2. Gene
  3. Kdm4b - lysine (K)-specific demethylase 4B Gene

Kdm4b - lysine (K)-specific demethylase 4B Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Jmjd2b; 4732474L06Rik

基因 ID: 193796 | 基因类型: protein coding

关于 Kdm4b

功能概要

Enables histone H3-methyl-lysine-9 demethylase activity. Acts upstream of or within histone H3-K36 demethylation; histone H3-K9 demethylation; and negative regulation of histone H3-K9 trimethylation. Located in pericentric heterochromatin. Is expressed in several structures, including early conceptus; genitourinary system; heart; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability; breast cancer; colorectal cancer; malignant peripheral nerve sheath tumor; and stomach Cancer. Orthologous to human KDM4B (lysine demethylase 4B). [provided by Alliance of Genome Resources, Apr 2022]

Kdm4b 基因产物(2)

mRNA Protein Name
NM_001357909.1 NP_001344838.1 lysine-specific demethylase 4B isoform 2
NM_172132.3 NP_742144.1 lysine-specific demethylase 4B isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables histone H3K36 demethylase activity IDA
IDA: 通过直接分析推断
16738407 MGI
enables histone H3K36 demethylase activity IMP
IMP: 通过突变表型推断
16738407 MGI
enables histone H3K9 demethylase activity IDA
IDA: 通过直接分析推断
16738407 MGI
enables histone H3K9 demethylase activity IMP
IMP: 通过突变表型推断
16738407 MGI
enables histone demethylase activity IDA
IDA: 通过直接分析推断
19144645 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in brain development IMP
IMP: 通过突变表型推断
27023172 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in pericentric heterochromatin IDA
IDA: 通过直接分析推断
16738407 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

lysine-specific demethylase 4B

[histone H3]-trimethyl-L-lysine(9) demethylase 4B

jmjC domain-containing histone demethylation protein 3B

jumonji domain-containing protein 2B

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-104048 QC6352 Inhibitor 99.13% 否
HY-12725 ML324 Inhibitor 98.35% 否
HY-101799 NCGC00244536 Inhibitor 99.70% 否
HY-110154 NSC636819 98.90% 否
HY-RS07214 KDM4B Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17132 Kdm4b Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23577 Kdm4b Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Kdm4b NCBI NCBI:23030
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