EPHA8 - EPH receptor A8 Gene

中文名称：EPH 受体 A8

种属: Homo sapiens

同用名: EEK; EK3; HEK3

关于 EPHA8

功能概要

该基因编码蛋白-酪氨酸激酶家族肝配蛋白受体亚家族的成员。 EPH 和 EPH 相关受体与介导发育事件有关，特别是在神经系统中。 EPH 亚家族中的受体通常具有单个激酶结构域和一个含有富含半胱氨酸结构域和 2 个纤连蛋白 III 型重复序列的胞外区域。基于肝配蛋白受体胞外结构域序列的相似性及其结合肝配蛋白-A 和肝配蛋白-B 配体的亲和力，肝配蛋白受体分为 2 组。由该基因编码的蛋白质作为肝配蛋白 A2、A3 和 A5 的受体发挥作用，并在哺乳动物神经系统发育过程中在短程接触介导的轴突导向中发挥作用。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the Ephrin Receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for Ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq, Jul 2008]