2. Gene
  3. Pml - promyelocytic leukemia Gene

Pml - promyelocytic leukemia Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Trim19; 1200009E24Rik

基因 ID: 18854 | 基因类型: protein coding

关于 Pml

功能概要

Enables SMAD binding activity. Involved in several processes, including defense response to Other organism; regulation of gene expression; and signal transduction by p53 class mediator. Acts upstream of or within several processes, including apoptotic signaling pathway; positive regulation of macromolecule metabolic process; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in PML body; cytosol; and nuclear matrix. Is extrinsic component of endoplasmic reticulum membrane. Colocalizes with heterochromatin. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia and skin Cancer. Orthologous to human PML (PML nuclear body scaffold). [provided by Alliance of Genome Resources, Apr 2022]

Pml 基因产物(3)

mRNA Protein Name
NM_001311088.1 NP_001298017.1 protein PML isoform 3
NM_008884.5 NP_032910.3 protein PML isoform 1
NM_178087.4 NP_835188.2 protein PML isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SMAD binding IDA
IDA: 通过直接分析推断
15356634 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12529400 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP
IMP: 通过突变表型推断
15626733 MGI
acts upstream of or within PML body organization IDA
IDA: 通过直接分析推断
12529400 MGI
acts upstream of or within SMAD protein signal transduction IMP
IMP: 通过突变表型推断
15356634 MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: 通过突变表型推断
9806545 MGI
acts upstream of or within branching involved in mammary gland duct morphogenesis IMP
IMP: 通过突变表型推断
19261859 MGI
acts upstream of or within cell fate commitment IMP
IMP: 通过突变表型推断
19261859 MGI
acts upstream of or within cellular response to interleukin-4 IDA
IDA: 通过直接分析推断
9798653 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: 通过表达模式推断
20439489 MGI
involved in circadian regulation of gene expression IDA
IDA: 通过直接分析推断
22274616 MGI
involved in endoplasmic reticulum calcium ion homeostasis IMP
IMP: 通过突变表型推断
21030605 MGI
involved in entrainment of circadian clock by photoperiod IDA
IDA: 通过直接分析推断
22274616 MGI
acts upstream of or within extrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
9806545 MGI
involved in fibroblast migration IMP
IMP: 通过突变表型推断
23555679 MGI
involved in innate immune response IDA
IDA: 通过直接分析推断
18248090 MGI
acts upstream of or within intrinsic apoptotic signaling pathway by p53 class mediator IMP
IMP: 通过突变表型推断
14992722 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: 通过突变表型推断
9806545 MGI
involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
IMP: 通过突变表型推断
15626733 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
IMP: 通过突变表型推断
21030605 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to oxidative stress IMP
IMP: 通过突变表型推断
21030605 MGI
acts upstream of or within myeloid cell differentiation IMP
IMP: 通过突变表型推断
9488655 MGI
acts upstream of or within negative regulation of angiogenesis IMP
IMP: 通过突变表型推断
16915281 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
9488655 MGI
involved in negative regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
24407287 MGI
involved in negative regulation of interleukin-1 production IMP
IMP: 通过突变表型推断
24407287 MGI
involved in oncogene-induced cell senescence IMP
IMP: 通过突变表型推断
10910364 MGI
acts upstream of or within positive regulation of apoptotic signaling pathway IGI
IGI: 通过遗传相互作用推断
10684855 MGI
acts upstream of or within positive regulation of apoptotic signaling pathway IMP
IMP: 通过突变表型推断
10684855 MGI
involved in positive regulation of fibroblast proliferation IMP
IMP: 通过突变表型推断
23555679 MGI
involved in positive regulation of peptidyl-lysine acetylation IMP
IMP: 通过突变表型推断
10910364 MGI
involved in positive regulation of signal transduction by p53 class mediator IMP
IMP: 通过突变表型推断
10910364 MGI
acts upstream of or within protein import into nucleus IMP
IMP: 通过突变表型推断
15356634 MGI
acts upstream of or within protein-containing complex localization IMP
IMP: 通过突变表型推断
15356634 MGI
involved in regulation of calcium ion transport into cytosol IMP
IMP: 通过突变表型推断
21030605 MGI
involved in regulation of cell adhesion IMP
IMP: 通过突变表型推断
23555679 MGI
involved in regulation of circadian rhythm IDA
IDA: 通过直接分析推断
22274616 MGI
acts upstream of or within response to UV IMP
IMP: 通过突变表型推断
15626733 MGI
acts upstream of or within response to gamma radiation IMP
IMP: 通过突变表型推断
9806545 MGI
acts upstream of or within response to hypoxia IMP
IMP: 通过突变表型推断
16915281 MGI
acts upstream of or within retinoic acid receptor signaling pathway IMP
IMP: 通过突变表型推断
9488655 MGI
involved in suppression of viral release by host IDA
IDA: 通过直接分析推断
18248090 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
15356634 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in PML body IDA
IDA: 通过直接分析推断
16461359 MGI
located in PML body IMP
IMP: 通过突变表型推断
10779416 MGI
located in cytosol IDA
IDA: 通过直接分析推断
21030605 MGI
located in nuclear matrix IDA
IDA: 通过直接分析推断
15252119 MGI
located in nucleus IDA
IDA: 通过直接分析推断
10716735 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein PML

probable transcription factor PML

Pml 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Pml Q8BSJ6 Nr2c1 Mus musculus Q505F1
Anti Bait CoIP
18682553
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N10633 LSTc 99.64% 否
HY-127130 Spicamycin / 否
HY-175354 PROTAC BET Degrader-13 Degrader / 否
HY-RS10765 PML Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-U00237B L-771688 hydrochloride Antagonist / 否
HY-118156 L-699333 / 否
HY-RS18592 Pml Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25077 Pml Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pml NCBI NCBI:5371
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