2. Gene
  3. Sema4a - sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A Gene

Sema4a - sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: SemB; Semab

基因 ID: 20351 | 基因类型: protein coding

关于 Sema4a

功能概要

Predicted to enable chemorepellent activity and semaphorin receptor binding activity. Involved in several processes, including T-helper 1 cell differentiation; negative regulation of angiogenesis; and positive regulation of synapse assembly. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular space. Predicted to be integral component of plasma membrane. Is expressed in several structures, including blood vessel; central nervous system; primitive ventricle; retina; and ureteric trunk. Human ortholog(s) of this gene implicated in cone-rod dystrophy 10 and retinitis pigmentosa 35. Orthologous to human SEMA4A (semaphorin 4A). [provided by Alliance of Genome Resources, Apr 2022]

Sema4a 基因产物(4)

mRNA Protein Name
NM_001163489.1 NP_001156961.1 semaphorin-4A precursor
NM_001163490.1 NP_001156962.1 semaphorin-4A precursor
NM_001163491.1 NP_001156963.1 semaphorin-4A precursor
NM_013658.3 NP_038686.3 semaphorin-4A precursor
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T cell differentiation involved in immune response IMP
IMP: 通过突变表型推断
15780988 MGI
involved in T-helper 1 cell differentiation IMP
IMP: 通过突变表型推断
15780988 MGI
involved in axonogenesis IMP
IMP: 通过突变表型推断
20043131 MGI
involved in negative regulation of angiogenesis IMP
IMP: 通过突变表型推断
17318185 MGI
involved in positive regulation of excitatory synapse assembly IMP
IMP: 通过突变表型推断
29981480 MGI
involved in positive regulation of inhibitory synapse assembly IMP
IMP: 通过突变表型推断
29981480 MGI
involved in regulation of cell shape IDA
IDA: 通过直接分析推断
20043131 MGI
involved in regulation of endothelial cell migration IMP
IMP: 通过突变表型推断
17318185 MGI
involved in semaphorin-plexin signaling pathway IDA
IDA: 通过直接分析推断
20043131 MGI
involved in semaphorin-plexin signaling pathway IMP
IMP: 通过突变表型推断
17318185 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

semaphorin-4A

sema B

semaphorin-B

重组 Sema4a 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71283 Semaphorin-4A/SEMA4A Protein, Mouse (HEK293, His) Q62178 (T33-H682) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12657 SEMA4A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18312 Sema4a Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24790 Sema4a Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sema4a NCBI NCBI:64218
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