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  3. Ryr2 - ryanodine receptor 2, cardiac Gene

Ryr2 - ryanodine receptor 2, cardiac Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: RYR-2; 9330127I20Rik

基因 ID: 20191 | 基因类型: protein coding

关于 Ryr2

功能概要

Enables several functions, including Calmodulin binding activity; identical protein binding activity; and ryanodine-sensitive calcium-release channel activity. Involved in several processes, including cellular response to organonitrogen compound; regulation of heart contraction; and release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Acts upstream of or within several processes, including calcium ion transport; left ventricular cardiac muscle tissue morphogenesis; and response to caffeine. Located in Z disc; sarcoplasmic reticulum membrane; and smooth endoplasmic reticulum. Part of Calcium Channel complex. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Used to study arrhythmogenic right ventricular dysplasia 2; catecholaminergic polymorphic ventricular tachycardia 1; and heart disease. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy; arrhythmogenic right ventricular dysplasia 2; and catecholaminergic polymorphic ventricular tachycardia 1. Orthologous to human RYR2 (ryanodine receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ryr2 基因产物(1)

mRNA Protein Name
NM_023868.2 NP_076357.2 ryanodine receptor 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium channel activity IDA
IDA: 通过直接分析推断
9628868 MGI
enables calmodulin binding IDA
IDA: 通过直接分析推断
17431507 MGI
enables enzyme binding IPI
IPI: 通过物理相互作用推断
16213210 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
12324472 MGI
enables intracellularly gated calcium channel activity IDA
IDA: 通过直接分析推断
10473538 MGI
enables organic cyclic compound binding IPI
IPI: 通过物理相互作用推断
17431507 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16352659 MGI
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
12676814 MGI
enables ryanodine-sensitive calcium-release channel activity IDA
IDA: 通过直接分析推断
14593104 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Purkinje myocyte to ventricular cardiac muscle cell signaling IMP
IMP: 通过突变表型推断
17872467 MGI
acts upstream of or within calcium ion transmembrane import into cytosol IMP
IMP: 通过突变表型推断
17431507 MGI
acts upstream of or within calcium ion transmembrane transport IMP
IMP: 通过突变表型推断
21673970 MGI
acts upstream of or within calcium ion transport IDA
IDA: 通过直接分析推断
14593104 MGI
involved in calcium ion transport IDA
IDA: 通过直接分析推断
10473538 MGI
involved in calcium ion transport IMP
IMP: 通过突变表型推断
9628868 MGI
acts upstream of or within calcium ion transport IPI
IPI: 通过物理相互作用推断
16204356 MGI
involved in calcium-mediated signaling IMP
IMP: 通过突变表型推断
9628868 MGI
acts upstream of or within cardiac muscle hypertrophy IMP
IMP: 通过突变表型推断
17431507 MGI
acts upstream of or within cellular response to caffeine IDA
IDA: 通过直接分析推断
12089338 MGI
involved in cellular response to caffeine IDA
IDA: 通过直接分析推断
9628868 MGI
involved in cellular response to epinephrine stimulus IMP
IMP: 通过突变表型推断
17872467 MGI
involved in embryonic heart tube morphogenesis IMP
IMP: 通过突变表型推断
9628868 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: 通过突变表型推断
12089338 MGI
involved in intracellular calcium ion homeostasis IMP
IMP: 通过突变表型推断
9628868 MGI
acts upstream of or within left ventricular cardiac muscle tissue morphogenesis IMP
IMP: 通过突变表型推断
17431507 MGI
acts upstream of or within positive regulation of heart rate IMP
IMP: 通过突变表型推断
12089338 MGI
involved in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IGI
IGI: 通过遗传相互作用推断
12837242 MGI
involved in regulation of heart rate IMP
IMP: 通过突变表型推断
17872467 MGI
involved in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA
IDA: 通过直接分析推断
20226167 MGI
acts upstream of or within release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IMP
IMP: 通过突变表型推断
12089338 MGI
acts upstream of or within response to caffeine IDA
IDA: 通过直接分析推断
14593104 MGI
involved in response to caffeine IDA
IDA: 通过直接分析推断
10473538 MGI
involved in response to hypoxia IDA
IDA: 通过直接分析推断
19120137 MGI
involved in type B pancreatic cell apoptotic process IMP
IMP: 通过突变表型推断
15044459 MGI
involved in ventricular cardiac muscle cell action potential IMP
IMP: 通过突变表型推断
17872467 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Z disc IDA
IDA: 通过直接分析推断
16204356 MGI
part of calcium channel complex IDA
IDA: 通过直接分析推断
16213210 MGI
located in membrane IDA
IDA: 通过直接分析推断
17431507 MGI
located in sarcomere IDA
IDA: 通过直接分析推断
20226167 MGI
located in sarcoplasmic reticulum IDA
IDA: 通过直接分析推断
12919952 MGI
located in sarcoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
14592808 MGI
located in smooth endoplasmic reticulum IDA
IDA: 通过直接分析推断
23454728 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ryanodine receptor 2

calcium release channel

cardiac muscle ryanodine receptor

cardiac muscle ryanodine receptor-calcium release channel

ryanodine receptor type 2

type 2 ryanodine receptor

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-W010950 Flecainide Inhibitor 99.98% 否
HY-W010950A Flecainide hydrochloride Inhibitor 99.93% 否
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-119850 Aladorian Inhibitor 99.55% Phase 2
Pre-clinical Phase
生物活性分子 (16)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-149662 TMDJ-035 Inhibitor 99.92% 否
HY-15292 S107 Ligand 99.77% 否
HY-N7491A Ent-(+)-Verticilide Inhibitor 99.91% 否
HY-P5114A Maurocalcine TFA Agonist 95.19% 否
HY-RS12369 RYR2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-103059 SOICR-IN-1 99.62% 否
HY-P5114 Maurocalcine Agonist / 否
HY-Z7733 O-Desmethylcarvedilol Inhibitor 97.4% 否
HY-119850A Aladorian sodium Inhibitor / 否
HY-178344 Multi-target kinase-IN-6 / 否
HY-P5319 MCaE12A / 否
HY-149779 RyR2 stabilizer-1 Modulator / 否
HY-166478S O-Desmethyl carvedilol-d5 Inhibitor / 否
HY-RS19951 Ryr2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26453 Ryr2 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-W010950S Flecainide-d3 / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ryr2 NCBI NCBI:6262
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