ELF1 - E74 like ETS transcription factor 1 Gene

中文名称：E74 样 ETS 转录因子 1

种属: Homo sapiens

同用名: RIA1; EFTUD1

基因 ID: 1997 | 基因类型: protein coding

关于 ELF1

Cytogenetic location: 13q14.11 Genomic coordinates (GRCh38): 13:40,931,919-41,061,386 (from NCBI)

This gene has 5 transcripts (splice variants), 194 orthologues and 28 paralogues. Ubiquitous expression in bone marrow (RPKM 46.7), lymph node (RPKM 34.5) and 25 other tissues.

功能概要

该基因编码一个 E26 转化特异性相关转录因子。编码的蛋白质主要在淋巴细胞中表达，并作为增强子和阻遏物来调节各种基因的转录。可变剪接导致多个转录本变体。[RefSeq 提供，2009 年 2 月]

This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and acts as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

ELF1 基因产物(6)

mRNA	Protein	Name
NM_001145353.1	NP_001138825.1	ETS-related transcription factor Elf-1 isoform b
NM_001370329.1	NP_001357258.1	ETS-related transcription factor Elf-1 isoform c
NM_001370330.1	NP_001357259.1	ETS-related transcription factor Elf-1 isoform a
NM_001370331.1	NP_001357260.1	ETS-related transcription factor Elf-1 isoform a
NM_001370332.1	NP_001357261.1	ETS-related transcription factor Elf-1 isoform a
NM_172373.4	NP_758961.1	ETS-related transcription factor Elf-1 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	8756667	GOA
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	14970218	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	8756667	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10207087	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	19674970	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	8756667	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	19674970	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ELF1 蛋白结构

Elf-1_N

Ets

0
100
200
300
400
500
619 a.a.

蛋白主名

其他名称

ETS-related transcription factor Elf-1

E74-like factor 1 (ets domain transcription factor)

ELF1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ELF1	P32519	NFYC	Homo sapiens	Q13952-2	Validated Y2H	32296183
种属内	ELF1	P32519	HOXC13	Homo sapiens	P31276	Pull Down	18692240
种属内	ELF1	P32519	HOXC13	Homo sapiens	P31276	Anti Tag CoIP	18692240
种属内	ELF1	P32519	SP1	Homo sapiens	P08047	Pull Down	10976766
种属内	ELF1	P32519	HSPBP1	Homo sapiens	Q9NZL4	Anti Tag CoIP	28514442

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Intramuscular Hemangioma

Intramuscular Angioma	Hemangioma Intramuscular
Hemangioma, Intramuscular

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04193	EFNA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS04298	ELF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS04320	ELOF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS17828	Efna2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS19817	Sptbn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS21333	Elf1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS27852	Elf1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	ELF1	VGNC	VGNC:28426
Felis catus	ELF1	VGNC	VGNC:61805
Canis familiaris	ELF1	VGNC	VGNC:40298
Rattus norvegicus	ELF1	RGD	RGD:620697
Macaca mulatta	ELF1	VGNC	VGNC:72205
Mus musculus	ELF1	MGD	MGI:107180

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ELF1 - E74 like ETS transcription factor 1 Gene

关于 ELF1

功能概要

ELF1 基因产物(6)

ELF1 蛋白结构

ELF1 蛋白互作信息

关联疾病

直系同源

热门区域

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ELF1 - E74 like ETS transcription factor 1 Gene

关于 ELF1

功能概要

ELF1 基因产物(6)

ELF1 蛋白结构

ELF1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z