2. Others Neuronal Signaling Membrane Transporter/Ion Channel
  3. Calcium Channel Isotope-Labeled Compounds
  4. O-Desmethyl carvedilol-d5

O-Desmethyl carvedilol-d5  (Synonyms: Desmethylcarvedilol-d5; BM-14242-d5)

目录号: HY-166478S
产品使用指南 技术支持

O-Desmethyl carvedilol-d5 (Desmethylcarvedilol-d5) 是氘代标记的 O-Desmethylcarvedilol. O-Desmethylcarvedilol (Desmethylcarvedilol) 是非选择性 β-肾上腺素受体 (β-AR) 拮抗剂 Carvedilol (HY-B0006) 的活性代谢物。O-Desmethylcarvedilol 可抑制表达瑞安诺丁受体 2 (RyR2) R4496C (RyR2R4496C) 突变的 HEK293 细胞中储存超载诱导的钙释放 (IC50 = 7.62 μM)。 O-Desmethylcarvedilol 可减缓清醒兔子的心率增加并防止 Isoproterenol（HY-B0468）引起的舒张压下降（ED50s = 32 和 5 μg/kg）。

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O-Desmethyl carvedilol-d<sub>5</sub> Chemical Structure

O-Desmethyl carvedilol-d5 Chemical Structure

CAS No. : 1794817-24-5

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Other Forms of O-Desmethyl carvedilol-d5:

O-Desmethyl carvedilol-d5 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

O-Desmethyl carvedilol-d5 (Desmethylcarvedilol-d5) is deuterium labeled O-Desmethylcarvedilol. O-Desmethylcarvedilol (Desmethylcarvedilol) is an active metabolite of the non-selective β-adrenergic receptor (β-AR) antagonist Carvedilol (HY-B0006). O-Desmethylcarvedilol inhibits store-overload-induced calcium release in HEK293 cells expressing the ryanodine receptor 2 (RyR2) R4496C (RyR2R4496C) mutation (IC50 = 7.62 μM). O-Desmethylcarvedilol reduces increases in heart rate and prevents decreases in diastolic blood pressure induced by Isoproterenol (HY-B0468) in conscious rabbits (ED50s = 32 and 5 μg/kg, respectively)[1][2].

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

O-Desmethyl carvedilol-d5 相关抗体:
分子量

397.48

Formula

C23H19D5N2O4
CAS 号
非标记 CAS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

O-Desmethyl carvedilol-d5 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

O-Desmethyl carvedilol-d51794817-24-5Desmethylcarvedilol-d5 BM-14242-d5Calcium ChannelIsotope-Labeled CompoundsCa2+ channelsCa channelsInhibitorinhibitorinhibit

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