2. Gene
  3. NLRC3 - NLR family CARD domain containing 3 Gene

NLRC3 - NLR family CARD domain containing 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 NLR 家族 CARD 结构域 3

种属: Homo sapiens

同用名: NOD3; CLR16.2

基因 ID: 197358 | 基因类型: protein coding

关于 NLRC3

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,539,033-3,577,403 (from NCBI)

This gene has 5 transcripts (splice variants), 194 orthologues and 20 paralogues. Broad expression in lymph node (RPKM 6.9), spleen (RPKM 4.9) and 23 other tissues.

功能概要

该基因编码一个 NOD 样受体家族成员。编码的蛋白质是先天免疫的细胞溶质调节剂。这种蛋白质直接与干扰素基因刺激物 (STING) 相互作用，以阻止其正常运输，从而破坏依赖于 STING 的先天免疫反应激活。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 2 月]

This gene encodes a NOD-like Receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

NLRC3 基因产物(1)

mRNA Protein Name
NM_178844.4 NP_849172.2 NLR family CARD domain-containing protein 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
24560620 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T cell activation IEP
IEP: 通过表达模式推断
15705585 GOA
involved in canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
15705585 GOA
involved in negative regulation of NF-kappaB transcription factor activity IDA
IDA: 通过直接分析推断
15705585 GOA
involved in negative regulation of NLRP3 inflammasome complex assembly IDA
IDA: 通过直接分析推断
25277106 GOA
acts upstream of or within negative regulation of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
22863753 GOA
involved in negative regulation of inflammatory response IDA
IDA: 通过直接分析推断
25277106 GOA
involved in negative regulation of interleukin-6 production IDA
IDA: 通过直接分析推断
22863753 GOA
involved in negative regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
22863753 GOA
involved in negative regulation of non-canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
25277106 GOA
involved in negative regulation of tumor necrosis factor production IDA
IDA: 通过直接分析推断
22863753 GOA
involved in negative regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
22863753 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
15705585 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
24560620 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NLRC3 蛋白结构

NACHT

NACHT: NACHT domain (139 - 304)

LRR_6

LRR_6: Leucine Rich repeat (667 - 687)

LRR_6

LRR_6: Leucine Rich repeat (693 - 715)

LRR_6

LRR_6: Leucine Rich repeat (721 - 743)

LRR_6

LRR_6: Leucine Rich repeat (776 - 799)

LRR_6

LRR_6: Leucine Rich repeat (805 - 825)

LRR_6

LRR_6: Leucine Rich repeat (832 - 854)

LRR_6

LRR_6: Leucine Rich repeat (888 - 910)

LRR_6

LRR_6: Leucine Rich repeat (944 - 967)

LRR_6

LRR_6: Leucine Rich repeat (1001 - 1022)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1036 a.a.
蛋白主名 其他名称

NLR family CARD domain-containing protein 3

CARD15-like protein

NLRC3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NLRC3 Q7RTR2 PYCARD Homo sapiens Q9ULZ3
Anti Bait CoIP
25277106
种属内
NLRC3 Q7RTR2 PYCARD Homo sapiens Q9ULZ3
Anti Tag CoIP
25277106
种属内
NLRC3 Q7RTR2 PYCARD Homo sapiens Q9ULZ3
Confocal
25277106
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cicatricial Entropion
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N0921 Dihydromethysticin 99.94% 否
HY-RS09346 NLRC3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20066 Nlrc3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26570 Nlrc3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris NLRC3 VGNC VGNC:43843
Macaca mulatta NLRC3 VGNC VGNC:75282
Felis catus NLRC3 VGNC VGNC:63826
Rattus norvegicus NLRC3 RGD RGD:1304902
Mus musculus NLRC3 MGD MGI:2444070
Bos taurus NLRC3 VGNC VGNC:32112
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