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  2. EEF1A1 - eukaryotic translation elongation factor 1 alpha 1 Gene

EEF1A1 - eukaryotic translation elongation factor 1 alpha 1 Gene

中文名称:真核翻译延伸因子 1 alpha 1

种属: Homo sapiens

同用名: CCS3; EF1A; PTI1; CCS-3; EE1A1; EEF-1; EEF1A; EF-Tu; EF1A1; LENG7; eEF1A-1; GRAF-1EF; EF1alpha1

基因 ID: 1915 | 基因类型: protein coding

关于 EEF1A1

Cytogenetic location: 6q13 Genomic coordinates (GRCh38): 6:73,515,750-73,521,032 (from NCBI)

This gene has 23 transcripts (splice variants), 236 orthologues and 18 paralogues. Ubiquitous expression in ovary (RPKM 2994.9), thyroid (RPKM 2551.7) and 25 other tissues.


该基因编码延伸因子 1 复合物的 alpha 亚基的亚型,负责将氨酰 tRNA 酶促递送至核糖体。这种亚型 (α 1) 在脑、胎盘、肺、肝、肾和胰腺中表达,另一种亚型 (α 2) 在脑、心脏和骨骼肌中表达。在 66% 的 Felty 综合征患者中,这种亚型被确定为自身抗原。已发现该基因在许多染色体上有多个拷贝,其中一些 (如果不是全部的话) 代表不同的假基因。[RefSeq 提供,2008 年 7 月]

This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq, Jul 2008]

EEF1A1 基因产物(1)

mRNA Protein Name
NM_001402.6 NP_001393.1 elongation factor 1-alpha 1

EEF1A1 蛋白结构


GTP_EFTU: Elongation factor Tu GTP binding domain (5 - 237)


GTP_EFTU_D2: Elongation factor Tu domain 2 (260 - 326)


GTP_EFTU_D3: Elongation factor Tu C-terminal domain (334 - 441)

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  • 462 a.a.
蛋白主名 其他名称

elongation factor 1-alpha 1

CTCL tumor antigen

重组 EEF1A1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72178 EEF1A1 Protein, Human (His-SUMO) P68104 (M1-K462) ≥95%


疾病名称 别名
Felty Syndrome

Felty'S Syndrome

Rheumatoid Arthritis With Splenoadenomegaly And Leukopenia

Familial Felty'S Syndrome

Rheumatoid Arthritis, Splenomegaly And Neutropenia

Splenomegaly-Neutropenia-Rheumatoid Arthritis Syndrome

Feltys Syndrome

Eukaryotic Translation Elongation Factor 1 Alpha-1-Like 14


Prostatic Carcinoma Tumor-Inducing Gene 1


Cervical Cancer

Cervical Cancer, Somatic

Neoplasm Of Uterine Cervix

Cervix Cancer

Uterine Cervical Neoplasm

Cervical Neoplasm

Cervix Uteri Cancer

Tumor Of The Cervix Uteri


Uterine Cervical Cancer

Neoplasms Cervical

Uterine Cervical Neoplasms

Cervical Cancers

Cancer, Cervical, Somatic

Malignant Tumor Of Cervix

Cervix Carcinoma

Fragile X Syndrome


Martin-Bell Syndrome

Fraxa Syndrome

Marker X Syndrome

X-Linked Mental Retardation And Macroorchidism

Fragile X Mental Retardation Syndrome

Fra Syndrome

Mental Retardation, X-Linked, Associated With Marxq28

X-Linked Intellectual Disability And Macroorchidism

Frax Syndrome

Symptomatic Form Of Fragile X Syndrome In Female Carriers

Fragile-X Syndrome

Fraxe Syndrome

Agenesis Of Corpus Callosum, Cardiac, Ocular, And Genital Syndrome


Legionnaire Disease

Legionnaires' Disease

Legionnaires Disease

Legionnaire Disease, Susceptibility To


Legionella Pneumonia

Infection By Legionella Pneumophilia

Legionnaire'S Disease


Legionaire Disease, Susceptibility To

Legionnaires Pneumonia

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma



Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer


Legionella Infection

Pontiac Fever

Legionnaires' Disease

Infection By Legionella Pneumophilia

Legionella Pneumophila Infection

Retinitis Pigmentosa


Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration


Retinitis Pigmentosa Autosomal Recessive


Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1

Bardet-Biedl Syndrome


Biedl-Bardet Syndrome

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease



Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease


Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma


种属 基因名 来源 基因 ID
Mus musculus EEF1A1 MGD MGI:1096881
Rattus norvegicus EEF1A1 RGD RGD:67387
Macaca mulatta EEF1A1 VGNC VGNC:81065
Bos taurus EEF1A1 VGNC VGNC:56362
Others EEF1A1 NCBI