EphA8 蛋白, Human (HEK293, His)

The EPHA8 protein is a receptor tyrosine kinase that promiscuously binds to the GPI-anchored ephrin-A ligand to initiate bidirectional signaling. It participates in forward and reverse signaling pathways and is phosphorylated by ligands such as EFNA2, EFNA3, and EFNA5. EphA8 Protein, Human (HEK293, His) is the recombinant human-derived EphA8 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of EphA8 Protein, Human (HEK293, His) is 512 a.a., with molecular weight of 65-80 kDa.

EphA8 蛋白是一种受体酪氨酸激酶，与邻近细胞上 GPI 锚定的肝配蛋白 A 家族配体混杂结合，启动接触依赖性双向信号传导。源自受体的下游途径称为正向信号传导，而肝配蛋白配体下游的途径称为反向信号传导。GPI 锚定的肝配蛋白-A 配体（包括 EFNA2、EFNA3 和 EFNA5）表现出通过磷酸化激活 EPHA8 的能力。EPHA8 与 EFNA5 结合，可以调节整合素介导的细胞在纤连蛋白基质上的粘附和迁移，以及神经突的生长。在神经系统的发育中，EPHA8在轴突引导中也发挥着至关重要的作用。EPHA8 信号通路的下游效应器包括 FYN（在 EPHA8 激活后促进细胞粘附）和 MAP 激酶（有助于刺激神经突生长）。

Human

HEK293

C-6*His

P29322 (E31-T542)

2046  [NCBI]

EVNLLDTSTIHGDWGWLTYPAHGWDSINEVDESFQPIHTYQVCNVMSPNQNNWLRTSWVPRDGARRVYAEIKFTLRDCNSMPGVLGTCKETFNLYYLESDRDLGASTQESQFLKIDTIAADESFTGADLGVRRLKLNTEVRSVGPLSKRGFYLAFQDIGACLAILSLRIYYKKCPAMVRNLAAFSEAVTGADSSSLVEVRGQCVRHSEERDTPKMYCSAEGEWLVPIGKCVCSAGYEERRDACVACELGFYKSAPGDQLCARCPPHSHSAAPAAQACHCDLSYYRAALDPPSSACTRPPSAPVNLISSVNGTSVTLEWAPPLDPGGRSDITYNAVCRRCPWALSRCEACGSGTRFVPQQTSLVQASLLVANLLAHMNYSFWIEAVNGVSDLSPEPRRAAVVNITTNQAAPSQVVVIRQERAGQTSVSLLWQEPEQPNGIILEYEIKYYEKDKEMQSYSTLKAVTTRATVSGLKPGTRYVFQVRARTSAGCGRFSQAMEVETGKPRPRYDTRT

65-80 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.