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  2. ELK1 - ETS transcription factor ELK1 Gene

ELK1 - ETS transcription factor ELK1 Gene

中文名称:ETS 转录因子 ELK1

种属: Homo sapiens

基因 ID: 2002 | 基因类型: protein coding

关于 ELK1

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:47,635,520-47,650,604 (from NCBI)

This gene has 4 transcripts (splice variants), 179 orthologues and 28 paralogues. Ubiquitous expression in ovary (RPKM 19.1), brain (RPKM 15.9) and 25 other tissues.

功能概要

该基因是转录因子 Ets 家族和三元复合因子 (TCF) 亚家族的成员。 TCF 亚家族的蛋白质通过与 c-fos 原癌基因启动子中的血清反应因子和血清反应元件结合形成三元复合物。由该基因编码的蛋白质是 ras-raf-MAPK 信号级联的核目标。该基因通过使用替代翻译起始密码子和选择性剪接产生多种亚型。已在 7 号和 14 号染色体上鉴定出相关的假基因。[RefSeq 提供,2012 年 3 月]

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012]

ELK1 基因产物(3)

mRNA Protein Name
NM_001114123.3 NP_001107595.1 ETS domain-containing protein Elk-1 isoform a
NM_001257168.1 NP_001244097.1 ETS domain-containing protein Elk-1 isoform b
NM_005229.4 NP_005220.2 ETS domain-containing protein Elk-1 isoform a

ELK1 蛋白结构

Ets

Ets: Ets-domain (5 - 87)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 428 a.a.
蛋白主名 其他名称

ETS domain-containing protein Elk-1

ELK1, ETS transcription factor

重组 ELK1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74176 ELK1 Protein, Human (sf9, His-GST) P19419 (M1-P428) ≥95%

关联疾病

疾病名称 别名
Prion Disease

Spongiform Encephalopathy

Transmissible Spongiform Encephalopathies

Prion Diseases

Prion Disease Pathway

Transmissible Spongiform Encephalopathy

Prion Induced Disorder

Prion Protein Disease

Inherited Human Transmissible Spongiform Encephalopathies

Prion Protein Diseases

Prion-Associated Disorders

Prion-Induced Disorders

Transmissible Dementias

Tses

Human Prion Disease

Tse

Encephalopathy, Transmissible Spongiform

Prion Disease, Susceptibility To

Spongiform Encephalopathies

Human Transmissible Spongiform Encephalopathies, Inherited

Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus ELK1 MGD MGI:101833
Canis familiaris ELK1 VGNC VGNC:40303
Felis catus ELK1 VGNC VGNC:61810
Rattus norvegicus ELK1 RGD RGD:1598663
Bos taurus ELK1 VGNC VGNC:28432
Others ELK1 NCBI