2. Gene
  3. Pln - phospholamban Gene

Pln - phospholamban Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Plb

基因 ID: 18821 | 基因类型: protein coding

关于 Pln

功能概要

Enables protein homodimerization activity. Involved in negative regulation of calcium ion import into sarcoplasmic reticulum. Acts upstream of or within several processes, including negative regulation of calcium ion binding activity; regulation of calcium ion transport; and regulation of heart contraction. Located in sarcoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; ear; heart; nervous system; and skeleton. Used to study centronuclear myopathy and dilated cardiomyopathy 1P. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1P and hypertrophic cardiomyopathy 18. Orthologous to human PLN (phospholamban). [provided by Alliance of Genome Resources, Apr 2022]

Pln 基因产物(2)

mRNA Protein Name
NM_001141927.1 NP_001135399.1 cardiac phospholamban
NM_023129.5 NP_075618.1 cardiac phospholamban
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATPase inhibitor activity IDA
IDA: 通过直接分析推断
22971924 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
15201433 MGI
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
30299255 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Notch signaling pathway IDA
IDA: 通过直接分析推断
23117660 MGI
involved in acrosome assembly IDA
IDA: 通过直接分析推断
30733280 MGI
acts upstream of or within adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process IMP
IMP: 通过突变表型推断
10471356 MGI
acts upstream of or within cardiac muscle tissue development IGI
IGI: 通过遗传相互作用推断
10555147 MGI
involved in circadian sleep/wake cycle, sleep IMP
IMP: 通过突变表型推断
38493225 MGI
involved in intracellular calcium ion homeostasis IDA
IDA: 通过直接分析推断
30733280 MGI
acts upstream of or within intracellular calcium ion homeostasis IGI
IGI: 通过遗传相互作用推断
10555147 MGI
involved in locomotor rhythm IMP
IMP: 通过突变表型推断
38493225 MGI
acts upstream of or within muscle cell cellular homeostasis IGI
IGI: 通过遗传相互作用推断
10555147 MGI
acts upstream of or within negative regulation of ATPase-coupled calcium transmembrane transporter activity IDA
IDA: 通过直接分析推断
27923914 MGI
involved in negative regulation of ATPase-coupled calcium transmembrane transporter activity IMP
IMP: 通过突变表型推断
30299255 MGI
acts upstream of or within negative regulation of calcium ion binding IDA
IDA: 通过直接分析推断
27923914 MGI
involved in negative regulation of calcium ion import into sarcoplasmic reticulum IMP
IMP: 通过突变表型推断
30299255 MGI
acts upstream of or within negative regulation of heart contraction IGI
IGI: 通过遗传相互作用推断
10555147 MGI
acts upstream of or within negative regulation of heart contraction IMP
IMP: 通过突变表型推断
8062415 MGI
acts upstream of or within regulation of calcium ion import IMP
IMP: 通过突变表型推断
8620604 MGI
acts upstream of or within regulation of cardiac muscle cell contraction IMP
IMP: 通过突变表型推断
8620604 MGI
acts upstream of or within regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IMP
IMP: 通过突变表型推断
8831698 MGI
acts upstream of or within regulation of heart contraction IMP
IMP: 通过突变表型推断
8831698 MGI
acts upstream of or within regulation of relaxation of muscle IMP
IMP: 通过突变表型推断
10024311 MGI
acts upstream of or within regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IMP
IMP: 通过突变表型推断
9118481 MGI
acts upstream of or within regulation of ryanodine-sensitive calcium-release channel activity IMP
IMP: 通过突变表型推断
10603936 MGI
acts upstream of or within regulation of the force of heart contraction IGI
IGI: 通过遗传相互作用推断
10555147 MGI
acts upstream of or within regulation of the force of heart contraction IMP
IMP: 通过突变表型推断
9118481 MGI
acts upstream of or within regulation of the force of heart contraction by cardiac conduction IMP
IMP: 通过突变表型推断
10644605 MGI
involved in spermatogenesis IDA
IDA: 通过直接分析推断
30733280 MGI
involved in visual learning IMP
IMP: 通过突变表型推断
38493225 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
30733280 MGI
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
27923914 MGI
located in sarcoplasmic reticulum IDA
IDA: 通过直接分析推断
9038922 MGI
located in sarcoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
26816378 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cardiac phospholamban

Pln 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Pln P61014 CAMK2D Homo sapiens Q13557
Pull Down
32873725
种属间
Pln P61014 CAMK2D Homo sapiens Q13557
Protein Kinase Assay
32873725
种属间
Pln P61014 YWHAG Homo sapiens P61981
Pull Down
32873725
种属内
Pln P61014 Prkaca Mus musculus P05132
Protein Kinase Assay
32873725
种属内
Pln P61014 Prkaca Mus musculus P05132
Pull Down
32873725
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-137561 Bexotegrast Inhibitor 99.67% 否
HY-47888 PLN-1474 Inhibitor 99.35% 否
HY-137561A Bexotegrast hydrochloride Inhibitor / 否
HY-RS10727 PLN Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17361 Pln Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23815 Pln Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pln NCBI NCBI:5350
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