaling pathway; and pattern recognition receptor signaling pathway. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; naris; and vibrissa follicle. Used to study Sjogren's syndrome and atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including childhood-onset asthma; hematologic Cancer (multiple); hepatitis B; hepatitis C; and lung disease (multiple). Orthologous to human NFKBIA (NFKB inhibitor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Nfkbia 基因产物(1)

mRNA Protein Name
NM_010907.2 NP_035037.2 NF-kappa-B inhibitor alpha
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
9223278 MGI
enables transcription regulator inhibitor activity IDA
IDA: 通过直接分析推断
7963540 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in B cell receptor signaling pathway IDA
IDA: 通过直接分析推断
17367755 MGI
acts upstream of Notch signaling pathway IMP
IMP: 通过突变表型推断
15845452 MGI
acts upstream of or within cellular response to biotic stimulus IDA
IDA: 通过直接分析推断
23262141 MGI
acts upstream of or within cellular response to tumor necrosis factor IDA
IDA: 通过直接分析推断
24349514 MGI
acts upstream of or within lipopolysaccharide-mediated signaling pathway IDA
IDA: 通过直接分析推断
12872135 MGI
acts upstream of or within negative regulation of Notch signaling pathway IMP
IMP: 通过突变表型推断
15845452 MGI
involved in negative regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
7963540 MGI
acts upstream of or within negative regulation of myeloid cell differentiation IMP
IMP: 通过突变表型推断
15845452 MGI
acts upstream of or within nucleotide-binding oligomerization domain containing 1 signaling pathway IDA
IDA: 通过直接分析推断
18261938 MGI
acts upstream of or within nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
IDA: 通过直接分析推断
18261938 MGI
acts upstream of or within positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
18505784 MGI
involved in positive regulation of transcription initiation by RNA polymerase II IMP
IMP: 通过突变表型推断
16322095 MGI
acts upstream of or within protein import into nucleus IDA
IDA: 通过直接分析推断
11799106 MGI
acts upstream of or within regulation of cell population proliferation IDA
IDA: 通过直接分析推断
11799106 MGI
acts upstream of or within regulation of gene expression IMP
IMP: 通过突变表型推断
21737317 MGI
acts upstream of or within response to exogenous dsRNA IDA
IDA: 通过直接分析推断
12872135 MGI
acts upstream of or within response to lipopolysaccharide IDA
IDA: 通过直接分析推断
12872135 MGI
acts upstream of or within response to muramyl dipeptide IDA
IDA: 通过直接分析推断
15692051 MGI
acts upstream of or within response to muscle stretch IDA
IDA: 通过直接分析推断
20442316 MGI
acts upstream of or within toll-like receptor 4 signaling pathway IDA
IDA: 通过直接分析推断
18261938 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11799106 MGI
located in cytosol IDA
IDA: 通过直接分析推断
11799106 MGI
located in nucleus IDA
IDA: 通过直接分析推断
11799106 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

NF-kappa-B inhibitor alpha

I(Kappa)B(alpha)

I-kappa-B-alpha

I-kappaBalpha

ikB-alpha

ikappaBalpha

nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha

nuclear factor of kappa light polyp gene enhancer in B-cell 1

Nfkbia 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Nfkbia Q9Z1E3 Relb Mus musculus Q04863
Anti Bait CoIP
23086447
种属内
Nfkbia Q9Z1E3 Rela Mus musculus Q04207
Anti Bait CoIP
20634424
种属内
Nfkbia Q9Z1E3 Rela Mus musculus Q04207
Anti Bait CoIP
23850221
种属内
Nfkbia Q9Z1E3 Rela Mus musculus Q04207
Anti Bait CoIP
23086447
种属内
Nfkbia Q9Z1E3 Rela Mus musculus Q04207
Anti Bait CoIP
18401342
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09260 NFKBIA Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18565 Nfkbia Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25048 Nfkbia Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nfkbia NCBI NCBI:4792
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