2. Gene
  3. GKN2 - gastrokine 2 Gene

GKN2 - gastrokine 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：胃泌素 2

种属: Homo sapiens

同用名: GDDR; TFIZ1; PRO813; BRICD1B; VLTI465

基因 ID: 200504 | 基因类型: protein coding

关于 GKN2

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:68,945,232-68,952,893 (from NCBI)

This gene has 2 transcripts (splice variants), 126 orthologues and 2 paralogues. Restricted expression toward stomach (RPKM 1463.9).

功能概要

由该基因编码的分泌蛋白在胃表面粘液细胞中产生，它可以结合三叶因子家族肽 1 或 gastrokine-1。该基因可能是抑癌基因，因为它在胃癌组织中的表达显着降低。编码的蛋白质与 gastrokine-1 相互作用并调节胃粘膜的稳态。[RefSeq 提供，2015 年 12 月]

The secretory protein encoded by this gene is produced in gastric surface mucous cells, where it can bind trefoil factor family peptide 1 or gastrokine-1. This gene may be a tumor suppressor gene, as its expression is markedly decreased in gastric Cancer tissues. The encoded protein interacts with gastrokine-1 and regulates homeostasis of the gastric mucosa. [provided by RefSeq, Dec 2015]

GKN2 基因产物(1)

mRNA Protein Name
NM_182536.3 NP_872342.2 gastrokine-2 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GKN2 蛋白结构

BRICHOS

BRICHOS: BRICHOS domain (55 - 150)

  • 0
  • 100
  • 184 a.a.
蛋白主名 其他名称

gastrokine-2

BRICHOS domain containing 1B

GKN2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GKN2 Q86XP6 TMEM237 Homo sapiens Q96Q45-2
Validated Y2H
32296183
种属内
GKN2 Q86XP6 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
种属内
GKN2 Q86XP6 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
种属内
GKN2 Q86XP6 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
种属内
GKN2 Q86XP6 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05462 GKN2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris GKN2 VGNC VGNC:41247
Bos taurus GKN2 VGNC VGNC:29389
Mus musculus GKN2 MGD MGI:1913534
Macaca mulatta GKN2 VGNC VGNC:72995
Rattus norvegicus GKN2 RGD RGD:1311934
Felis catus GKN2 VGNC VGNC:62571
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