CELSR3 - cadherin EGF LAG seven-pass G-type receptor 3 Gene

中文名称：钙粘蛋白 EGF LAG 七通 G 型受体 3

种属: Homo sapiens

同用名: FMI1; EGFL1; HFMI1; MEGF2; ADGRC3; CDHF11; RESDA1

基因 ID: 1951 | 基因类型: protein coding

关于 CELSR3

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,636,463-48,662,886 (from NCBI)

This gene has 4 transcripts (splice variants), 206 orthologues and 6 paralogues. Broad expression in brain (RPKM 3.0), testis (RPKM 2.3) and 17 other tissues.

功能概要

该基因属于钙粘蛋白超家族中的火烈鸟亚科。火烈鸟钙粘蛋白由不与连环蛋白相互作用的非经典型钙粘蛋白组成。它们是质膜蛋白，在其胞外域中包含七个表皮生长因子样重复序列、九个钙粘蛋白结构域和两个层粘连蛋白 A G 型重复序列。它们还有七个跨膜结构域，这是它们亚家族的一个特征。编码的蛋白质可能参与接触依赖性神经突生长的调节，并可能在肿瘤形成中发挥作用。[RefSeq 提供，2013 年 6 月]

This gene belongs to the flamingo subfamily, which is included in the Cadherin superfamily. The flamingo Cadherins consist of nonclassic-type Cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine Cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]

CELSR3 基因产物(1)

mRNA	Protein	Name
NM_001407.3	NP_001398.2	cadherin EGF LAG seven-pass G-type receptor 3 precursor

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	17474147	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CELSR3 蛋白结构

Cadherin

EGF

Laminin_G_2

EGF

Laminin_G_2

Laminin_EGF

HRM

GPS

7tm_2

0
600
1200
1800
2400
3000
3312 a.a.

蛋白主名

其他名称

cadherin EGF LAG seven-pass G-type receptor 3

EGF-like protein 1

关联疾病

疾病名称

别名

Autosomal Dominant Wolfram Syndrome

Alzheimer Disease 15

AD15	Alzheimer'S Disease 15
Alzheimer Disease Without Neurofibrillary Tangles	Alzheimer'S Disease 15, Late Onset
Alzheimer'S Disease Without Neurofibrillary Tangles

Bjornstad Syndrome

BJS	Pili Torti And Nerve Deafness
Ptd	Pili Torti-Deafness Syndrome
Deafness-Pili Torti-Hypogonadism Syndrome	Deafness And Pili Torti, Bjornstad Type
Pili Torti-Sensorineural Hearing Loss	Björnstad Syndrome
Ptnd	Hearing Loss-Pili Torti-Hypogonadism Syndrome
Bjoernstad Syndrome

Bladder Exstrophy-Epispadias-Cloacal Exstrophy Complex

Exstrophy-Epispadias Complex	Bladder Exstrophy-Epispadias-Cloacal Extrophy Complex
Beec	Eec
Exstrophy Of The Bladder	Bladder Exstrophy
Bladder Exstrophy And Epispadias Complex

Chronic Tic Disorder

Chronic Motor Or Vocal Tic Disorder	Tic Disorders
Tic Disorder	Tic Disorder Nos
Tic Nos	Tic Spasm Nos

Polymicrogyria, Bilateral Frontoparietal

Bilateral Frontoparietal Polymicrogyria	BFPP
Cerebellar Ataxia With Neuronal Migration Defect

Tic Disorder

Tics	Behavioral Tic

Bladder Exstrophy

Exstrophy Of The Bladder

Classic Exstrophy Of The Bladder

Gilles De La Tourette Syndrome

Tourette Syndrome	Tourette Disorder
GTS	Ts
Gilles De La Tourette'S Syndrome	Motor-Verbal Tic Disorder
Guinon'S Disease	Psychogenic Tics
Tourette'S Syndrome	Chronic Motor And Vocal Tic Disorder
Td	Tourette'S Disease
Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]	Combined Vocal And Multiple Motor Tic Disorder
Tic De La Tourette

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Strabismus

Strabismus, Susceptibility To	Strabismus, Susceptibility To, 1
Strabismus 1

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-175232	GL64		/	否
HY-RS02467	CELSR3 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS18305	Celsr3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS24783	Celsr3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	CELSR3	MGD	MGI:1858236
Canis familiaris	CELSR3	VGNC	VGNC:54589
Bos taurus	CELSR3	VGNC	VGNC:27171
Macaca mulatta	CELSR3	VGNC	VGNC:71148
Rattus norvegicus	CELSR3	RGD	RGD:621787
Felis catus	CELSR3	VGNC	VGNC:82466
Others	CELSR3	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CELSR3 - cadherin EGF LAG seven-pass G-type receptor 3 Gene

关于 CELSR3

功能概要

CELSR3 基因产物(1)

CELSR3 蛋白结构

关联疾病

直系同源

热门区域

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CELSR3 - cadherin EGF LAG seven-pass G-type receptor 3 Gene

关于 CELSR3

功能概要

CELSR3 基因产物(1)

CELSR3 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z