2. Gene
  3. SLC29A1 - solute carrier family 29 member 1 (Augustine blood group) Gene

SLC29A1 - solute carrier family 29 member 1 (Augustine blood group) Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 29 成员 1 (奥古斯丁血型)

种属: Homo sapiens

同用名: ENT1

基因 ID: 2030 | 基因类型: protein coding

关于 SLC29A1

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:44,219,615-44,234,142 (from NCBI)

This gene has 24 transcripts (splice variants), 290 orthologues and 3 paralogues. Ubiquitous expression in adrenal (RPKM 38.0), fat (RPKM 34.4) and 25 other tissues.

功能概要

该基因是平衡核苷转运蛋白家族的成员。该基因编码一种跨膜糖蛋白，定位于质膜和线粒体膜，并介导细胞从周围介质中摄取核苷。该蛋白质被归类为对硝基苄基硫肌苷 (NBMPR) 的抑制敏感的平衡 (相对于浓缩) 转运蛋白。核苷转运体是缺乏从头核苷合成途径的细胞中核苷酸合成所必需的，也是摄取用于癌症和病毒化学疗法的细胞毒性核苷所必需的。已发现该基因的多个选择性剪接变体，编码相同的蛋白质。[RefSeq 提供，2008 年 7 月]

This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a Transmembrane Glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside Transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for Cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

SLC29A1 基因产物(6)

mRNA Protein Name
NM_001078175.3 NP_001071643.1 equilibrative nucleoside transporter 1 isoform 1
NM_001078177.2 NP_001071645.1 equilibrative nucleoside transporter 1 isoform 1
NM_001304462.2 NP_001291391.1 equilibrative nucleoside transporter 1 isoform 5
NM_001304465.2 NP_001291394.1 equilibrative nucleoside transporter 1 isoform 3
NM_001304466.2 NP_001291395.1 equilibrative nucleoside transporter 1 isoform 4
NM_001372327.1 NP_001359256.1 equilibrative nucleoside transporter 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables adenine transmembrane transporter activity IDA
IDA: 通过直接分析推断
21795683 GOA
enables cytidine transmembrane transporter activity IDA
IDA: 通过直接分析推断
10722669 GOA
enables guanine transmembrane transporter activity IDA
IDA: 通过直接分析推断
21795683 GOA
enables neurotransmitter transmembrane transporter activity IDA
IDA: 通过直接分析推断
9396714 GOA
enables nucleoside transmembrane transporter activity IDA
IDA: 通过直接分析推断
10722669 GOA
enables purine nucleoside transmembrane transporter activity IDA
IDA: 通过直接分析推断
9396714 GOA
enables pyrimidine- and adenosine-specific:sodium symporter activity IDA
IDA: 通过直接分析推断
21795683 GOA
enables uracil transmembrane transporter activity IDA
IDA: 通过直接分析推断
21795683 GOA
enables uridine transmembrane transporter activity IDA
IDA: 通过直接分析推断
8986748 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenine transport IDA
IDA: 通过直接分析推断
21795683 GOA
involved in adenosine transport IDA
IDA: 通过直接分析推断
8986748 GOA
involved in cytidine transport IDA
IDA: 通过直接分析推断
10722669 GOA
involved in guanine transmembrane transport IDA
IDA: 通过直接分析推断
21795683 GOA
involved in hypoxanthine transport IDA
IDA: 通过直接分析推断
21795683 GOA
involved in inosine transport IDA
IDA: 通过直接分析推断
10722669 GOA
involved in neurotransmitter transport IDA
IDA: 通过直接分析推断
9396714 GOA
involved in nucleobase transport IDA
IDA: 通过直接分析推断
21795683 GOA
involved in nucleoside transmembrane transport IDA
IDA: 通过直接分析推断
8986748 GOA
involved in nucleoside transmembrane transport IMP
IMP: 通过突变表型推断
9396714 GOA
involved in nucleoside transport IDA
IDA: 通过直接分析推断
8986748 GOA
involved in purine nucleobase transmembrane transport IDA
IDA: 通过直接分析推断
21795683 GOA
involved in purine nucleoside transmembrane transport IDA
IDA: 通过直接分析推断
9396714 GOA
involved in pyrimidine nucleobase transmembrane transport IDA
IDA: 通过直接分析推断
21795683 GOA
involved in pyrimidine-containing compound transmembrane transport IMP
IMP: 通过突变表型推断
9396714 GOA
involved in thymine transport IDA
IDA: 通过直接分析推断
21795683 GOA
involved in uracil transmembrane transport IDA
IDA: 通过直接分析推断
21795683 GOA
involved in uridine transmembrane transport IDA
IDA: 通过直接分析推断
8986748 GOA
involved in uridine transmembrane transport IMP
IMP: 通过突变表型推断
9396714 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
12527552 GOA
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
12527552 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
23137377 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC29A1 蛋白结构

Nucleoside_tran

Nucleoside_tran: Nucleoside transporter (144 - 454)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 456 a.a.
蛋白主名 其他名称

equilibrative nucleoside transporter 1

equilibrative nitrobenzylmercaptopurine riboside (NBMPR)-sensitive nucleoside transporter

SLC29A1 抗体

目录号 产品名 应用 反应物种
HY-P81506 ENT1 Antibody (YA1251) IHC-P Human

关联疾病

疾病名称 别名
Fetal Erythroblastosis

Erythroblastosis, Fetal

Ef - Erythroblastosis Foetalis

Erythroblastosis Fetalis

Haemolytic Disease Due To Rhesus Isoimmunisation

Rhesus Isoimmunisation Of The Newborn
Gestational Diabetes

Gestational Diabetes Mellitus

GDM

Diabetes Mellitus Arising In Pregnancy

Maternal Gestational Diabetes Mellitus

Diabetes Mellitus, Gestational

Diabetes Mellitus, Pregnancy Related

Diabetes, Pregnancy-Induced

Diabetes Gestational

Diabetes, Gestational

Diabetes Of Pregnancy

Gdm - [Gestational Diabetes Mellitus]

Gestational Diabetes Mellitus Nos

Gestational Diabetes Complicating Pregnancy, Childbirth, Or The Puerperium
Diffuse Idiopathic Skeletal Hyperostosis

Hyperostosis, Diffuse Idiopathic Skeletal

Ankylosing Vertebral Hyperostosis

Dish

Disseminated Idiopathic Skeletal Hyperostosis

Forestier Disease

Forestier'S Disease

Hyperostosis Diffuse Idiopathic Skeletal
Vulvar Leiomyosarcoma
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Lung Pleomorphic Carcinoma
Splenic Tuberculosis

Tuberculosis, Splenic
Vulvar Leiomyoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-116927 KW-7158 Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13153 SLC29A1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22039 Slc29a1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus SLC29A1 VGNC VGNC:54237
Rattus norvegicus SLC29A1 RGD RGD:61899
Mus musculus SLC29A1 MGD MGI:1927073
Others SLC29A1 NCBI
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