Ntrk1 - neurotrophic tyrosine kinase, receptor, type 1 Gene

中文名称：神经营养性酪氨酸激酶，受体，1 型

种属: Mus musculus

同用名: Tkr; trk; TrkA

关于 Ntrk1

功能概要

预计该基因编码的蛋白具有多种功能，包括 GPI 相关肝配蛋白受体活性；神经生长因子结合活性；和神经生长因子受体活性。参与参与神经支配的轴突发生；神经元凋亡过程的负调控；和交感神经系统发育。在几个过程的上游或内部起作用，包括对福尔马林引起的疼痛的行为反应；神经生长因子信号通路；和神经系统发育。位于轴突；细胞表面；和核内体。以多种结构表达，包括鳃弓；性腺;神经系统;感觉器官；和泌尿生殖嵴。用于研究遗传性感觉神经病。该基因的人类直系同源物与阿尔茨海默病有关；遗传性感觉神经病； 4 型遗传性感觉神经病；和精神分裂症。与人类 NTRK1（神经营养受体酪氨酸激酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including GPI-linked Ephrin Receptor activity; nerve growth factor binding activity; and nerve growth factor receptor activity. Involved in axonogenesis involved in innervation; negative regulation of neuron apoptotic process; and sympathetic nervous system development. Acts upstream of or within several processes, including behavioral response to formalin induced pain; nerve growth factor signaling pathway; and nervous system development. Located in axon; cell surface; and endosome. Is expressed in several structures, including branchial arch; gonad; nervous system; sensory organ; and urogenital ridge. Used to study hereditary sensory neuropathy. Human ortholog(s) of this gene implicated in Alzheimer's disease; hereditary sensory neuropathy; hereditary sensory neuropathy type 4; and schizophrenia. Orthologous to human NTRK1 (neurotrophic receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]